Amyotrophic Lateral Sclerosis as Declining Recovery Capacity

Abstract

What if ALS progression is driven by a collapse in network recovery kinetics rather than a binary cellular trigger? This paper applies the Terrain–Timing Model to motor-neuron degeneration, operationalizing ALS as a progressive, non-linear collapse in the capacity of vulnerable motor networks to recover from repeated biological workloads.By mapping the Glutamate-Calcium-Energy Relay, it charts how the attenuation of astrocytic transporters triggers temporal handoff failures and compounding terrain carryover. Crucially, it resolves long-standing causality dilemmas by treating slow-wave sleep fragmentation and declining recovery kinetics as measurable, independent trajectory accelerators.