Author
Chou Cosmo
Recent research
- BiologyOpen access
Decoding non-coding genomic regulation across extended chromosomal distances (\ge 1 Mb) represents one of the foremost grand challenges in modern molecular genetics. While recent deep sequence foundation models (e.g., Google DeepMind's AlphaGenome) extend context windows to 10^6...
- Engineering & TechnologyOpen access
The Ranque-Hilsch Vortex Tube (RHVT)---frequently characterized as a mechanical "Maxwell's Demon"---represents one of the most persistent enigmas in non-equilibrium thermodynamics and fluid dynamics. Injected tangentially with a single stream of uniform compressed gas (T_{in} = 3...
- Physics & SpaceOpen access
The gravitational singularity constitutes the most profound mathematical breakdown of Einstein's General Relativity, appearing unavoidably at the center of black holes and the initial instant of the Big Bang as spatial coordinates shrink to zero (r \to 0), driving energy density,...
- Physics & SpaceOpen access
The persistent 5\sigma statistical discrepancy between early-universe Planck Cosmic Microwave Background (CMB) measurements (H_0 = 67.4 \pm 0.5 km/s/Mpc at z \approx 1100) and late-time local distance ladder observations from Cepheids and Type Ia Supernovae (H_0 = 73.04 \pm 1.04...
- Physics & SpaceOpen access
The 2024 astronomical discovery of "The Big Ring"---an ultra-large celestial structure spanning approximately 1.30 billion light-years (400 Mpc) in diameter with a circumference of 4.0 billion light-years at redshift z \approx 0.827---presents a catastrophic challenge to the foun...
- BiologyOpen access
Decoding non-coding genomic regulation across extended chromosomal distances (\ge 1 Mb) represents one of the foremost grand challenges in modern molecular genetics. While recent deep sequence foundation models (e.g., Google DeepMind's AlphaGenome) extend context windows to 10^6...
- Physics & SpaceOpen access
The overwhelming predominance of matter over antimatter in the observable universe---quantified by the baryon-to-photon ratio eta_B = (n_B - n_{\bar{B}}) / n_gamma = (6.104 +- 0.058) * 10^-10---remains one of the most profound unresolved puzzles in cosmology. Standard Model elect...
- Materials & EnergyOpen access
The Cosmological Constant Problem---widely recognized as the most catastrophic theoretical failure in modern physics---presents an unbridgeable 10^{120} order-of-magnitude discrepancy between the quantum field theoretic zero-point vacuum energy density and the cosmologically obse...
- Physics & SpaceOpen access
The 2024 astronomical discovery of "The Big Ring"---an ultra-large celestial structure spanning approximately 1.30 billion light-years (400 Mpc) in diameter with a circumference of 4.0 billion light-years at redshift z \approx 0.827---presents a catastrophic challenge to the foun...
- Materials & EnergyOpen access
The Cosmological Constant Problem---widely recognized as the most catastrophic theoretical failure in modern physics---presents an unbridgeable 10^{120} order-of-magnitude discrepancy between the quantum field theoretic zero-point vacuum energy density and the cosmologically obse...
- Physics & SpaceOpen access
The overwhelming predominance of matter over antimatter in the observable universe---quantified by the baryon-to-photon ratio eta_B = (n_B - n_{\bar{B}}) / n_gamma = (6.104 +- 0.058) * 10^-10---remains one of the most profound unresolved puzzles in cosmology. Standard Model elect...
- Materials & EnergyOpen access
Experimental breakthroughs in flexoelectricity and flexotronics (2025) have conclusively demonstrated that inhomogeneous geometric curvature and strain gradients (\nabla \boldsymbol{\epsilon}) induce macroscopic electric polarization (P_i = \mu_{ijkl} \partial \epsilon_{jk}/\part...
- AI & ComputingOpen access
The Collatz 3x+1 Conjecture, proposed by Lothar Collatz in 1937, is one of the most notoriously intractable problems in discrete dynamical systems and number theory. It asserts that for every positive integer n \in N^+, iterating the piecewise transformation T(n) = n/2 (if n is e...
- AI & ComputingOpen access
The folding of polypeptide chains into biologically active tertiary structures and the Collatz (3n+1) conjecture represent two notoriously difficult open problems characterized by extreme initial trajectory chaos collapsing into inevitable, deterministic attractors. In macromolec...
- AI & ComputingOpen access
The folding of polypeptide chains into biologically active tertiary structures and the Collatz (3n+1) conjecture represent two notoriously difficult open problems characterized by extreme initial trajectory chaos collapsing into inevitable, deterministic attractors. In macromolec...
- AI & ComputingOpen access
Quantum entanglement has challenged foundational physics since Albert Einstein famously characterized it as "spooky action at a distance." The apparent instantaneous collapse of spatial wavefunctions across spacelike intervals implies an unbridgeable rift between quantum non-loca...
- Physics & SpaceOpen access
The Birch and Swinnerton-Dyer (BSD) Conjecture, formulated in the 1960s, is a central Millennium Prize problem in arithmetic geometry and number theory. It connects the algebraic rank of rational points r = rank(E(Q)) on an elliptic curve E/Q with the analytic order of vanishing...
- Materials & EnergyOpen access
High-dimensional non-convex optimization is notoriously bottlenecked by the ubiquity of degenerate saddle points and glassy energy plateaus, where standard gradient descent, momentum methods, and stochastic Langevin dynamics suffer polynomial or exponential deceleration O(1/\epsi...
- AI & ComputingOpen access
The Poincaré Conjecture, formulated by Henri Poincaré in 1904, stands as one of the defining triumphs of modern topology, asserting that every simply-connected, closed 3-manifold is homeomorphic to the 3-sphere S^3. Following Richard S. Hamilton's formulation of the Ricci flow (1...
- AI & ComputingOpen access
In late August 2026, mathematical physics experienced a historic paradigm shift: the Lean 4 formalization of Fermat's Last Theorem (13 million lines of code, Peng et al.) and the resolution of the 78-year-old Hopf problem on the existence of an integrable complex structure on the...