Research works

Transcriptomic profiling of tropomyosin isoforms in bladder cancer: multi-platform sequencing and experimental validation

mRNA isoform level-based biomarkers are understudied but might complement DNA based approaches. The expression of tropomyosin isoforms differs between normal and cancer cells. Tropomyosin (TPM) isoforms generated by alternative splicing may contribute to Bladder Cancer (BC) biolo...

Deployment of edge-lightweight AI vertical models in multimodal anomaly detection and energy optimization of tech-long production line

Aiming at the problems that the abnormal state of high-speed liquid packaging production lines is difficult to identify in time, the computing power of edge controller is limited, and the energy consumption regulation and condition monitoring are separated from each other, a mult...

Learning shared hyperelastic constitutive representation from heterogeneous full-field experiments across multiple materials

A material-conditioned Physics-Augmented Neural Network is introduced for unsupervised multimaterial hyperelastic constitutive learning from experimental full-field data. The complete database comprises 30 experiments quantified by image correlation on various materials such as e...

Research on the retorting pyrolysis mechanism and rational control conditions in underground coal gasification

Using coal samples from the Hancheng Magouqu Mine, thermogravimetric and fixed-bed experiments were conducted to analyze the evolution of pyrolysis products . Finally, rational control conditions were proposed based on different gasification processes.

Chemogenetic inhibition of the ventrolateral orbitofrontal cortex disrupts novelty-guided updating of spatial memories and alters hippocampal engram reactivation

Abstract Rationale Adaptive behavior requires revising memories when outcomes deviate from expectations. The orbitofrontal cortex (OFC) is implicated in representing outcome expectancies, but its role in memory-updating, beyond value-based learning, remains unclear. Objectives We...

Self-report measures of mindfulness for children: convergent validity, predictive validity, and impacts of social desirability bias

Mindfulness-based interventions have shown promise in supporting psychological well-being in children. However, mindfulness is commonly measured using self-report questionnaires, a method that might be problematic due to its reliance on children’s accurate self-perceptions of the...

Climate change exacerbates residential radon exposure and lung cancer risk

Abstract Climate change adaptation strategies, such as increased air conditioning use, greater time spent indoors, and seeking cooler lower-floor spaces, may inadvertently increase residential radon exposure and associated lung cancer risk. We conducted a scoping review of litera...

Start-up and inertialess instability of elasto-viscoplastic channel flow

An exploration is presented of the start-up and linear stability of pressure-driven channel flow of an elasto-viscoplastic fluid described by Saramito's constitutive law. Streamwise uniform base states are non-unique, depending on the initial stress configuration, and develop dis...

Synthesizability, hardness, and stacking order in multicomponent transition metal carbides from machine-learned potentials

Abstract Multicomponent transition metal carbides are promising for extreme-environment applications, but identifying compositions that are both synthesizable and hard remains challenging. We fine-tune the MACE machine-learned interatomic potential on approximately 28,000 density...

Redox regulation in O2 -tolerant [FeFe] hydrogenases: insights from two homologues

ABSTRACT O 2 -tolerance is a desirable property for [FeFe] hydrogenases, which are highly efficient H 2 -producing catalysts. While most such enzymes are highly sensitive to aerobic environments, a small number of explored representatives exhibit exceptional stability and even H...

Beyond psychedelic exceptionalism: how people combine meditation with psychoactive substances, and how this relates to well-being

Abstract Background Combining meditation with psychoactive substances is often assumed to be a niche practice centred on classic psychedelics. We sought to broaden this narrative in two cross-sectional studies. Methods Study 1 used a broad naturalistic sample (N = 1,391) to exami...

Efficient thermo-viscoplastic analysis using a multi-level hp-Finite Cell Method with non-negative moment fitting

An extension of the multi-level hp Finite Cell Method is proposed for the simulation of thermoviscoplastic problems with temperature-dependent material behavior. The approach combines hierarchical adaptive refinement with a non-negative moment fitting (NNMF) quadrature scheme for...

Allocentric navigation is computationally universal

I present three proofs that idealized neurocomputational architectures capable of navigation guided by allocentric maps with landmark structure can be computationally universal. Navigation may occur online, in the environment, or offline, in the animal's head. The first proof enc...

Tracking the lithiation state of LixSi from machine-learned XPS binding energies

Abstract X-ray photoelectron spectroscopy (XPS) is a powerful technique to probe chemical states and interfacial processes in battery materials, but a quantitative interpretation is often hindered by the complex, heterogeneous microstructures that form during operation and domina...

A Bayesian-guided aggregation-disaggregation algorithm for transit planning

Public transit is essential for daily mobility, especially for individuals without access to private vehicles. At the same time, designing efficient transit systems remains challenging when demand is spatially dispersed, density is low, and operational resources are constrained....

A new image similarity metric for a perceptual and transparent geometric and chromatic assessment

Full-reference image quality assessment metrics such as PSNR and SSIM misalign with human perceptual judgments on texture and shape distortions, a limitation documented across multiple benchmarks. Deep perceptual metrics such as LPIPS substantially close this gap but produce opaq...

Realisation of a protected cat-qutrit manifold via engineered quantum tunnelling

Engineering quantum tunnelling in phase space has emerged as a viable method for creating a protected logical qubit manifold with biased-noise properties. A promising approach is to combine a Kerr nonlinearity with a multi-photon drive, resulting in a system known as a Kerr param...

De novo design of protein binders targeting the human sweet taste receptor as potential sweet proteins

Excessive consumption of dietary sugars is a major contributor to metabolic disorders, driving global interest in finding alternative sweeteners with reduced caloric impact. Natural sweet proteins, such as brazzein, offer exceptional sweetness intensity with little caloric contri...

Streptomyces chodovensis sp. nov.: a novel candidate for plant growth-promoting actinomycete from bare soil developing on Miocene lacustrine sediment of the Sokolov Coal Basin, Czech Republic

Abstract A novel actinomycete, designated as BCCO 10_0861 T , was isolated from overburden Miocene clay sediments undergoing primary succession in Northwest Czechia and characterized by the polyphasic approach. According to 16S rRNA gene sequence similarity, the strain was closel...

Bimetallic Coinage Metal Complexes of Tetradentate ortho ‐Ter‐arylene Ligands

ABSTRACT We report a series of photoluminescent bimetallic Cu(I), Ag(I), and Au(I) complexes supported by tetradentate donor‐acceptor ligands containing two monoanionic amide donors (D) and two aza‐arene acceptors (A). The metal complexes of the ligand containing carbazolide and...