Research works

Prospective analysis of pre-diagnostic untargeted plasma metabolomics and risk of triple-negative breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Triple-negative breast cancer (TNBC) accounts for 10–15% of newly diagnosed breast cancer, and its aetiology is poorly understood compared to other breast cancer subtypes. We applied untargeted metabolomics to identify novel biological pathways associated with TNBC risk and poten...

Sequential skin cancer therapy

Background: Skin cancer, particularly melanoma, poses a significant global health challenge due to late diagnosis and treatment resistance. Current therapies often lack personalization and fail to address tumor heterogeneity. Objective: To propose SEQ-SKIN, a sequential integrate...

Neutrophil heterogeneity and crosstalk with cerebral-resident cells: therapeutic targets for ischemic stroke

Acute ischemic stroke elicits a robust inflammatory response within the brain. As one of the first peripheral immune cells to infiltrate the ischemic parenchyma, neutrophils show high heterogeneity and engage in complex crosstalk with resident brain cells. In this review, we firs...

Activation of the gluteus maximus and multifidus muscles in bridge and hip thrust exercise variations

Background The gluteus maximus (GM) and multifidus (MF) play important roles in maintaining the stability and mobility of the lumbopelvic-hip complex during various activities. Variations in bridge and hip thrust exercises can affect muscle activity in the GM, MF, and biceps femo...

First-Principles Study of Cs2TlCoX6 (X = I, Br): Structural Stability, Electronic, Elastic, and Optoelectronic Properties

Abstract In this study, density functional theory (DFT) is employed to investigate the structural, electronic, and optical properties of the double perovskites Cs2TlCoX6 (X = I, Br). The crystal structures of these materials are optimized to evaluate their structural stability. T...

Surgical management of cecal volvulus: a case report

A volvulus occurs when a loop of the intestine twists around itself and the supporting mesentery, accounting for 1–1.5% of all intestinal obstruction cases. Approximately one quarter of the colonic volvuli are cecal, with women being up to 80% of the cases. Surgical intervention,...

Factors Associated with Trust and Likelihood of Participation in Pandemic-Related Clinical Trials Among Blacks in the U.S. Deep South

Recruitment for clinical trials among Black populations in the U.S. Deep South is challenging due to general distrust of medical research. The COVID-19 pandemic exacerbated this phenomenon at a time when distrust of the medical community was high. This study evaluated the likelih...

Human health risk assessment of PM 2.5 -bound heavy metals during a haze season in a semi‑urban agricultural area of Northern Thailand

This study assessed PM2.5-bound heavy metals (Cd, Pb, Cr, Cu, and Fe) and associated human health risks at a semi-urban-agricultural site in Phitsanulok, lower northern Thailand, during the 2024–2025 haze season. Enrichment factors (EF), geoaccumulation index (Igeo), and US EPA h...

rRNA 5′ETS processing contributes to nucleolar organization and nuclear architecture

The eukaryotic nucleolus is a highly organized, multilayered structure essential for ribosomal RNA (rRNA) processing and ribosome assembly. While rRNA transcription is known to drive nucleolar assembly, the contribution of downstream processing steps to nucleolar organization rem...

Sociolinguistic identity and patterns of language use among bilingual preschoolers

Bilinguals navigate a dynamic, multifaceted, and intrinsically linked language-identity relationship. The present study explores how sociolinguistic identity relates to patterns of language use among 104 Russian-Hebrew bilingual children (ages 65–81 months) attending Hebrew-speak...

Transthoracic drainage of lung abscesses (TOLA): protocol for a national multicenter randomized open-label trial

Introduction Lung abscess (LA) is a rare but severe necrotizing pulmonary infection associated with substantial morbidity and mortality. Current management relies on prolonged systemic antibiotic therapy without systematic use of abscess drainage. However, small case series and r...

Seeing, hearing, and moving: Inequalities in assistive device use and health outcomes among older adults in India

Functional limitations related to hearing, vision, and mobility are common among older adults and may adversely affect mental health and functional independence. However, nationally representative evidence from India on assistive device use, unmet need, and related health outcome...

EuroMillions Breakthrough Mining — 1652 Sources, 11999 Leads Extracted — E8 Intelligence Research

Mined 1652 lottery+quantum breakthroughs. Extracted 11999 leads across 13 categories. 10017 high-value leads found. Categories: {"CORRIDOR": 993, "FORMULA": 837, "GEOMETRIC": 718, "FORWARD_ATTEMPT": 1042, "QUANTUM": 1255, "TIMING": 204, "CELESTIAL": 921, "GEMATRIA": 989, "CONSTAN...

Coherent Ergotropy and Quantum Fisher Information: An Exact Two-Level Identity, a Non-Universal Fisher Bound, and an Anisotropic Coherence Horizon

The coherent ergotropy of a quantum system—the work extractable by unitary control that is stored in energy-basis coherences—is usually treated as a purely thermodynamic quantity. This preprint establishes its exact geometric content for a two-level system and precisely delineate...

Hawking Radiation and Impermanence: 3 Ways Modern Physics Confirms What Ancient Wisdom Always Knew

This article examines three specific convergences between modern theoretical physics and ancient wisdom traditions on the nature of impermanence, emptiness, and information preservation. Convergence 1 (Hawking Radiation and Anicca): Hawking S (1974, Nature 248:30) derived that bl...

Middle atmosphere chemical and dynamical effects in the CCMI-2022 stratospheric aerosol injection scenario

Abstract. Stratospheric aerosol injection (SAI) could slow surface warming, however, potential side effects include changes in stratospheric ozone and changes in regional surface temperatures and precipitation resulting from tropical lower stratospheric warming. Previous multi-mo...

Effectiveness of mepolizumab in eosinophilic asthma and chronic rhinosinusitis with nasal polyps.

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory disease affecting 2-4% of the population which has a significant impact on quality of life. Approximately 40% to 60% of people with CRSwNP also have eosinophilic asthma, reflecting the unified airway conc...

MASS CODE 2026: AUTONOMOUS SHIPPING GOVERNANCE AND THE GLOBAL SOUTH

In May 2026, the International Maritime Organization (IMO) adopted the Maritime Autonomous Surface Ships Code (MASS Code) through Maritime Safety Committee resolution MSC.595(111), establishing the first international regulatory framework for autonomous cargo shipping (Internatio...

A study protocol for developing an implementation strategy bundle to enhance adoption of pediatric familial hypercholesterolemia screening

Familial hypercholesterolemia (FH) is the most common primary lipid disorder of childhood, affecting 1 in 250–350 children. Universal childhood cholesterol screening is an opportunity for earlier and more effective FH diagnosis and treatment that is superior to adult screening in...

From Comprehensive Distrust to Unquestioned Trust in Street-based Outreach Work With People Who Use Drugs in Finland

People who use drugs may experience comprehensive distrust in other people due to drug-related stigma and other violating experiences in services and in their life course. This may prevent them from seeking help. The goal of strengthening trust in services has been supported in s...