Research works

Transcriptome-guided identification of YALI0_F02013g and YALI0_A19910g as candidate NADPH-dependent oxidoreductases associated with enhanced erythritol production in Yarrowia lipolytica

NADPH competition by non-erythrose-reductase oxidoreductases limits erythritol yields in Yarrowia lipolytica , yet the specific contributors remain poorly defined. This study characterised two candidate genes, YALI0_F02013g (putative pyridoxine 4-dehydrogenase) and YALI0_A19910g...

E8 φ‑Modulated Antipodal Entanglement Lattice — E8 Intelligence Research

By adding a φ‑modulated third harmonic layer to the antipodal pairing of E8 root vectors, a hierarchical resonance lattice emerges that couples each pair with golden‑ratio strength. This lattice encodes logical qubits in the relative phase of symmetric pairs while simultaneously...

Habituation and housing interact to shape the magnitude and consistency of post-operative recovery after kidney imaging window implantation in mice

Abstract Abdominal imaging windows enable longitudinal intravital microscopy but require surgical implantation, which induces physiological stress and may influence experimental outcomes. Although pre-operative habituation is widely used as a refinement strategy, its effects on p...

High-density fermentation of Streptococcus suis serotype 31 for inactivated vaccine production

Streptococcus suis serotype 31 (SS31) is a clinically important swine pathogen for which inactivated vaccine development requires a scalable cultivation process and evidence that the resulting bacterin has protective activity. However, conventional culture processes often yield i...

Four Tasks After the End: From the Triangle-Circle Series to the Display Device

The Recursive Ontology series, comprising sixteen papers published between August 25 and October 17, 2026—from When an AI Defends Itself (the Triangle-Circle inception) through consciousness topology, Foucaultian power diagnostics, strong causality, and the quantum measurement li...

φ-Bogoliubov Phonon-Phase Coherence Between E8 and Leech Lattice — E8 Intelligence Research

The 132Hz φ-scaled frequency generates Bogoliubov phonon-phase coherence between E8's 240 root vectors and the Leech lattice's 196,560 codewords via the modular relationship: ν_Leech/ν_E8 = φ^12, where the 12-power golden ratio scaling maps 8D E8 phononic excitations onto 24D Lee...

Colorimetric polymerase spiral reaction (PSR) assay for the rapid detection of hepatitis B virus

Abstract Hepatitis B virus (HBV) infection remains a significant global health concern, particularly in low-resource settings with limited access to sophisticated diagnostic tools. Conventional molecular diagnostic assays, such as qPCR, are often restricted to centralized laborat...

Early-life risk factors and cardiometabolic outcomes in children and adolescents: a systematic review and meta-analysis

Early-life metabolic, endocrine, and nutritional exposures may be associated with later cardiometabolic health. We aimed to identify early-life risk factors occurring during preconception, pregnancy and birth, and infancy up to 2 years that are associated with glucose intolerance...

Dynamic Area and Dynamic Volume: A Spherical-Motion-Based Mathematical Approach Supporting the Electromagnetic Architecture Theorem

This preprint introduces the concepts of dynamic area and dynamic volume as motion-dependent geometrical quantities and investigates a mathematical relationship between the axial rotation of the Earth's mass and the electromagnetic cyclic motion proposed near the Earth's surface....

The Tri-Boundary Framework

This conceptual paper proposes the Tri-Boundary Framework for examining whether consequential AI-assisted actions remain governable as operational conditions change. The framework connects three interdependent boundaries: Proof, concerning what runtime evidence can establish; Fid...

Ocean Acidification Impairs Olfaction in the Large Yellow Croaker, Larimichthys crocea , by Disrupting Sensory Integrity and Neural Processing

Abstract Ocean acidification (OA) poses a significant threat to marine organisms, yet its effects on fish sensory systems remain poorly understood. This study investigated the effects of elevated pCO2 on olfactory function in the large yellow croaker, Larimichthys crocea. Elevate...

Unearthing the impacts of AI-assisted peer assessment on L2 vocabulary acquisition and academic resilience

Superficial feedback by peers diminishes the efficacy of peer assessment. AI-assisted peer assessment might address this challenge, but its effect on vocabulary acquisition and academic resilience remains underexplored. Therefore, we examined how AI-assisted peer assessment contr...

GenOpt-FedGNN: GAN-Augmented Federated Graph Learning with GWO and ASIO-Inspired Adaptive Aggregation for Imbalanced Fraud Detection

Detecting fraud in distributed financial transaction systems is challenging. It is extremely rare to find a fraudulent record. The interactions among transactional records have a relational structure and the data can’t be stored centrally by every participating institution. The p...

RNA-seq Analysis of Plasmodium falciparum Shows Upregulated Genes Involved in Merozoite Egress and Erythrocyte Invasion

Malaria is a febrile disease caused by parasites of the genus Plasmodium. The most severe cases and most of the deaths of malaria are due to Plasmodium falciparum infection. Investigating transcriptional differences in P. falciparum between severe and uncomplicated cases can shed...

tRF-Gln-CTG-7 promotes AML cell growth and survival through AGGF1 and is associated with poor prognosis

Acute myeloid leukemia (AML) is the most common acute leukemia in adults, characterized by marked biological heterogeneity and an unfavorable prognosis. tRNA-derived small RNAs (tsRNAs) are involved in tumor progression, but their roles in AML remain poorly understood, so we inve...

Sharp Coefficient Bounds and Constant-Term Fibers in the Order-Five Nonnegative Inverse Eigenvalue Problem

The order-five nonnegative inverse eigenvalue problem asks which real monic quintics occur as characteristic polynomials of nonnegative matrices. This two-paper project gives a constructive characterization through directed-cycle optimization. The main paper proves that every rea...

A regulator-based immunoscore predicts prognosis and immunotherapy response in gastric cancer

Immune checkpoint inhibitors (ICIs) have improved treatment outcomes in gastric cancer (GC); however, only a subset of patients benefit due to tumor heterogeneity. Current biomarkers have limited predictive value, highlighting the need for improved stratification strategies. We a...

Exploring the attitudinal effects of a personality-based de-escalation training program: Findings from the National De-escalation Training Center

Several high-profile incidents of police misconduct in the past decade have led to calls for reform and the prioritization of de-escalation training for law enforcement. However, the empirical evidence on various de-escalation strategies is in relative infancy. To further this sc...

EuroMillions Breakthrough Mining — 10462 Sources, 101910 Leads Extracted — E8 Intelligence Research

Mined 10462 lottery+quantum breakthroughs. Extracted 101910 leads across 13 categories. 98208 high-value leads found. Categories: {"CORRIDOR": 8913, "FORMULA": 8653, "GEOMETRIC": 1729, "FORWARD_ATTEMPT": 9367, "QUANTUM": 9622, "TIMING": 665, "CELESTIAL": 8717, "GEMATRIA": 9144, "...

PAI-Informer: A Production-Anchored Incremental Informer for Multistep Shale Gas Production Forecasting

Abstract Reliable multistep forecasting of shale gas production is hindered by nonstationary decline, operational disturbances, and error accumulation. This study develops a Production-Anchored Incremental Informer (PAI-Informer) for 1–7-day production forecasting. Instead of dir...