Research works

Liver-specific amino acid metabolism impacts on efficacy of cancer immunotherapy

Abstract The combination immunotherapies, including those with atezolizumab and bevacizumab (Atez/Bev), have become standard therapy for hepatocellular carcinoma (HCC). However, its efficacy remains limited and reliable biomarkers are lacking. In this study, we analyzed paired tu...

BRD4-S reprograms glutathione metabolism to reduce ferroptosis sensitivity and limits oxaliplatin response in gastric cancer

Abstract Background Bromodomain-containing protein 4 (BRD4) exists as distinct isoforms with potentially different biological functions, but their roles in ferroptosis and chemotherapy response in gastric cancer (GC) remain poorly understood. Here, we investigated the isoform-spe...

Advanced gestational trophoblastic neoplasm favoring placental site trophoblastic tumor, presenting with multiple metastases to the lung, pancreas, and liver as initial manifestations: a diagnosis-oriented case report

Abstract Placental site trophoblastic tumor (PSTT) is a rare subtype of gestational trophoblastic neoplasia (GTN), originating from intermediate trophoblasts at the implantation site. Its clinical presentations are often atypical, leading to misdiagnosis and delayed diagnosis, an...

Experimental investigation and multi-objective optimization of key control parameters for low-emission heavy-duty hydrogen engines

With the increasing global energy demand and the advancement of carbon neutrality goals, efficient and low-carbon power systems have attracted extensive attention in heavy-duty engine research. Hydrogen, as a clean and sustainable fuel, shows considerable potential for heavy-duty...

Size-dependent catalysis of Ru nanoparticles for selective reductive amination of PET plastic

Converting waste polyethylene terephthalate (PET) plastic into high-value p-xylylenediamine (PXDA) is a revolutionary solution to alleviate energy shortages and plastic pollution. However, current catalytic methods are often limited by poor chemoselectivity due to uncontrolled re...

Cross‐cultural adaptation and initial evaluation of selected measurement properties of the simplified chinese version of the knee injury and osteoarthritis outcome score joint replacement in patients with knee osteoarthritis

Abstract Purpose This study aimed to translate and culturally adapt the knee injury and osteoarthritis outcome score joint replacement (KOOS‐JR) into simplified Chinese and provide an initial evaluation of selected measurement properties in patients with knee osteoarthritis (OA)...

Ampicillin Resistance is Increased in Escherichia coli K12 relA and spoT mutants but Sub-inhibitory Pretreatment Does Not Induce Adaptive Resistance

The genes relA and spoT of Escherichia coli are required for the production of guanosine tetraphosphate, a critical molecule for the adoption of a stringent state that minimizes harm during metabolic and environmental stress. Subinhibitory treatments of antibiotics have been show...

Historical dynamics of social adaptation strategies under natural hazard characteristics in the Hengduan Mountains, Southwest China

The nexus between natural hazard events and regional societal responses constitutes a critical link in the chain of climate change impacts on human social systems. China’s extensive historical documentary resources remain underutilized for reconstructing spatiotemporal patterns o...

Abrupt vegetation shifts and their drivers in Arid Central Asia

Dryland vegetation responses to environmental change may be nonlinear or abrupt rather than gradual. However, long-term vegetation studies have largely focused on linear trends, leaving abrupt trajectories and their nonlinear environmental associations in Central Asian drylands i...

EuroMillions Breakthrough Mining — 10482 Sources, 102083 Leads Extracted — E8 Intelligence Research

Mined 10482 lottery+quantum breakthroughs. Extracted 102083 leads across 13 categories. 98375 high-value leads found. Categories: {"CORRIDOR": 8928, "FORMULA": 8666, "GEOMETRIC": 1733, "FORWARD_ATTEMPT": 9386, "QUANTUM": 9639, "TIMING": 668, "CELESTIAL": 8731, "GEMATRIA": 9160, "...

Insights Concerning Situation Awareness From Airport Personnel During Routine and High-Demand Events

This study surveyed how airport employees perceive and maintain situation awareness (SA) during both routine and high-demand events. Fourteen airport employees across departments (Administrative and Operational) were interviewed to identify the differences across environmental/pe...

T4 Bacteriophage Average Burst Size Varies with Escherichia coli B23 Cell Culture Age

Host physiology has a dramatic effect on the ability of T4 bacteriophage to infect and produce progeny. Previous studies have shown that as Escherichia coli cells enter stationary phase, many physiological changes to cell size and shape occur. These changes could affect the abili...

Babylonian Base-60 Math and the 360-Day Year: No Direct Intercalation Algorithm Found — E8 Intelligence Research

FINDING: The search results confirm base-60 (sexagesimal) as the foundational arithmetic system of Babylonian mathematics, directly tied to time measurement and the 360-day year, but provide no direct reconstruction of the MUL.APIN intercalation algorithm itself. MATH: - Base-60...

Dyadic coping and factors associated with prenatal depression and anxiety profiles: a couple-level latent profile analysis study

The transition to parenthood is a critical period for psychological adjustment in both partners. While dyadic coping (DC) plays a central role in regulating stress within couples, few studies have explored how joint coping patterns relate to distinct combinations of maternal and...

Babylonian Intercalation Cycle: No Direct Evidence Found in Retrieved Sources — E8 Intelligence Research

FINDING: The search results are primarily video/lecture links and an ML paper on cuneiform sign classification — none directly address the Babylonian intercalation Metonic cycle or the 7/19 ratio derivation. No primary cuneiform text or mathematical derivation of the 7/19 interca...

The mediating role of health literacy between information overload, risk perception, and health information avoidance

This study examines how external stimuli (e.g., information overload, risk perception) interact with internal emotional states (e.g., health information anxiety and sadness) to trigger health information avoidance (behavioral outcomes/response), with health literacy as a mediator...

Dynamic analysis of floodplain degradation in the Andong Dam Reservoir, Korea from a socio-hydrological perspective

This study investigates the mechanisms underlying floodplain degradation in dam reservoirs from a socio-hydrological perspective. Specifically, it aims to understand how human behavior, flood dynamics, and policy interventions interact to influence long-term changes in floodplain...

Structured postmortem genetic counselling and testing in sudden unexplained death among young adults in the Netherlands: results and implications regarding hereditary risk

Abstract Introduction Sudden unexplained death (SUD) in young adults may result from hereditary cardiovascular disorders that remain undetected even after conventional autopsy. Routine postmortem genetic testing may identify these disorders, improving determination of the cause o...

YOLO11-DAL a multi-scale fusion network for target detection in UAV-based power line inspection

Abstract Reliable detection of transmission-line components and defects in unmanned aerial vehicle (UAV) imagery supports preventive maintenance. Repeated downsampling, however, removes fine spatial detail, while limited interaction between feature levels hinders small-object det...

Innovation and performance of microenterprises during crisis and post-crisis periods: a comparative analysis in a fragile economy

The COVID-19 crisis triggered a rapid reconfiguration of entrepreneurial activities worldwide. In Chad, where microenterprises constitute the backbone of the economy and operate under severe resource constraints, innovation emerged as an important adaptation mechanism. This study...