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CHALLENGES IN USING PHARMACOMETRICS MODEL IN DOSING MERCAPTOPURINES IN LEUKEMIA

Mercaptopurine (6‑MP) is a key component of maintenance therapy for acute lymphoblastic leukemia, but optimizing its dose is challenging due to large differences between patients in how the drug is metabolized and how they respond. This review discusses the pharmacometric models...

A STUDY TO ASSESS THE EFFECTIVENESS OF STRUCTURED TEACHING PROGRAMME ON KNOWLEDGE REGARDING CRASH CART AMONG THE 4TH YEAR BSC NURSING STUDENTS AT SELECTED NURSING COLLEGE, MYSURU

A pre-experimental one-group pre-test and post-test study was conducted to assess the effectiveness of a structured teaching programme on knowledge regarding crash cart among 4th year BSc Nursing students at a selected nursing college, Mysuru. The objectives of the study were to...

RASOUSADHI AS MICRONUTRIENT SUPPLEMENT: AN INTEGRATIVE APPROACH THROUGH DHATU SIDDHANTA

Micronutrient deficiency remains a major global health challenge, with a significant proportion of the population lacking essential nutrients such as iron, zinc, vitamin D, and vitamin B12, despite widespread use of fortified foods and synthetic supplements. Organically derived n...

EVALUATION OF ALLOXAN INDUCED ANTI-DIABETIC ACTIVITY OF CROTON CAJUCARA LEAF AND ROOT EXTRACTS

The present study aimed to evaluate the in vitro and in vivo antidiabetic potential of ethanolic leaf and root extracts of Croton cajucara using alloxan-induced diabetic Wistar rats. Leaves and roots of Croton cajucara were sequentially extracted using petroleum ether, ethyl acet...

FORMULATION AND EVALUATION OF HERBAL ANTI ACNE CREAM

Acne is a common skin disorder predominantly found in adolescents and young adults and has considerable psychosocial effects. Conventional treatments, including benzoyl peroxide, retinoids, and antibiotics, often involve side effects, such as skin irritation, dryness, and the ris...

AYURVEDIC MANAGEMENT OF CHRONIC SCALP PSORIASIS (EKA KUSHTA) THROUGH SHAMANA CHIKITSA: A CASE REPORT

Psoriasis is a chronic, immune-mediated inflammatory skin disorder affecting 2–3% of the global population, with scalp involvement being a common, persistent manifestation that follows a relapsing-remitting course requiring long-term management. In Ayurveda, its features resemble...

FORMULATION AND EVALUATION OF MATRIX TYPE TRANSDERMAL PATCH OF DICLOFENAC SODIUM

Background: The clinical and biopharmaceutical utility of oral Diclofenac Sodium is severely constrained by its exceptionally short biological half-life (1.2 to 2.0 hours) and a high incidence of gastrointestinal systemic complications, including mucosal ulceration, localized ble...

NETRA VARTI IN AYURVEDA- AN IN-DEPTH REVIEW OF TRADITIONAL OPHTHALMIC WICKS AND THEIR THERAPEUTIC USES

Background: Shalakya Tantra (branch of Ayurveda dealing with diseases above the clavicle) emphasizes the management of ocular disorders due to the importance of the eyes as essential sense organs. Ayurvedic formulations such as Netra Varti (ophthalmic wick) serve as localized med...

BRONCHIAL ASTHMA:: HOMEOPATHIC APPROACH

Bronchial asthma is a chronic inflammatory disease of the airways characterized by reversible airflow obstruction, bronchial hyper-responsiveness, and recurrent episodes of wheezing, dyspnoea, chest tightness, and cough. Climatic conditions, particularly the monsoon season, signi...

THE SCIENCE, PRACTICE, AND FUTURE OF YOGA FOR CHILDREN: A REVIEW ARTICLE

Background: In recent years yoga is more and more practiced by the children and adolescents in educational, community, and healthcare settings and studied for possible positive impact on physical, psychological, cognitive, and behavioural parameters. However, there is great varia...

PHARMACEUTICAL WASTE MANAGEMENT

Pharmaceutical waste management is an important part of the healthcare system that helps protect human health and the environment. The pharmaceutical industry produces different types of waste, such as expired, unused, contaminated medicines, and packaging materials. If these was...

INTER-RELATIONSHIPS WITH MODERN SCIENCE AND CLINICAL RELEVANCE OF SAPTA DHATU

Ayurveda, one of the oldest systems of medicine, originated in India over 5,000 years ago. It is a comprehensive system of healthcare that focuses on achieving optimal health and well-being through a holistic approach, encompassing the physical, mental, and spiritual aspects of a...

A REVIEW ON RECENT TREATMENT OF HIV PATIENTS

Key Global Statistics - PLHIV – Approx. 40.8 million. - New HIV infections – 1.3 million(roughly a 40% reduction since 2010). AIDS Related Deaths Roughly 630,000 people died from HIV-related causes in 2022, down from the 2004 peak. Total Historic Impact: The impact of Human Immun...

MICROSPHERE-BASED DRUG DELIVERY SYSTEMS: A COMPREHENSIVE REVIEW

The targeted drug delivery is designed for endeavoring to concentrate the drug in the tissues of curiosity while reducing relative concentration of medication in the remaining tissues. There for drug is localized on the targeted site. Hence, surrounding tissues are not affected b...

CUSHING'S DISEASE IN A YOUNG ADULT WITH ADRENAL INCIDENTALOMA: A DIAGNOSTIC ODYSSEY THROUGH BIOCHEMICAL AND RADIOLOGICAL WORKUP

Cushing’s disease, resulting from ACTH-dependent hypercortisolism driven by a pituitary corticotroph adenoma, represents a diagnostically challenging endocrine disorder. We report the case of a 29-year-old male who presented with dyspnea and was found to have features of cortisol...

VITILIGO IN FOCUS: A COMPREHENSIVE REVIEW OF ETIOLOGY, DIAGNOSIS AND MANAGEMENT

In world about 0.5% -2% populations got affected by Vitiligo depigmenting cutaneous disorder. Vitiligo is characterized by loss of melanocytes like chalky white patches, non scaly macules. There are following main causes of Vitiligo first is reduced reaction to touch allergen sec...

DEVELOPMENT AND EVALUATION OF ENTERIC-COATED PANTOPRAZOLE TABLETS FOR ENHANCED GASTRIC PROTECTION

Pantoprazole is a proton pump inhibitor widely used in the management of acid-related gastrointestinal disorders, including gastroesophageal reflux disease, peptic ulcer disease, and Zollinger–Ellison syndrome. Because Pantoprazole is highly unstable in acidic conditions, an ente...

A RANDOMIZED OPEN LABELLED CONTROL CLINICAL STUDY TO EVALUATE THE EFFICACY OF MADHUKADI TAIL KARNAPOORNA AND APAMARGKSHAR TAIL KARNAPOORNA ALONG WITH GOGHRITA ORALLY IN THE MANAGEMENT OF KARNANADA (TINNITUS)

Micronutrient deficiency remains a major global health challenge, with a significant proportion of the population lacking essential nutrients such as iron, zinc, vitamin D, and vitamin B12, despite widespread use of fortified foods and synthetic supplements. Organically derived n...

ASSESSMENT OF VISUAL IMPAIRMENT IN PRIMARY SCHOOL CHILDREN AND EFFECTIVENESS OF SCHOOL VISION SCREENING PROGRAMS IN KARBALA, IRAQ

Introduction: Visual impairment in children is a significant public health challenge, particularly in low- and middle-income countries where early detection programs are often underdeveloped. Method: This study aimed to assess the prevalence and causes of visual impairment among...

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR ESTIMATION OF IMEGLIMIN IN BULK AND PHARMACEUTICAL DOSAGE FORM

Imeglimin Hydrochloride is a novel anti-diabetic drug used in the management of Type 2 Diabetes Mellitus. The present study focuses on the development and validation of a simple, precise, accurate, and economical Reverse Phase High-Performance Liquid Chromatography (RP-HPLC) meth...