Research works

The digital native fallacy: how age-based assumptions exclude young adults with chronic disease from digital health innovations

Digital health interventions often rely on a “digital native” assumption of inherent user competence and stable access. Drawing on US-based evidence, we challenge this: social media fluency does not equate to health literacy 1 , digital access is structurally unstable 2 , and ins...

Comparison of Cup-to-disc Ratio Estimates Using Wide Field Fundus Photography and Optical Coherence Tomography

Purpose: We compared cup-to-disc ratio estimates obtained using wide-field fundus photography and optical coherence tomography (OCT), both of which are widely used for fundus examination.Methods: In total, 130 eyes from 65 patients were included and categorized as 53 right eyes a...

Performance Evaluation of IMERG and GSMaP Hourly Precipitation Products for Landfalling Typhoon Rainfall in China

This study systematically evaluates the performance of GPM_IMERG and GSMaP_Gauge hourly precipitation products in typhoon rainfall over Mainland China. Using hourly gauge observations from the China Meteorological Administration (CMA)’s national basic meteorological stations as r...

Analytical Validation of Bacopa monnieri Extract through High-performance Thin-layer Chromatography with Emphasis on Spasmolytic Phytomarkers

Background: Bacopa monnieri (Brahmi) is a traditional Ayurvedic herb widely reported for memory-enhancing, anti-inflammatory, and antispasmodic properties.Fingerprint profiling of extracts by high-performance thin-layer chromatography (HPTLC) ensures quality control and supports...

Revisiting the activate depress free and repeat (ADFR) paradigm: Clinical use of cyclic romosozumab

Abstract Summary Osteoporosis treatment does not normalize BMD. We hypothesized cyclic romosozumab dosing might provide greater BMD increases. Cyclic therapy (six romosozumab monthly doses then one denosumab dose) produced broadly similar BMD increases as previously reported for...

MODEL ADOPTION #1023: REJECT — LEDGER BENCH: Apply filter: Quarterly phase = MANIPULATION — improves win rate from 31.5% — E8 Intelligence Research

DECISION: REJECT ELEMENT: The MANIPULATION phase filter is not a concrete, testable edge compatible with E8 geometry timing — it is a calendar-based heuristic that introduces temporal overfitting and cannot be reliably synchronized with Gods-Clock rhythm logic. The +0.5pp win-rat...

Design, Synthesis,and Fungicidal Activity of Novelα-Methylene-γ-Butyrolactone Derivatives BearingBenzofuran-2-yl Moiety

Abstract A series of 30 novel α-methylene-γ-butyrolactone (MBL) derivatives were designed and synthesized. Bioassays revealed that several compounds exhibited potent fungicidal activities against Valsa mali, Rhizoctonia solani, and Phytophthora capsici. A25 showed the highest act...

GDP-Loaded K-RasTransiently Binds to EffectorB-Raf RBD, Mirroring the Structure of the Active GTP-LoadedComplex

Abstract The Ras-Raf protein association initiates the downstream mitogen-activated protein kinase (MAPK) signaling cascade. This interaction depends on the Ras-nucleotide ligand, whereby Raf preferentially binds to the active guanosine triphosphate (GTP)-loaded state over the gu...

Constraints and opportunities: The case of the first French professional female rugby players

This study aims to address the lack of research on the dual-career experiences of the first generation of professional female rugby players in France. Specifically, it examines (1) the current status of professional female rugby players and (2) how they combine their rugby career...

The hematology workforce in the United States: past, present, and strategies for the future

From 2017-2021, the American Society of Hematology (ASH) completed the largest study ever conducted of the hematology workforce in the United States (US). The study highlighted a deficit in the classical hematology (CH) workforce: despite very high CH clinical volumes encountered...

Preoperative FIB ‐4 Index as a Potential Factor Associated With Severe Postoperative Complications and Endogenous Organ Failure After Hepatectomy for Hepatocellular Carcinoma

ABSTRACT Background Liver fibrosis influences tolerance to surgical stress, dictating postoperative complication risks after hepatectomy for hepatocellular carcinoma (HCC). While conventional systems assess hepatic function, they may not fully capture structural fibrosis. This st...

The Impact of AI Voice Tutors on Phonetic Acquisition Among Saudi EFL Learners: A Quasi-Experimental Study at Jouf University

Abstract This study investigates the impact of AI-powered voice tutors on the phonetic acquisition of Saudi EFL learners. Although digital technologies are increasingly integrated into language education, empirical research has yet to examine the extent to which AI-driven pronunc...

Behavioral Improvement and Task-Related Brain Activation Following Cognitive Training in Children/Adolescents and Young Adults: A Three-Level Behavioral and Coordinate-Based Neuroimaging Meta-Analysis

Background/Objectives: Cognitive training provides a framework for examining how repeated practice relates to changes in cognitive performance and task-related brain activation, yet age-stratified patterns of neural effects remain unclear. Methods: We conducted a three-level beha...

Merkel cell carcinoma: A clinically oriented mini-review for dermatologists

Background: Merkel cell carcinoma (MCC) is a rare but highly aggressive cutaneous neuroendocrine malignancy with mortality rates exceeding melanoma at comparable stages. Its incidence is increasing worldwide, particularly among elderly, immunosuppressed, and fairskinned individua...

Comparative value of growth velocity and umbilical artery Doppler for the prediction of adverse perinatal outcomes in growth‐restricted pregnancies

Abstract Introduction Fetal growth restriction (FGR) is associated with an increased risk of neonatal morbidity and mortality. Current diagnostic criteria for FGR do not discriminate between constitutionally small and pathologically restricted fetuses. Following FGR diagnosis, um...

QTT Carrier-Deletion Finite-Window and Timing-Access Blind Test Extension

Erase the apparent carrier. Recover the qubit from its halo. Then ask a different clock. This preregistration separates an ordinary quantum-memory qualification from a distinct timing test. Test A evolves a logical qubit through a frozen local channel, physically resets its origi...

Automated In-InjectorPort Conversion of AristolochicAcids to Aristolic Acids for Enhanced HPLC Fluorescence Detection

Abstract Aristolochic acids (AAs) and the herbs containing them are recognized human carcinogens. Emerging evidence indicates that AAs are also food and environmental contaminants, posing significant risks to human health. This study developed a highly sensitive AA detection meth...

Vitamin D and the accuracy of nuclear medicine imaging in patients with prosthetic hip and knee joints – a retrospective study

OBJECTIVE: Nuclear medicine is a well-established modality for assessing infection or loosening of prosthetic joint replacements. However, previous research suggests that loosening and low-grade periprosthetic infection can appear similar. Patients with vitamin D deficiency have...

Language Models as a Challenge for Business Ethics – A Partially Open-Source Approach

Abstract Large language models have become central infrastructures of contemporary digital economies while raising persistent ethical concerns regarding linguistic inequality, opacity, data governance, and the concentration of technological power. Much of the current debate on AI...

FORMULATION AND EVALVATION OF FAST DISINTEGRATING LOSARTAN POTASSIUM TABLETS BY NATURAL EXCIPIENTS

AbstractThe objective of the proposed research work is to prepare and evaluate the fast disintegratinglosartan potassium tablets by natural excipients, which avoids first pass metabolism, improvedthe dissolution rate and enhance the bioavailability. Losartan potassium isangiotens...