Research works

Menopausal arthralgia and longitudinal changes in sex hormones and climacteric symptoms

Musculoskeletal discomfort (menopausal arthralgia) is the most prevalent and debilitating complaint during the menopausal transition. Despite its high prevalence, menopausal arthralgia has historically been overlooked, and establishing a direct association with menopause remains...

The Psychoanalytic Criminal System (PCS): An Integrative, Recursive Framework for the Psychoanalytic Understanding of Criminal Behavior

Version 2.0 – Revised and Expanded Manuscript This revised version of The Psychoanalytic Criminal System (PCS) substantially expands the original framework by introducing a more comprehensive recursive model for the psychoanalytic understanding of criminal behavior. The manuscrip...

The effect of natural disasters on dyslipidemia: a nationwide study from China

Globally, dyslipidemia has become a leading risk factor for many adverse health outcomes, especially among middle-aged and elderly populations. Accumulating evidence suggests that environmental-level factors may also be associated with the risk of dyslipidemia. Although natural d...

High-throughput engineering of bispecific antibodies to enhance macrophage-mediated cytotoxicity of B-cell lymphoma

Abstract Macrophages are critical effectors of antibody therapies for lymphoma, but the best targets to engage their function remain unknown. Here, we develop a ‘tactical surfaceome profiling’ strategy to define a comprehensive repertoire of surface antigens on B-cell lymphoma th...

STUDIES ON THE BACTERIAL COMMUNITIES ASSOCIATED WITH COCKROACH (Periplaneta americana) SAMPLED FROM INDOOR SPACE AND THEIR ANTIBIOTIC RESISTANCE

Indoor cockroaches are potential carriers of pathogenic and antibiotic-resistant bacteria. This study examined bacteria present on the external surfaces of Periplaneta americana collected from indoor environments in Malappuram District, Kerala, India, and evaluated their antibiot...

Labour, land and the libidinal in the struggle for liveable futures

Ariel Salleh's book, DeColonize EcoModernism! is relevant to our contemporary times in terms of deepening geopolitical conflicts, naked resource imperialism and ‘might is right’ guiding international relations and – now being torn apart before our eyes. While Trump and Netanyahu...

Identification of Clinical and Radiologic Markers of Disease Presentation in Patients with Scleroderma Related Interstitial Lung Disease (SSc-ILD) in a Cohort from Ontario, Canada

Objectives Systemic sclerosis (SSc) is a multisystem autoimmune disease characterized by vasculopathy, inflammation and fibrosis of multiple organs including the skin, lungs, heart, and GI tract.[1] Lung involvement, characterized by interstitial lung disease (SSc-ILD) and pulmon...

3.6 Photon Zero-Mass Theorem

This article proves that the photon mass is strictly zero—— is an algebraic necessity of the Coding Orbit, without introducing gauge symmetry as a postulate. The photon corresponds to the dominant Eigenvalue of the ℳ sector self-coupling and does not participate in the breathing...

Development of an instrument for measuring university students’ motivation for sustainability engagement using self-determination theory

Sustainability education has become an important focus of higher education globally. However, the factors influencing students’ motivation to engage in sustainability-related activities, both within formal educational settings and in their broader communities, remain relatively u...

Psychiatric disorders and intellectual disability impact epilepsy care in adolescents: A nationwide registry study

Abstract Objective To investigate the associations of intellectual disability (ID) and psychiatric comorbidities with healthcare utilization and mortality among adolescents with epilepsy. Method A nationwide, population‐based observational study using the data from Swedish nation...

PSCS: Separating Semantic Content from Instructional Authority in AI Systems

Prompt injection exploits an AI system's failure to keep an instruction's meaning separate from its authority. The Pakheta Semantic Conduction System (PSCS) separates semantic recognition from operational permission through one central rule: content may contain instructions; cont...

Metabolic responses of diet–exercise combinations in women with obesity: a comparative lifestyle intervention study with different diet types

Obesity represents a major global public health challenge, particularly among women, and is associated with adverse metabolic and endocrine outcomes. his study evaluated the effects of ketogenic, intermittent fasting (IF), and semi-vegetarian diets, alone or combined with home-ba...

Determinants of Civil Servant Performance in Public Organizations: Examining the Moderating Effect of Organizational Culture on Workload–Leadership Relationships

ABSTRACT: This study aims to examine the effects of workload and leadership on Civil Servants’ (ASN) performance, with organizational culture serving as a moderating variable at the Regional Development Planning Agency (Bappeda) of Jember Regency. The study employed a quantitativ...

INTERDEPENDENCIES AND FEEDBACK LOOPS: INFORMATION-BASE FOR THE EFFECTIVE EVALUATION ON HOW NATURE AND ANTHROPOGENIC ACTIVITIES SHAPE GLOBAL HEALTH AND ENVIRONMENT IN ECOSYSTEM DYNAMICS (ECODYNAMÍCS)

Evaluating baseline ecodynamics necessitates mapping intricately ambiguous, non-linear feedback loops where, for instance, health and environmental determinants, ecological resilience, and socio-economic systems intersect. This establishes an analytical threshold to differentiate...

Icotrokinra (ICO), a Novel Targeted Oral Peptide, in Patients (Pts) with Psoriatic Disease: Exploratory Assessments from a Phase 2 Psoriasis (PsO) Study Informing a Phase 3 Clinical Program in Psoriatic Arthritis (PsA)

Objectives PsA affects ~20-30% of patients with PsO, causing articular inflammation and impaired quality of life. ICO, a novel targeted oral peptide that binds IL-23 receptor, showed greater clinical response rates vs placebo and a favorable safety profile in moderate-to-severe p...

Anaesthetic Management of a Spontaneous Haemorrhagic Stroke Following Severe Preeclampsia: A Case Report

Haemorrhagic stroke (HS) during pregnancy, especially in the context of preeclampsia, is a rare but critical emergency that poses significant health risks to both the mother and the foetus. Even so, rapid recognition and appropriate management are of utmost importance to minimise...

Bilateral Calcinosis Circumscripta of the Digits with Bone Involvement: A Case Report

Completed CARE reporting checklist for the accompanying F1000Research case report

From Substance to Relation: Three Paradigm Shifts in Physics and Their Falsifiability

Physics is commonly regarded as the science of “material substances and their laws of motion.” Yet, returning strictly to the operational essence of experimental science, physics has never verified any absolute substance independently of relational interactions. Taking Newtonian...

EuroMillions Breakthrough Mining — 947 Sources, 4914 Leads Extracted — E8 Intelligence Research

Mined 947 lottery+quantum breakthroughs. Extracted 4914 leads across 13 categories. 3113 high-value leads found. Categories: {"CORRIDOR": 366, "FORMULA": 225, "GEOMETRIC": 634, "FORWARD_ATTEMPT": 380, "QUANTUM": 595, "TIMING": 160, "CELESTIAL": 310, "GEMATRIA": 343, "CONSTANT": 3...

Clinical Relevance of Pelvic and Heel Enthesophytes in Psoriatic Arthritis

Objectives Enthesitis is a hallmark feature of psoriatic arthritis (PsA), but its clinical assessment can be confounded by subjective assessment and overlapping fibromyalgia. We aimed to investigate the clinical and functional associations of radiographic enthesophytes in a large...