Research works

CK2 targeting potentiates antineoplastic effects of dual HER2/EGFR inhibitor lapatinib and attenuates growth factor-induced epithelial-mesenchymal transition

CK2 is a pleiotropic, heterotetrameric kinase elevated in numerous cancers and, as such, has garnered much attention as a target for novel antineoplastic agents. Currently, silmitasertib, a selective CK2 inhibitor, has an orphan designation for medulloblastoma and neuroblastoma....

Seed germination of Schinus terebinthifolius as a function of fruit coloration

The present study aimed to evaluate the germination and germination speed index of Schinus terebinthifolius seeds obtained from fruits with different colors, considering the influence of different progenies. The study was conducted at the Federal Rural University of Pernambuco, i...

Longitudinal characterization of medial gastrocnemius muscle growth deficits throughout childhood in spastic cerebral palsy

The prospective longitudinal study compared muscle growth in children with spastic cerebral palsy (CP) with typically developing (TD) peers and across Gross Motor Function Classification System (GMFCS)-groups, and investigated muscle deficit trajectories across GMFCS-groups. Thre...

Recursive Contextual Closure: Longitudinal Loss of Epistemic Permeability in Persistent Human-AI Ecosystems (Position Paper)

Position paper, bilingual: full Hungarian and English texts included, with a supplementary evidence pack (hashed dated note exports, model-analysis annexes, architecture manifest, control-run documentation, claim-revision ledger, CITATION.cff). This paper names and operationalize...

Combining the vegetation indices and bionic optimization random forest for predicting SPAD values in maize leaves

Leaf Soil and Plant Analyzer Development (SPAD) is an important physiological index reflecting the healthy growth and development of maize. Accurate estimation of leaf SPAD by vegetation indices is of great significance for regulating maize growth, optimizing nutrient management...

Lensing Excess as a Geometric Projection: A No-Refit Prediction with \(A_{\rm rel}=19/15\)

We test whether the galaxy-galaxy lensing excess (where light appears to cross more geometry than massive tracers) follows a universal geometric conversion rather than a fitted dark matter halo amplitude. Derived from tensor projection identities, the leading optical closure pred...

Distribution and Fraction of Metal(Loid)s in Antimony Tailings Ponds and Their Effects on Naturally Recovering Local Vegetation and Microorganisms

Mining and smelting of antimony ores produce large quantities of tailings that pose significant environmental hazards. Plants and microorganisms exhibit adaptive responses to metal contamination in their habitats. In this study, we selected the Dachang Antimony Mine in Qinglong,...

Sex-Specific Correlates of Emotional Eating Among Arab Migrants

Acculturative stress, arising from cultural and psychological changes following intercultural contact, may increase vulnerability to maladaptive coping behaviors, including emotional eating. Evidence suggests that the association between acculturative stress and disordered eating...

Design of a deep learning-driven multidimensional evaluation model for youth training system performance assessment

In this paper, a deep learning driven multidimensional evaluation framework is proposed to evaluate the performance of Youth Training System (YTS). In order to reduce the subjectivity of manual scoring and static weight, the framework organizes resources organization, training ex...

The Mo, Tl, and U isotope paleoredox proxies: comparisons, contrasts, and future directions

Sedimentary molybdenum (Mo), thallium (Tl), and uranium (U) isotope ratios can potentially track global-scale changes to past ocean oxygenation levels. In this review we summarize and describe the unique strengths and weaknesses of these “paleoredox proxies”. We emphasize two cri...

MRgFUS-enabled nanogel platform for synergstic chemo-immunotherapy in glioblastoma

Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with poor prognosis and limited responsiveness to temozolomide (TMZ)-based chemoradiotherapy. Treatment remains hindered by the blood-brain barrier (BBB), blood-brain tumor barrier (BBTB), acquired TMZ resistance, a...

Clinical determinants of neonatal mortality at a tertiary hospital in a resource limited setting: a retrospective cohort study

Neonatal mortality remains a significant public health challenge in low-resource settings. Understanding the independent predictors of neonatal death is essential for developing targeted interventions and improving clinical outcomes. This study aimed to identify factors associate...

Operationalizing public health emergency operations centers in Somalia: a scoping review of challenges and strategies

Public Health Emergency Operations Centers (PHEOCs) are central to national health security systems, enabling coordinated preparedness, surveillance, and response to public health emergencies. However, their operationalization remains particularly challenging in fragile and confl...

Progress and persistent questions in understanding the origin of life on Earth

The origin of life remains one of the most challenging questions in Earth and planetary sciences, requiring integration of early planetary evolution, geochemical environments, and experimentally validated prebiotic chemistry. This review synthesizes current evidence from Hadean E...

Employment and disability: societal ableism, serendipity, and universal design (1919)

Drawing on the author’s lived experience, qualitative research, and policy analysis, this article discusses some issues experienced by disabled workers. It critiques the limitations of existing initiatives, such as Access to Work and the Disability Confident scheme, highlighting...

Manufacturing methods, properties and patent landscape of polylactic acid eggshell powder composites

This review synthesizes research on polylactic acid (PLA) composites incorporating eggshell powder (ESP) as a bio-based filler, with a focus on manufacturing methods, resultant material properties, and emerging patent trends. PLA, a widely adopted biodegradable thermoplastic deri...

Determinants of AMR-safe practice adoption among restaurant owners and managers in the Philippine food service sector

Antimicrobial resistance (AMR) represents an escalating global public health threat with direct implications for food safety governance and consumer protection. Yet empirical evidence on the awareness, practices, and structural determinants of AMR-safe behavior among food service...

Hierarchical federated edge learning with criticality-aware aggregation for privacy-preserving fetal health classification

The automated classification of fetal health from cardiotocographic (CTG) recordings is a crucial machine learning application in obstetric diagnostics. Although centralized predictive models have advanced significantly, their large-scale clinical deployment remains structurally...

Risk factors for incident chronic kidney disease following unilateral nephrectomy: a systematic review and meta-analysis

Nephrectomy is standard for kidney tumors and living kidney donation, but postoperative chronic kidney disease (CKD) is a critical determinant of long-term outcomes. Risk factors for incident CKD after unilateral nephrectomy remain incompletely synthesized. PubMed, Embase, Web of...

Insomnia severity predicts suicide attempts in youth with depression in China: a 6-month prospective cohort study

Evidence linking insomnia to suicidal risk in depressed youth is largely cross-sectional, limiting inference about temporal direction. We examined whether baseline insomnia severity predicts subsequent suicide attempts in this population. We conducted a 6-month prospective cohort...