Research works

Differences in health outcomes of orthopedic rehabilitation after hip or knee replacement: a prospective pilot study benchmarking 23 rehabilitation facilities using Patient-Reported Outcome Measures (PROMs)

Abstract Background Patient-reported outcome measures (PROMs) are increasingly used for benchmarking hip and knee arthroplasty, yet evidence on their feasibility for public reporting of short-term rehabilitation outcomes remains limited. International initiatives such as ICHOM re...

Autonomous intranasal delivery systems for central nervous system therapeutics

Intranasal delivery provides a rapid, non-invasive route to the central nervous system, bypassing the blood-brain barrier and first-pass metabolism. However, its therapeutic potential remains constrained by the nasal cavity's complex anatomy, the restricted surface area and perme...

Performance of mechanochemically activated supplementary cementitious materials in cement pastes and mortars

Abstract Mechanochemical activation (MCA) is a rapidly emerging technology for producing supplementary cementitious materials (SCMs). However, performance data on MCA SCMs is lacking. Here, we investigated the potential use of four low-grade materials as sources of alternative SC...

Endoscopic and combined approaches in the surgical management of frontal and ethmoidal sinus osteomas: a novel decision-making flowchart

PURPOSE: Paranasal sinus osteomas are benign but potentially symptomatic lesions whose management remains heterogeneous despite recent advances. Choosing between a purely endoscopic or a combined approach can be challenging, particularly for larger lesions. This study aims to pre...

Effects of photobiomodulation, alone or combined with dexamethasone, on cellular metabolic activity and inflammatory markers in LPS/IFN-γ-stimulated J774 macrophages

The aim of the present study was to investigate the effects of photobiomodulation (PBM), dexamethasone (DEXA), and their combination on cellular metabolic activity and inflammatory cytokines in LPS/IFN-γ-stimulated J774 macrophages.Cells were stimulated with lipopolysaccharide (L...

The Carlo Canon: A Unified Framework for Disturbance Evolution, Field Identity, Collapse–Reformation Dynamics, and Multi‑Layer Deduction Architecture

The Carlo Canon is a complete, multi‑document conceptual framework describing how disturbances evolve inside constraint‑bound fields across all domains. It unifies field ontology, disturbance taxonomy, invariant architecture, collapse and reformation operators, limit cycles, limi...

The Cascade of Inattention: Observability and Responsibility in Vertical Hierarchies

A companion working paper—the Equilibrium Without Collusion model (hereafter ewc; SSRN working paper, 2026)—showed that recurring control deficiencies can be an equilibrium without collusion: when a core auditor’s observability of a specialist’s work is low, declining to understa...

From Orchestration to Integrated Judgment Optimization

Most agent-system research proceeds bottom-up from models, tools, memory, role assignment, and orchestration. This paper develops a complementary boundary-first architecture motivated by the public LimFlex wrapper perspective. Boundary-First Integrated Judgment Optimization (BF-I...

Regime-switching connectedness among European football clubs: a TVP-VAR analysis of volatility states and structural shifts

Purpose This study aims to investigate the dynamic interconnectedness among major publicly listed European football clubs, focusing on how return shocks propagate across club equities and whether these spillovers vary across volatility regimes. Design/methodology/approach Using d...

The Inevitable Beginning: A ∆-Framework for Reading Purpose into the Big Bang

AbstractThe Big Bang Event was not an accident. 13.8 billion years before the emergenceof humans, the Event established the physical and temporal conditions necessaryfor intelligent life. This paper proposes a Generic Thinking Unit (GTU) frameworkbased on the principle ∆ : 0 → 1,...

Spectral Endomorphism Factorization and Exceptional Degree-Two Root Correspondences in Codimension-Three Lefschetz Failure

Let $X$ be a smooth rational surface obtained by resolving the generically reduced quadratic-root correspondence attached to a controlled codimension-three weak Lefschetz failure. The preceding Pfaffian analysis produces a pulled-back rank-two quotient bundle $Q$, a nowhere-zero...

Characteristic central nervous system fingerprints and related molecular signatures in difficult-to-treat rheumatoid arthritis

Abstract Background Despite guideline-recommended treatment, approximately 30% of rheumatoid arthritis (RA) patients remain symptomatic and are classified as difficult-to-treat (D2T), representing an unmet clinical need. D2T RA is a heterogeneous state potentially involving diffe...

Analysis of the evolution of South-South Cooperation from the perspective of Southern Identity

Abstract We propose the term “Southern Identity” to encompass the concepts of the Third World, developing countries and the Global South, establishing a logical counterpart to Western Identity. The concepts of the Third World, developing countries and the Global South arose withi...

Canonical Chain–Node Encoding and Finite-Width Return Renormalization for the Accelerated Collatz Map

We select a canonical orientation of an alternating signed-binary representation of positive odd integers and refine it into a chain--node encoding, called the canonical CPE. The signed representation itself is classical in spirit and closely matches the alternating binary system...

CosmosBeating • Cosmic Geometry and Topology — Paper I: The Primordial Tone

Holographic Information Ontological Framework • CosmosBeating • Cosmic Geometry and Topology (HIOF•CGnT) A Ten-Paper Series on Distinction as the Ontological Foundation of Physics This series presents the Holographic Information Ontological Framework (HIOF), developed together wi...

Hidden diversity in Early Palaeozoic parasites: new indication from Orsten-type Ordovician pentastomidans (tongue-worms)

Abstract Orsten-type Lagerstätten sensu stricto are represented by several localities around the world, delivering a unique window into the meiofauna of the Early Palaeozoic. They are providing beautifully three-dimensionally preserved, phosphatized organisms, mostly articulated...

Quantifying Patellofemoral Instability in a Sea of Metrics

Patellofemoral instability is a spectrum of disorders in which the patella loses normal tracking within the trochlear groove, presenting as subluxation or dislocation. Accurate quantification is essential for guiding treatment, yet no unified clinical and imaging scoring system e...

The potential therapeutic effect of quercetin on mitochondrial dysfunction in hepatorenal toxicity induced by aluminum chloride in an experimental rat model

Aluminum is a xenobiotic element known to induce hepatorenal toxicity through mechanisms involving mitochondrial dysfunction, oxidative stress, and inflammation. Quercetin, a dietary flavonoid with potent antioxidant and anti-inflammatory properties, has shown promise as a therap...

The value of a name – an ex-ante rethink of fund naming strategies considering the ESMA guidelines

Purpose This study aims to evaluate ESMA guidelines as a policy solution to align fund naming strategies with actual practices. It addresses the sustainable development challenge of greenwashing, which misdirects capital away from genuine environmental and social solutions. Desig...

A Dispersive-field-valued 2-Morphism Framework for FRLT

This short communication introduces a dispersive‑field‑valued 2‑morphism framework for FRLT. By modeling local angular variation and global discrete jumps within a unified dispersive field D=U(1)×Z, FRLT’s generative pivots acquire a coherent 2‑categorical structure capturing loc...