Research works

The KAT8-CDK1 K33 acetylation axis drives doxorubicin resistance by suppressing ferroptosis and apoptosis in breast cancer

Abstract Doxorubicin (Dox) resistance severely limits therapeutic efficacy in breast cancer, yet the epigenetic mechanisms linking cell-cycle control to therapy-induced cell death remain unclear. Here, we identify the histone acetyltransferase KAT8 as a critical driver of Dox res...

Tibial cortex transverse transport accelerates diabetic wound healing via systemic mobilization of non-classical monocytes

Aims: To clarify the immunomodulatory mechanisms by which tibial cortex transverse transport (TTT) accelerates wound healing in a type 2 diabetic rat model, with particular focus on the dynamics of subsets of monocytes and macrophages. Methods: A total of 186 male Sprague-Dawley...

The Möbius–Obstruction Instrument: From Response Surfaces to Irreducible Supports and Minimal Interventions

Exact support recovery, a necessary-and-sufficient noisy-output gate, and a finite physical proof of operation. For one fixed finite parent and a declared subset-response surface, this work defines A_tau(Y)=min{S nonempty: |Delta Y(S)|>tau} and I_tau(Y)=(A_tau(Y), blocker(A_tau(Y...

Community Firearm Violence, Youth Depression, and Suicide Risk in Philadelphia: 2017–2024

OBJECTIVES: Youth suicide and depression rates increased during the COVID-19 pandemic. In Philadelphia, firearm violence surged and has since declined to pre-pandemic levels. We examined whether youth depression and suicide risk also declined and whether community firearm violenc...

Evaluation and application of iron-modified clay adsorbents for clean fuel production in the frame of desulfurization technology

Abstract This study investigated clay adsorbents for benzothiophene sulfone (BTO) removal through oxidative desulfurization. Bentonite-Fe 3+ (BF3), Fe 6+ (BF6), activated clay-Fe 3+ (ACF3), and Fe 6+ (ACF6) were synthesized via impregnation of raw bentonite (BR) and raw activated...

From Orchestration to Integrated Judgment Optimization : A Boundary-First Architecture for Dynamic Teams, Version-Governed Structural Autonomy, and Human-Accountable AI

Most agent-system research proceeds bottom-up from models, tools, memory, role assignment, and orchestration. This paper develops a complementary boundary-first architecture motivated by the public LimFlex wrapper perspective. Boundary-First Integrated Judgment Optimization (BF-I...

Effects of nonlocal interactions on s- and d-wave superconducting correlations in the extended Hubbard model

Abstract We investigate the influence of nonlocal interactions on superconducting correlations within the extended Hubbard model. In addition to the on-site Coulomb interaction and nearest-neighbor hopping, we include next-nearest-neighbor hopping together with several physically...

LPA genetic variation is associated with type 2 diabetes after adjustment for lipoprotein(a) concentration: results of the Aragon Workers’ health study

Abstract Background Epidemiological and Mendelian randomization studies have reported an inverse relationship between lipoprotein(a) [Lp(a)] concentration and type 2 diabetes (T2D), although findings have not been uniform across studies. We hypothesized that genetic variation at...

Intracapsular tonsillectomy in adults with obstructive sleep apnoea and large tonsils

PURPOSE: Conventional (extracapsular) tonsillectomy is a well-established treatment for obstructive sleep apnoea (OSA) in adults with tonsillar hypertrophy. Our objective was to determine whether an intracapsular tonsillectomy (ICTE) with a 90% removal of tonsils could be suffici...

Medial Patellofemoral Ligament Reconstruction: Current Techniques, Outcomes, and Controversies

Recurrent patellofemoral instability is a common and disabling condition, particularly among young, active individuals. The medial patellofemoral ligament (MPFL) is a critical stabilizer of the patella, and its reconstruction has become a widely accepted surgical option following...

Cue-specific sexual avoidance, metacognitive beliefs, and sexual functioning in women with lifelong vaginismus: a cross-sectional case–control study

Abstract Background Avoidance is a key maintaining factor in lifelong vaginismus and may extend beyond penetration attempts to broader sexual cues. Metacognitive beliefs, particularly beliefs about the usefulness of worry and the uncontrollability and danger of thoughts, may shap...

Product-Core Stratification of Large Effective Multiplier Rank in Symmetric Frobenius Algebras

Let $A$ be a $2n$-dimensional commutative symmetric Frobenius algebra over a field $k$, let $U=V^\perp$ with $\dim U=\dim V=n$, let $L\subset A$ contain the unit, and consider the Frobenius trilinear form induced by multiplication on $(L/k1)\times U\times V$. Write $(c,a,b)$ for...

A "Probability Stratification and Staged Clearance" Strategy for HIV Cure ——A Systematic Protocol Based on Functional Separation Editing of Hematopoietic Stem Cells, Active Latent Reservoir Reduction, and Patient Stratification

Abstract:The fundamental barrier to an HIV cure is not a lack of technical methods, but theprobabilistic nature of viral escape. As long as a single latently infected cell capableof utilizing the CXCR4 co-receptor (X4-tropic) remains in the body, any strategy thatonly blocks the...

The use of artificial intelligence (AI) in tourism employment: employees’ perceptions and business strategies

Purpose The study aims to focus on the challenges that artificial intelligence (AI) brings to career decisions among tourism employees, while on the other hand, it focuses on how tourism employees’ AI risk perceptions affect their career decisions. In addition, another aim of the...

Disturbance Evolution in Wake Dynamics: A Structural Bridge Between the Carlo Deduction and Vortex‑Shedding Phenomenology

This bridge paper connects the Carlo Deduction — a general disturbance‑evolution framework — to the established phenomenology of wake physics. It demonstrates that vortex shedding, shear‑layer collapse, vortex formation, Strouhal periodicity, and vortex‑street stabilization follo...

Tazemetostat combined PD-1 inhibitor achieving prolonged survival in primary proximal epithelioid sarcoma: a case report and review of the literature

Abstract Background Epithelioid sarcoma (ES) is a rare mesenchymal tumor categorized into proximal (axial) and classical (distal) types. In general, proximal ES come alone with limited treatment options and poor prognosis. Herein, we present the case of a proximal ES treated with...

Stages and costs of processing donated corneas for transplantation in eye banks: a scoping review

The objective was to map the stages and costs of processing donated corneal tissue for transplantation in Eye Banks. The method followed the JBI Institute Reviewer's Manual, and the PRISMA-ScR guidelines were adopted for reporting, to answer the question: "What are the stages and...

Algorithm for classifying the underlying pathologies in postpartum hemorrhage using bleeding rate, fibrinogen, and fibrin/fibrinogen degradation products: a case series study

Abstract Background Understanding patients’ underlying pathologies is essential for appropriate treatment during postpartum hemorrhage (PPH) management. The objective of this study is to develop an algorithm that quantitatively classifies the underlying pathologies in PPH using c...

Escaping the Plantationocene: plotting the future of education

Purpose This article critically analyses the ways in which contemporary international educational development perpetuates plantation systems. It proposes ways to plot an escape from the plantation's extractive education monoculture and move towards multi-epistemological flourishi...

A hierarchical whole-body control framework for humanoid robots in shelf-picking

Purpose This paper aims to present a hierarchical whole-body control (H-WBC) framework for humanoid shelf-picking in structured shelf environments. The objective is to improve motion coordination, posture regulation and safe task execution for humanoid manipulation in spatially c...