Research works

Femoral Rotation Osteotomy in Patellofemoral Instability Surgery

Femoral anteversion is an important anatomic risk factor for patellofemoral instability. History and physical exam, in addition to diagnostic imaging, are all components of a full assessment to determine whether femoral anteversion is a significant contributor to a patient's pate...

An elementary form of agency at planetary-scale

Abstract The claim that climate homeorhesis—non-equilibrium steady-state dynamics that underlie Earth’s long-term habitability—depends on an integrated biosphere–climate system capable of acting on its own is central to debates surrounding the Gaia hypothesis. This paper presents...

Disturbance Evolution in Wake Dynamics: A Structural Bridge Between the Carlo Deduction and Vortex‑Shedding Phenomenology

This bridge paper connects the Carlo Deduction — a general disturbance‑evolution framework — to the established phenomenology of wake physics. It demonstrates that vortex shedding, shear‑layer collapse, vortex formation, Strouhal periodicity, and vortex‑street stabilization follo...

Neddylation of NFATc1 and Runx2 regulates osteoclast–osteoblast balance and represents a dual-action therapeutic target for postmenopausal osteoporosis

Postmenopausal osteoporosis (PMOP) arises from a bone remodeling imbalance in which osteoclast-mediated resorption exceeds osteoblast-driven formation. However, current therapies primarily target osteoclasts without restoring osteoblast function, underscoring the need for mechani...

Ultra-high-performance liquid chromatography-quadrupole-orbitrap-tandem mass spectrometry identifies 24 “unexpected” compounds to construct a one-for-one anti -counterfeiting quality markers system of Lianhua Qingwen capsule

Abstract The study completed the quantification of 110 compounds from Lianhua Qingwen ( LHQW ) capsule using library-aided ultra-high-performance liquid chromatography-quadrupole-orbitrap-tandem mass spectrometry under three adducting models ([M − H] - , [M + HCOO] - , and [M + H...

Impact of magnification and fluorescence guidance on conservative retrieval of failed fiber posts: an in vitro study

Abstract Background Fiber post removal during endodontic retreatment is challenging since fiber posts bond strongly to root dentin, closely matching its color, making the post–cement–dentin interface difficult to distinguish. Consequently, fiber post retrieval may cause unnecessa...

Management, demographic and dietary insights from 7 years of aerial shooting of feral pigs in an agricultural landscape

Context Feral pigs are one of the most destructive invasive vertebrate species in Australia. Aerial shooting is considered one of the most effective methods for causing a rapid reduction in feral pig density at a landscape scale. Aims We aimed to assess the effects of 7 years of...

Exercise and Sport Participation in Pediatric Hypertrophic Cardiomyopathy: A Changing Paradigm

Abstract Purpose of Review This review aims to detail recent research and guidelines that have changed the approach to exercise and sport participation in the pediatric hypertrophic cardiomyopathy (HCM) population. Recent Findings Recent studies, including the landmark LIVE-HCM c...

Methylation-sensitive restriction endonuclease-based amplification assay for detecting DNA methylation in colorectal cancer: a cross-sectional study

Abstract Background This study evaluates the clinical utility of combined SDC2 and ADHFE1 methylation analysis for colorectal cancer (CRC) detection using a methylation-sensitive restriction endonuclease (MSRE)-based assay. Methods Leveraging the specificity of MSRE, we developed...

A RELATIONAL RESPONSE TO THE HARD PROBLEM OF CONSCIOUSNESS:

This paper introduces the Relational Principle of Emergence as a disruptive solution to David Chalmers' "hard problem" of consciousness. It argues that traditional philosophical approaches (functionalism, dualism, panpsychism, eliminativism, and IIT) have failed due to the errone...

A Generative Reconstruction of Geometric Frustration as a Non‑Coherent Stable Structure of Low Consistency

This paper reconstructs geometric frustration as a generative, non‑coherent stable structure. By linking FRLT pivots, groupoid morphisms, signed‑graph holonomy, and Minkowski causality, it shows that low‑order states arise from proliferating non‑closure that stabilizes as a unifi...

Quadratic Apolar Residues and Pfaffian Root Correspondences in Codimension-Three Lefschetz Failure

Let $\kk$ be an algebraically closed field of characteristic zero, let $S=\Sym(V)$ with $\dim V=3$, and let $A=S/\Ann(F)$ be a compressed standard-graded Artinian Gorenstein algebra of socle degree $2m+1$, where $m\ge2$. We study a corank-one failure of multiplication by a genera...

Canonical Chain–Node Encoding and Finite-Width Return Renormalization for the Accelerated Collatz Map

We select a canonical orientation of an alternating signed-binary representation of positive odd integers and refine it into a chain--node encoding, called the canonical CPE. The signed representation itself is classical in spirit and closely matches the alternating binary system...

Early Effects of Communities That Care on System Transformation: a Non-randomized Community Trial in Germany

Community coalition approaches such as Communities That Care (CTC) are regarded as key strategies for translating prevention science into community-level improvements in youth outcomes. It was shown that CTC improves three system transformation outcomes. The present study aimed t...

Degeneracy of the Garriga–Mukhanov Perturbation Variables at Time-Symmetric Surfaces

This preprint identifies a domain-of-validity failure in the Garriga-Mukhanov perturbation variables for curved cosmological models at time-symmetric surfaces, where the Hubble rate and background field velocity both vanish.It derives a universal inverse-square divergence in the...

Zulfiability as a Structural Origin of Generalized Function Classes

AbstractThis paper introduces Zulfiability as a structural origin arising from a prim-itive transformation mapping Z(x, u), rather than as a generalization of convexlike functions. The central object is a mapping that governs admissible structuraltransitions between points. Under...

Impact of denosumab therapy on periapical healing following root canal treatment: a 10-year retrospective case-control study

Abstract Introduction Denosumab is a potent RANKL inhibitor used for osteoporosis, yet its impact on root canal treatment (RCT) outcomes remains less understood compared to bisphosphonates. This study evaluated the periapical healing outcomes of RCT in patients receiving denosuma...

ANALGESIC ACTIVITY OF A NATURALLY OBTAINED HERBAL COMPOUND IN A RAT MODEL

Pain is one of the most common clinical complaints, and its management remains a challenge due to the limitations of conventional analgesics. Non-steroidal anti-inflammatory drugs (NSAIDs) and opioids, though effective, are associated with adverse effects such as gastrointestinal...

The Inevitable Beginning: A ∆-Framework for Reading Purpose into the Big Bang

AbstractThe Big Bang Event was not an accident. 13.8 billion years before the emergenceof humans, the Event established the physical and temporal conditions necessaryfor intelligent life. This paper proposes a Generic Thinking Unit (GTU) frameworkbased on the principle ∆ : 0 → 1,...

Fiberoptic endoscopic evaluation of swallowing in neurogenic oropharyngeal dysphagia in adults: Part 2 of a scoping review

PURPOSE: The main objective of this scoping review was to describe the qualitative and quantitative parameters of fiberoptic endoscopic evaluation of swallowing (FEES) protocols, including their operational definitions and scales used in adults with neurogenic oropharyngeal dysph...