Research works

Untargeted 1H-NMR metabolomics of bronchoalveolar lavage fluids to identify biomarkers for early diagnosis of lower respiratory tract infections

Lower respiratory tract infections (LRTIs) remain a leading cause of death worldwide. Their complex clinical presentation underscores the need for accurate, timely laboratory diagnosis; however, reliable diagnostic biomarkers are still lacking. We performed untargeted 1 H-NMR met...

Experimental modal-based damage evaluation of masonry cross-vaults under quasi-static and dynamic cyclic loading

Masonry cross-vaults are double-curvature structural systems widely employed in historic churches and monumental buildings, which exhibit a pronounced vulnerability to seismic actions owing to the mechanical characteristics of their constituent materials. In such structures, diag...

Disturbance-observer-based adaptive neuro-fuzzy sliding mode control for collaborative ASV and URV systems

This paper proposes a disturbance-observer-based adaptive neuro-fuzzy sliding mode control (DO-ANFSMC) framework for collaborative autonomous surface vehicle (ASV) and underwater robotic vehicle (URV) systems operating in search-and-rescue missions under environmental disturbance...

Pain characteristics and risk of scale-identified cognitive impairment among middle-aged and older Chinese adults: a longitudinal study from CHARLS

Cognitive impairment and chronic pain have become major public health challenges, adversely affecting the lives of middle-aged and older adults. However, longitudinal evidence on pain characteristics and subsequent cognitive outcomes in Chinese populations remains limited. We exa...

10.6 μm laser moxibustion can improve oxidative stress and abnormal energy metabolism in liver of hypothyroidism rats through Nrf2/HO-1 and Nrf2/PGC-1α/TFAM pathways

Hypothyroidism (HypoT) is a systemic hypometabolic disorder characterized by thyroid hormone deficiency and is closely associated with oxidative stress (OS). The hypothalamic-pituitary-thyroid (HPT) axis plays a key role in regulating thyroid hormone secretion and the Nrf2 signal...

Data-driven identification of modifiable risk factors for colorectal cancer in Palestine using machine learning methods

Colorectal cancer (CRC) is a growing public health concern in Palestine, yet limited evidence is available on locally relevant behavioral, dietary, socioeconomic, and contextual predictors. Machine learning (ML) may support prevention-oriented risk stratification by identifying c...

Impact of adjuvant endocrine therapy on disease-free survival in early triple-positive breast cancer: a multicenter retrospective cohort study of the Turkish oncology group

Triple-positive breast cancer (TPBC), characterized by concurrent ER, PR, and HER2 positivity, poses unique therapeutic challenges due to ER–HER2 crosstalk. The optimal adjuvant endocrine therapy in TPBC patients receiving anti-HER2 regimens remains poorly defined. This multicent...

Quality of postoperative recovery in patients undergoing laparoscopic colorectal cancer resection as affected by transversus abdominis plane block combined with moderate neuromuscular blockade: a randomized controlled trial

Postoperative recovery quality in laparoscopic surgery may benefit from deep neuromuscular blockade, whereas the effects of combining transversus abdominis plane block (TAPB) with moderate neuromuscular blockade in this regard remain unreported. This work investigated whether mod...

Emerging Trends in the Incidence (1999–2022) and Mortality (1999–2023) of Thyroid Cancer in the United States: CDC WONDER Database Study

Background: Thyroid cancer (TC) is a common endocrine malignancy with a rising global incidence. This study examined trends in TC incidence and mortality in the United States over the past two decades. Methods: TC mortality data from 1999-2023 and incidence data from 1999-2022 we...

Optimization-driven feature learning for long-tailed object detection in optical remote sensing imagery

With the rapid advancement of remote sensing technologies, deep learning–based object detection has been widely adopted for large-scale optical remote sensing imagery. Despite the remarkable progress achieved by convolutional and transformer-based detectors, their performance rem...

Application of multi-technique integration in the prenatal diagnosis of mosaicism derived from an ICSI blastocyst: a diagnostic approach and clinical implications

To investigate the prenatal diagnosis following intracytoplasmic sperm injection (ICSI) and blastocyst transfer. By integrating multiple cytogenetic and molecular techniques, we characterized a mosaic duplication of chromosome 20p, evaluated its pathogenicity and clinical signifi...

Cancer drug response and resistance: molecular mechanisms and combating strategies

Despite remarkable advances in cancer drug treatment, including chemotherapy, targeted therapy, and immunotherapy, therapeutic resistance remains a formidable clinical barrier, limiting durable responses and long-term survival. Drug resistance can be broadly categorized as intrin...

Tranexamic acid in primary total knee arthroplasty: a systematic review and meta-analysis of blood loss, transfusion, and deep vein thrombosis

Tranexamic acid (TXA) has been widely used in primary total knee arthroplasty (TKA) to reduce perioperative blood loss, but the pooled evidence regarding blood loss, transfusion, and deep vein thrombosis (DVT) remains to be further clarified. The purpose of this meta-analysis was...

Mapping reproductive healthcare needs of incarcerated women: a scoping review

The increasing female prisoner population worldwide highlights the urgent need for tailored reproductive healthcare services in correctional facilities. However, there remains a significant gap in comprehensively understanding and addressing the unique reproductive healthcare nee...

Progress, challenges, and future directions of pancreatic cancer surveillance in high-risk populations

Pancreatic cancer remains one of the most lethal malignancies because most patients are diagnosed with advanced disease, when curative treatment is rarely possible. Population-wide screening is not currently recommended because pancreatic cancer remains relatively uncommon. Early...

Central role of vapBC toxin–antitoxin system expression in the pathogenicity and antimicrobial resistance of Shigella sonnei isolates from pediatric diarrheal patients

Shigella sonnei , a Gram-negative bacterium, has been identified as a primary causative agent of gastrointestinal disease in humans. Antibiotic resistance has emerged as a critical concern in the context of Shigella species, thereby complicating the effective treatment of shigell...

Trends and fluctuations in technical performance in the 2010–2022 FIBA women’s basketball world cup

This study selected the quarterfinals, semifinals, and finals of the FIBA Women’s Basketball World Cup in 2010, 2014, 2018, and 2022, totaling 32 games, and aimed to examine the trends, fluctuations, and differences in technical performances of the Women’s Basketball World Cup fr...

Surgical strategies for external auditory canal cholesteatoma based on the He staging system: a retrospective study

PURPOSE: To investigate individualized surgical treatment strategies and clinical management experience for external auditory canal cholesteatoma (EACC) based on the He staging system. METHODS: Clinical data from 59 patients (61 ears) with EACC who underwent surgical treatment at...

A cilia-associated epithelial alteration axis nominates ERICH3 as an entry point to PI3K engagement in lung adenocarcinoma

LUAD adopts heterogeneous oncogenic signalling states, and bias toward a PI3K–AKT–mTOR–engaged state is not fully explained by canonical pathway lesions. Because membrane-proximal spatial organization can tune receptor-proximal signalling yet is difficult to quantify in human tum...

Associations of key diet-quality indexes with trajectory of multimorbidity: a prospective study in the UK Biobank

Dietary patterns have been associated with the morbidity and mortality of individual non-communicable diseases(NCDs). However, the impacts of baseline dietary patterns among the initially healthy population on the progression from healthy to first non-communicable disease (FNCD),...