Research works
The research papers we track — the newest first. Works with a plain-language summary link to it.
126741 work(s)
- BiologyOpen access
TEExplorer: a web portal to investigate TE-epigenome associations across human cell types
Approximately half of the human genome is derived from transposable elements (TEs) and several studies support the involvement of TEs in genome regulation in development, immunity and disease. We previously leveraged 4614 ChIP-seq samples from the International Human Epigenome Co...
- Materials & Energy
FullMS2Former:A Transformer Model for Near-CompletePrediction of Peptide Tandem Mass Spectra
Abstract Accurate prediction of peptide tandem mass spectra is essential for confident peptide identification. Existing deep learning models achieve high similarity to experimental spectra but remain constrained by fixed fragment dictionaries of common fragment ions, limiting the...
- Society & EconomicsOpen access
SOURCE: journal LINE: Jul 26 17:41:29 vmi3382514 python3[961]: psycopg2.OperationalError: connection to server at "127.0.0.1", port 5432 failed: Connection refused CONTEXT: Jul 26 17:41:29 vmi3382514 python3[961]: conn = _connect(dsn, connection_factory=connection_factory, **kwas...
- Physics & SpaceOpen access
We study a closed framed space curve with centreline r(a) = (sin 2a, cos a, sin a) and a periodically driven transverse tube Hamiltonian. The curve exhibits a clean spinorial 4π frame lift, but the corresponding central holonomy does not by itself select a unique two-dimensional...
- Health & MedicineOpen access
Epstein-Barr virus (EBV)-associated gastric cancer (EBVaGC) is a distinct subtype of gastric cancer (GC) with characteristic clinicopathological and molecular features. EBVaGC exhibits a more extensive lymphocyte infiltration than EBV-negative counterparts, and expresses a range...
- BiologyOpen access
The Biodiversity Farmers: 6 Ways Ancient India Fed a Civilisation Without Destroying the Land
Long before "sustainable agriculture" became a policy phrase, ancient India was already running one of the most biodiverse farming systems the world has documented. This article traces that system from its genetic roots to its near-collapse and its ongoing recovery. It opens with...
- Health & MedicineOpen access
Lupus nephritis requires long-term immunosuppressive therapy, which is often associated with severe systemic side effects. Therefore, new therapeutic strategies that maintain high efficacy while minimizing adverse effects is essential. Although nanomedicine has advanced systemic...
- BiologyOpen access
ABSTRACT Cadherin 1 ( CDH1 ) encodes E‐cadherin, a key epithelial adhesion molecule traditionally associated with tumor suppression and epithelial–mesenchymal transition (EMT). However, its roles across cancers remain incompletely understood, particularly within multilayer regula...
- BiologyOpen access
Background: To investigate whether the accuracy of initial hearing aid amplification verified by real ear measurement (REM) predicts long-term fitting outcomes after one year, and to identify frequency-specific predictors associated with sustained fitting precision. Methods: This...
- Society & Economics
The accelerated integration of robotics within the manufacturing sector has facilitated enhanced work efficiency and reduced resource consumption among employees. How will employees utilize these resources saved by robots? Will they reinvest these resources into the organization...
- Materials & Energy
Host Dearomatization for Prolonging Room‐Temperature Phosphorescence
ABSTRACT Host–guest doping has emerged as a powerful platform for constructing organic room‐temperature phosphorescence (RTP) materials, owing to its structural tunability and facile fabrication. However, molecular design has largely focused on guest molecules, while host screeni...
- AI & Computing
Light‐Cone Shell Queries for Scalable Time‐Gated Rendering
Abstract Monte Carlo time‐gated rendering requires sampling light paths that not only connect a sensor to an emitter, but which also have a total travel time that falls within a narrow interval, a constraint that is difficult to importance sample. We show that this problem has an...
- Society & Economics
Purpose This paper investigates how AI-enabled dynamic pricing affects revenue, profitability and competitive dynamics in licenced sport merchandise retail. Although dynamic pricing is well studied in sport ticketing, its AI-enabled extension to licenced merchandise remains large...
- AI & ComputingOpen access
Helical Holographic Quantum Mechanics (H3QM): A Unified Theory of Geometric Physics
Modern physics has long relied on a fragmented Standard Model with hardcoded fields to explain isolated phenomena. Harmonic 3D Quantum Manifold (H3QM) introduces a fundamental geometric unification: the Universe operates on a single topological tension medium governed by 3D manif...
- Society & EconomicsOpen access
Legal legitimacy is often understood as a collective basis for rule-following: people accept legal authority because they recognise it as acting in the name of a political community to which they belong. We develop an exploratory account of what happens when the institution most...
- Materials & EnergyOpen access
What is happening at the atomic level during the seed-mediated growth of copper on gold?
Bimetallic nanocrystals obtained via seed-mediated growth are typically analyzed using conventional electron microscopy and many interesting features at the atomic level are often missed. Here we report the seed-mediated growth of copper (Cu) on gold (Au) nanospheres for the synt...
- BiologyOpen access
Toward Personalized Regenerative Therapies for Parkinson's Disease
Parkinson's disease (PD) represents one of the most common neurodegenerative disorders, significantly impacting the quality of life of millions of people worldwide, and posing growing challenges for healthcare systems. Driven by demographic shifts and increasing numbers of patien...
- Health & MedicineOpen access
Huperzine A (HupA) is a natural Lycopodium alkaloid known for its potent neuroprotective properties through the inhibition of acetylcholinesterase. Nevertheless, the limited understanding of its biosynthesis restricts its broader application. This study integrates full-length and...
- Engineering & TechnologyOpen access
As piston rods for excavator boom hydraulic cylinders shift from integral forging to welded assemblies of separately manufactured rod bodies and rod heads, joint reliability becomes critical to load-bearing performance. In this study, 60 mm diameter quenched-and-tempered/as-rolle...
- Biology
Nitro Reduction‐Based RNA Control and Ultrafast Release
ABSTRACT RNA protection and controlled release are critical for both fundamental research and therapeutic applications, yet the development of simple, efficient, and reversible post‐synthetic RNA modification strategies remains a significant challenge. Here, we introduce a straig...