Research works

Task-specific determinants of one-year performance after unilateral primary total knee arthroplasty

Aims This study aimed to investigate the associations between performance-based outcomes (walking, sit-to-stand, and stair climbing) and impairment-level measures one year after primary unilateral total knee arthroplasty (TKA) using an analytic framework that mitigates multicolli...

Extended forming depth and thickness uniformity of metallic bipolar plate under variable magnetic field path in magnetorheological elastomer assisted forming

Abstract During the flexible-die forming of metallic bipolar plates, metal flow is generally constrained by the progressively increased frictional resistance at the die cavity edges, resulting in the limited formability. Accordingly, in this study, a forming method using magnetor...

Demystifying the Black Box: Overcoming AI Intimidation by Building the Engine

The rapid acceleration of Artificial Intelligence has created a paradigm where the majority of the world interacts with AI purely as consumers - prompting opaque, cloud-hosted "black boxes." This paper explores a pedagogical approach to AI education that pivots the learner from a...

A bone histological approach to distinguish periprosthetic joint infection from aseptic osteolysis in revision joint replacement

Aims Accurate differentiation between periprosthetic joint infection (PJI) and aseptic osteolysis (AO) remains a major clinical challenge in revision joint arthroplasty. We examined bone biopsies for alterations in bone matrix integrity and the osteocyte lacunocanalicular network...

The Indus Script: A Structural Phonetic Framework for Decipherment via the 'Parmanu' (Phonetic Atom) Theory

The decipherment of the Indus Valley Script (c. 3300–1900 BCE) has long been stalled by "meaning-hunting"—the erroneous attempt to map signs directly to whole words of specific language families (e.g., Dravidian or Indo-Aryan). This paper introduces a paradigm shift via the 'Parm...

Drug safety in patients with mitochondrial disease: an observational cohort study

Abstract Background Mitochondrial diseases are common inherited neurometabolic disorders and frequently involve the nervous system, yet their multisystem nature often necessitates complex pharmacological management. Many commonly prescribed medications have off-target effects on...

10,000 种植物基因组计划

陆生植物共有38万余种，2.67万属，约667科，主要来自非开花植物（苔藓、地草、金鱼草、单生植物/蕨类植物、石松属、裸子植物等）和开花植物（木兰科）、基生被子植物（ANA 级）、单子叶植物/草、asterids 和 rosid 等）。10KP项目旨在对代表植物的每个主要进化枝的 10,000 多个基因组进行测序。根据大...

Physiological anthropology and human biology: overlapping interests, differing approaches

Abstract This brief review describes multiple overlapping research interests within the fields of human biology and physiological anthropology, for example, human physiological responsiveness to environmental stressors, e.g., heat, cold, hypoxia, constructed environments, and wor...

Analysis and Implementation of Minimum-Redundancy Huffman Codes

This student research project analyzes David A. Huffman's 1952 paper, "A Method for the Construction of Minimum-Redundancy Codes." The document explains the theory of minimum-redundancy prefix-free codes, formulates the greedy merging property behind Huffman coding, and designs b...

Generalized Holographic Principle (GHP): Universal Law of Projective Reality

This article presents the Generalized Holographic Principle (GHP) as a universal law of projective reality that underlies the entire ontological vertical. GHP generalizes the classical holographic principle ('t Hooft, Susskind), which was limited to black holes and quantum gravit...

Short-chain fatty acid enrichment, TLR4/MyD88/p-JNK inhibition, and gut metabolic modulation: a triple mechanism by which the probiotic ameliorates colorectal cancer

Abstract Chronic intestinal inflammation is a major risk factor for colorectal cancer (CRC). This study investigated the therapeutic potential of the probiotic Streptococcus thermophilus NCU074001 (ST) in a mouse model of colitis-associated CRC. ST supplementation reduced tumor n...

The TaPUB1-TabZIP9L-TaLEA3Module Positively RegulatesDrought Tolerance by Mediating Stomatal Closure and Antioxidant Abilityin Wheat

Abstract Wheat yield is increasingly constrained by drought stress. Post-translational modifications, particularly ubiquitination, are essential for plant adaptation to abiotic stresses. This study demonstrates that TaPUB1 overexpression substantially enhances drought tolerance,...

Open-Set Semiconductor Defect Classification in SEM Images via Uncertainty-Aware Local Prototype Alignment

Automated classification of scanning electron microscope (SEM) defects is complicated by acquisition-domain shift, long-tailed classes, and target-only defect types that invalidate the closed-set assumption. We propose an offline open-set adaptation framework that combines a thre...

Prolonged screen time is associated with increased prevalence of sleep disorders in children

Abstract Purpose This study aimed to investigate whether sleep disorders are associated with electronic screen use before bedtime and total daily usage time in preschool children. Methods A cross-sectional study was conducted with 604 preschool children aged 4–5 years. Sleep diso...

Analysis and Implementation of Minimum-Redundancy Huffman Codes

This student research project analyzes David A. Huffman's 1952 paper, "A Method for the Construction of Minimum-Redundancy Codes." The document explains the theory of minimum-redundancy prefix-free codes, formulates the greedy merging property behind Huffman coding, and designs b...

Attenuation of hydroclimatic influence on groundwater dynamics under anthropogenic stress: A decadal spatiotemporal analysis in Jaipur, India

Abstract Groundwater constitutes the primary freshwater resource in semi-arid regions, where low and erratic rainfall combined with high evapotranspiration limit effective recharge. Jaipur, a rapidly expanding metropolitan city in western India, is experiencing increasing groundw...

Pediatric Outpatient Care After Operation Metro Surge in Minneapolis

BACKGROUND Operation Metro Surge, a joint initiative by the Department of Homeland Security and the United States Immigration and Customs Enforcement (ICE), significantly disrupted daily life in Minnesota. Despite numerous anecdotal reports, the impact and scale of this disruptio...

Uptake of at-home self-collected dried blood spots for HIV, hepatitis C and syphilis screening among Māori gay, bisexual and other men who have sex with men in Aotearoa New Zealand: an observational epidemiological study

Background HIV testing is an integral component of prevention, reducing undiagnosed infection and promoting early treatment. Indigenous gay, bisexual and other men who have sex with men (GBM) are at increased risk of HIV and sexually transmitted infections (STIs), but may experie...

Human thymic Treg-derived extracellular vesicles display a defined proteomic and miRNA signature with donor-variable suppressive activity

Abstract Background Extracellular vesicles (EVs) are key mediators of intercellular communication that transfer functional molecules reflective of their parent cells and are increasingly explored as cell-free therapeutic agents. Immunoregulatory cell types, including regulatory T...

NEL1: Claim-Gated Tree-Ring Forecasting under Source Shift and Operational Constraints

NEL1 presents a nine-stage technical whitepaper and numerical evidence ledger for one-step tree-ring width forecasting under temporal dependence, source shift, uncertainty, and operational constraints. The study uses two public NOAA/WDS Paleoclimatology collections from Kaindy La...