Research works

High 28-day mortality in resistant gram-negative bloodstream infections in the ICU: retrospective cohort study

Hospital-acquired bloodstream infections (BSI) caused by carbapenem-resistant and difficult-to-treat resistant (DTR) Gram-negative bacteria are a global threat associated with high mortality in (ICUs). The aim of this study was to evaluate 28-day mortality, independent risk facto...

SNP genotyping in Pseudotsuga menziesii and Pinus radiata using targeted genotyping-by-sequencing (GBS): improved Bayesian SNP calling using a beta-binomial distribution and other optimized input parameters

Single-nucleotide polymorphism markers (SNPs) have important applications in gene conservation, breeding, and fundamental genetics research. Our long-term goal is to develop routine approaches for SNP genotyping in forest trees. Ideally, these approaches would be inexpensive, abl...

Protective Effect of Ozone on Liver Ischemia–Reperfusion (I/R) Injury in Streptozotocin-Induced Diabetic Rats

The aim of this study was to investigate the effects of ozone therapy on the liver, one of the organs most affected by ischemia–reperfusion damage in people with diabetes. Thirty male Wistar albino rats were used in this study. The rats were randomly divided into four groups: the...

Impact of carotenoids on body composition and adipokine hormones: a systematic review and meta-analysis of randomized controlled trials

Carotenoids, a class of antioxidant phytochemicals, have been proposed to influence adiposity and metabolic regulation through modulation of oxidative stress, inflammation, and adipokine secretion. However, clinical evidence remains inconsistent. This systematic review and meta-a...

Randomized phase 2 trial of a PARP inhibitor TSL-1502 in germline BRCA-mutated, HER2-negative locally advanced/metastatic breast cancer

Glucuronide prodrug strategies may enhance target specificity and reduce the toxicity of PARP inhibitors, but no clinical evaluation has been performed. We evaluated TSL-1502, a novel glucuronide prodrug of a PARP inhibitor, in a randomized, open-label, phase 2 study at 28 sites...

Integrated Pharmacokinetic Assessment and Individualized Dosing in Pediatric Critical Care

Optimizing pharmacotherapy in pediatric intensive care requires an integrated understanding of developmental physiology and critical illness-related pathophysiology. Drug exposure in children cannot be interpreted as a simple scaled version of adult pharmacokinetics. Critically i...

Machine-Learning Analysis of the Electronic Structure of Atomically Thin MnTe Films from Scanning Tunneling Spectroscopy

Layered two-dimensional (2D) van der Waals magnetic crystals based on 3d transition metals and chalcogenides are typically synthesized by chemical vapor transport, while establishing epitaxial, layer-by-layer growth under vacuum remains essential for device applications. Here, we...

Development of machine learning models for predicting delirium in elderly patients after thoracic surgeries

Postoperative delirium (POD) is a frequent neurological complication following anesthesia and surgery, which is associated with increased comorbidities and mortality. The current study developed and internally validated a machine learning model for predicting POD in elderly patie...

Divided autonomy: fiscal decentralisation across Italian regions and municipalities

This paper shows how granular subnational data reveal asymmetries invisible in national aggregates by constructing indicators of fiscal autonomy, revenue composition and fiscal dependence for Italian regional and municipal governments using the novel OECD’s REGOFI and MUNIFI data...

Comparison of lung ultrasonography and chest radiography in detecting neonatal respiratory distress as a composite clinical condition: a prospective cross-sectional diagnostic accuracy study at Muhimbili National Hospital

Neonatal respiratory distress (RD) is a leading cause of neonatal morbidity and mortality. While chest radiography (CXR) is the traditional modality of diagnosis, lung ultrasound (LUS) has emerged as a bedside, radiation-free alternative for evaluating neonatal respiratory condit...

Impact of Li1.3Al0.3Ti1.7(PO4)3 content and particle size on the electrochemical properties and stability of polymer-based solid electrolytes for lithium batteries

This work addresses the current limitations of standard composite solid electrolyte membranes through a systematic optimization of the LATP Li 1.3 Al 0.3 Ti 1.7 (PO 4 ) 3 wt fraction and rigorous particle size control via selective milling. By precisely integrating these calibrat...

Consumer responses to industrially processed food in hospitality: Is an authenticity crisis looming?

Hospitality establishments increasingly use industrially processed foods that customers assume are prepared from scratch. Although an open secret in the industry, consumer responses to this practice remain unexplored. Drawing on psychological contract theory, we examine whether i...

Jump into New Fields : How to Cultivate the Originality of a Researcher

This article reflects on the author's research career and thoughts, emphasizing the importance of crossing disciplinary boundaries to cultivate originality as a scientist. Drawing on experiences in surface and interface science, thin films, electrochemistry, solid-state ionics, a...

Application of multimodal deep learning in interior design material matching and colour scheme generation

Material-color coordination is a complex issue in interior design, which is typically left to human judgment. Intelligent multimodal systems have been necessitated by the increasing need for personalized and computationally assisted design workflows. This study introduces a hiera...

Spectral-habitat analysis and perfusion fingerprinting on contrast-enhanced ultrasound for characterizing tumor perfusion in breast lesions

To develop a short-time Fourier transform (STFT)-based perfusion fingerprinting method combined with spectral-habitat analysis for characterizing pixel-wise perfusion heterogeneity on contrast-enhanced ultrasound (CEUS) and to evaluate its ability to differentiate benign and mali...

Culturable Leptospira spp. exhibit no detectable spatial or matrix-associated structuring in Estero de Paco, Manila, Philippines

Leptospirosis is a globally important zoonotic disease that remains a major public health concern, particularly in tropical urban environments where flooding, inadequate sanitation, and high population density facilitate transmission. Despite its burden, the ecological and evolut...

Preparing for School Asthma Readiness

Children and youth spend a large part of their days in school, so it is critical that schools are asthma-friendly and prepared for students with asthma. According to the American Lung Association, elements of an “asthma-friendly school” broadly include reducing sources of asthma...

Factors associated with exclusive breastfeeding at 6 weeks postpartum in Southwest China: a cross-sectional study

Breastfeeding is known to be shaped by a complex interplay of socio-demographic, medical, and psychological factors. However, there is a lack of research on the determinants of breastfeeding at 6 weeks postpartum. This study aimed to examine factors associated with exclusive brea...

Comparative Study of Virgin Polyester and Recycled Polyester Fiber Properties for a Feasible Alternative in Textile Applications

Use of recycled product is important as it conserves natural resources and energy, reduces waste and pollution, and helps combat climate change. Now, the textile industry is seeking for sustainable alternatives to virgin polyester, understanding the quality and limitations of rec...

Factors associated with compliance among urban street food vendors with the food safety and standards authority of India (FSSAI) checklist: evidence from multinomial logistic and gamma regression models

Street food is an integral part in India’s culinary landscape, providing affordable and delicious food options to millions. To regulate food quality and ensure public health, the Food Safety and Standards Authority of India (FSSAI) has established guidelines and statutory require...