Research works

The role of urban agriculture in mitigating urban poverty

Urban agriculture is neglected by policy makers, researchers and urban planners in Ethiopia in general and in research area in particular. Moreover, there are controversial ideas concerning its role in household poverty alleviation. In a modest attempt to fill in the research gap...

Autonomous Computational Law with StellarEq and ACRPL Model

** Autonomous Computational Law with StellarEq and ACRPL Model ** To address the systemic vulnerabilities of legacy natural-language governance—specifically its semantic ambiguity, high-latency auditability, and susceptibility to centralization—this paper presents a mathematicall...

Post-translational modifications of integrins: molecular mechanisms and pathological implications

Integrins are cell-surface adhesion receptors that mediate bidirectional signaling governing migration, proliferation, and survival. Emerging evidence reveals that integrin function is finely controlled by an interconnected network of post-translational modifications (PTMs), span...

A Case Study on Integrated Winterization Design of Accommodation Areas for Arctic-Route LNG Carriers

This paper presents a systematic documentation of Winterization design practice applied to the accommodation area of an Arctic-route LNG carrier, based on direct design experience with a 170K CBM LNG ICE2 CLASS vessel(Winterization notation: − 30℃) ordered by Sovcomflot. In compl...

The utility of trehalose and niclosamide in modulating autophagy to inhibit Leishmania major infection in macrophage cells in vitro

Leishmaniasis is classified as a neglected tropical disease that the available anti-leishmanial medications are limited, often accompanied by side effects, high costs, and the necessity for prolonged treatment. Factors such as the diversity of species, drug resistance of the para...

Exploring the molecular pathways of Noncoding RNAs in ovarian cancer: insights into treatment resistance

Ovarian cancer ranks as the third most common gynecological malignancy, yet it has the highest mortality and recurrence rates among all gynecologic cancers. Chemotherapy combined with immunomodulators and targeted agents, including PTX, ADR, PARPi, and platinum-based chemotherape...

Optimal surgical margin and the efficacy of adjuvant radiotherapy in borderline and malignant phyllodes tumors: a multicenter retrospective study

Purpose: Optimal management of borderline and malignant phyllodes tumors (PT) is not well established, especially regarding margin width and the use of adjuvant radiotherapy (RT).This multicenter study aimed to identify prognostic factors and to assess the effectiveness of adjuva...

Strengthening malaria case management in Plateau State through on-the-job mentorship and supervision: evaluating the effects of targeted capacity building on diagnostic accuracy and data quality

Malaria remains a leading cause of morbidity and mortality in Nigeria, where weaknesses in diagnosis, treatment, and data quality persist. This study evaluated the impact of an integrated on-the-job mentorship and supportive supervision (OJMS) model on malaria case management in...

CT-based three-dimensional virtual reduction with implant templating for tibial plateau fractures involving the posterolateral region: a retrospective cohort study of early postoperative CT reduction quality

Tibial plateau fractures involving the posterolateral region remain technically challenging because of their deep location, limited surgical exposure, and surrounding anatomical constraints. This study investigated whether CT-based three-dimensional virtual reduction with implant...

Inhibition of miR-106a/b Modulates Autophagy-Related Gene Expression in the ULK1–Beclin-1–ATG12 Axis in Experimental Colitis

This study investigated the role of miR-106a and miR-106b in autophagy in a dextran sulfate sodium (DSS)-induced colitis model. DSS induced experimental colitis in Wistar rats, divided into control, DSS-induced-colitis, DSS + AntimiR-106a, DSS + AntimiR-106b, and DSS + scrambled...

A lifespan perspective on stress and happiness: a qualitative metaphor analysis of young and older adults

This study examines the metaphorical perceptions of ‘stress’ and ‘happiness’ among older and younger individuals. The sample consisted of 367 participants (185 young adults and 182 older adults). Data were collected through a structured form including sociodemographic questions a...

Evaluation of Cavitation and Noise Performance of Composite Propellers for Underwater Vehicles using a Large Cavitation Tunnel

Unlike conventional metallic propellers, composite propellers for underwater vehicles exhibit hydroelastic deformation under operating loads and therefore require evaluation methods that account for both hydrodynamic loading and structural deformation. In this study, model tests...

Pharmacist–Physician Task Sharing for Anti-MRSA TDM Orders in a Cancer Center: A Retrospective Before-and-After Study

In August 2025, we implemented physician-pharmacist task sharing for therapeutic drug monitoring (TDM) of anti-methicillin-resistant Staphylococcus aureus agents. Before implementation, physicians entered initial and follow-up TDM orders after pharmacist feedback, but afterward,...

Akkermansia muciniphila attenuates Brucella infection: TLR4−associated inflammatory regulation and gut microbiota remodeling

Akkermansia muciniphila ( A. muciniphila ) is a promising next-generation probiotic with well-established beneficial effects on metabolic disorders, inflammatory diseases, and host immunity. However, whether A. muciniphila protects against Brucella infection remains unknown. Here...

Scale-Dependent Dimensional Trapping: A Topologically Invariant Unified Framework for Galactic Dynamics, Quantum Leakage, and Cosmological Observables

We present Scale-Dependent Dimensional Trapping, a scale-invariant geometric framework that unifies galactic dynamics, quantum gravity attenuation, and cosmological observables without requiring non-baryonic dark matter, dark energy constants, or fine-tuned parameters. By establi...

A Case of Prophylactic Innominate Artery Transection Followed by Laryngotracheal Separation for Tracheal Stenosis Caused by Innominate Artery Compression and Severe Dysphagia

気管切開術後の合併症の中でも重篤かつ致命的なものとして気管腕頭動脈瘻が知られている。気管腕頭動脈瘻を確実に回避する方法として予防的腕頭動脈離断術があるが，明確な適応基準は確立されていない。今回われわれは腕頭動脈による気管狭窄および重度嚥下障害に対して予防的腕頭動脈離断術後に喉頭気...

Effectiveness and Challenges of Protocol-Based Pharmacotherapy Management for Postpartum Rubella Vaccination During the COVID-19 Pandemic

Rubella vaccination is recommended postpartum for women with low rubella antibody titers to prevent congenital rubella syndrome. At our hospital, we have introduced protocol-based pharmacotherapy management (PBPM) for postpartum rubella vaccination, with pharmacists actively invo...

High-intensity circuit training as a potential modulator of serum PFAS levels in women

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants with potential physiological effects. Their accumulation in the body is well documented; however, the impact of high-intensity circuit training (HICT) on serum PFAS levels remains poorly understo...

Modulatory effects of branched-chain amino acid supplementation on neuroendocrine disturbances following traumatic brain injury in rats

Traumatic brain injury (TBI) is frequently accompanied by neuroendocrine disturbances involving the hypothalamic–pituitary–thyroid (HPT) axis and vitamin D–calcium–phosphorus homeostasis. Despite increasing interest in nutritional strategies after TBI, the effects of branched-cha...

Beyond the “Benign” Label: Toward Phenotype-Specific Risk Stratification in Apical Hypertrophic Cardiomyopathy

Apical hypertrophic cardiomyopathy (HCM) was first described nearly 5 decades ago by Yamaguchi and colleagues 1) in a Japanese cohort, characterized by giant T-wave inversion and the now-iconic "ace-of-spades" left ventricular morphology, and reported at the time with strikingly...