Research works

The endothelial activation and stress index (EASIX) as a prognostic predictor in aggressive B-cell lymphoma

Aggressive B-cell lymphoma is the most common subtype of non-Hodgkin lymphoma, with a generally poor prognosis. This study aimed to evaluate the prognostic value of the endothelial activation and stress index (EASIX) score in patients with newly diagnosed aggressive B-cell lympho...

Exploring the hydrogen abstraction pathway in HOM formation from α -pinene photooxidation systems under varying NO conditions

Abstract. Highly oxygenated organic molecules (HOM) are formed via autoxidation during ⚫OH-initiated oxidation of α-pinene. We investigated the relative contributions of OH-addition and hydrogen (H)-abstraction to HOM formation from α-pinene photooxidation under varying nitrogen...

Isocitrate dehydrogenase (IDH) as target for anticancer therapy in brain and gastrointestinal cancers

Isocitrate dehydrogenase (IDH) enzyme system plays a central role in cellular metabolism, growth, and differentiation, and its mutations are associated with alterations of the cell cycle and production of oncometabolites, promoting tumor development. In this narrative review, we...

Ultrasound‐Driven Interfacial Electron Modulation Reprograms Mitochondrial Metabolism for Glioblastoma Therapy

Glioblastoma (GBM) remains difficult to treat because the restrictive blood-brain barrier (BBB), the hypoxic tumor microenvironments, and mitochondrial electron transport chain (ETC)-driven metabolic adaptability jointly limit therapeutic delivery and efficacy. Selective disrupti...

Long-Term Weight Variability Is Associated with Higher Triglyceride Concentrations After Accounting for Long-Term Weight Slope

Background: Long-term fluctuations in body weight may reflect changes in energy balance, illness, or intentional weight loss. However, their association with subsequent triglyceride concentrations remains uncertain. Objective: To examine the association between long-term weight v...

Implementing prospective probabilistic scheduling of surgical cases to yield more predictable utilisations

We studied the impact of a prospective, probabilistic scheduling method to replace surgeon-led booking, balancing contradictory goals of maximizing theatre utilised time while minimizing risk of over-utilised time. Implemented in an NHS Scotland hospital, the study analyzed 2420...

Impact of oxygen and hydrogen traces on the focused ion beam sputter rate and secondary ion mass spectrometry intensity detection of graphite

Trace amounts of oxygen and hydrogen can strongly influence the formation of negative carbon ions during focused ion beam–secondary ion mass spectrometry (SIMS) analysis of graphite. In this study, the sputtering behavior of graphite and the detection of single and clustered carb...

Antimicrobial effectiveness within a new paradigm of infrastructure

Antimicrobials form the backbone of modern medicine and represent a foundational pillar of economic productivity. Overuse and misuse have led to a rising trend of antimicrobial resistance (AMR), depleting the efficacy of existing antimicrobials, necessitating conservation through...

Evolution of water clarity across the Beijing-Tianjin-Hebei region over the past four decades (1984–2024): Driven by hydrological expansion and anthropogenic intervention

Given escalating water scarcity and rapid urbanization, characterizing the long-term evolution of surface water environments across the Beijing-Tianjin-Hebei (BTH) region is vital for coordinated regional development. Using Landsat imagery spanning 1984–2024, this study quantifie...

Drug-specific effects of anxiety on high-dose oxycodone: age as a modifier for oxycodone response

To investigate the association between preoperative anxiety and opioid tolerance in patients undergoing primary hip arthroplasty, focusing on heterogeneity across opioid types and the mechanisms underlying this association, this retrospective cohort study identified 1763 such pat...

Durability of wrist denervation for osteoarthritis: a multicentre outcome study

INTRODUCTION: Traditional surgical treatments for wrist osteoarthritis, such as arthrodesis or arthroplasty, are invasive and irreversibly compromise joint motion. Wrist denervation offers a less invasive alternative aimed at pain relief while preserving mobility. However, its du...

Research on the Impact Mechanism and Spatial Effects of the Digital Economy on Regional Economic Resilience in the Yellow River Basin of China

Against a backdrop of rising macroeconomic uncertainty, the digital economy has become a key driver of regional economic resilience. However, research on this relationship still requires further refinement for the Yellow River Basin, a special region characterized by ecological r...

Neuropeptide Alterations in Type 2 Diabetes Mellitus: A Meta‐Analysis of Circulating Spexin and Galanin Levels

ABSTRACT Background Spexin and galanin are neuropeptides involved in glucose homeostasis, insulin sensitivity, appetite, and energy metabolism. We conducted a systematic review and meta‐analysis to synthesise evidence on circulating spexin and galanin concentrations in patients w...

Seemingly conscious AI risks

AI systems are increasingly designed in ways that lead users to perceive them as conscious. This paper provides a unified framework connecting empirical hallmarks of consciousness attribution to a structured risk taxonomy of Seemingly Conscious AI (SCAI), AI systems that exhibit...

CNN-GRU-KAN: A Novel Multi-Branch Framework for Parkinson’s Disease Detection Based on Gait Classification

Parkinson’s disease (PD) diagnosis and severity assessment increasingly rely on gait analysis. To capture complex gait dynamics from limited sensor data, we propose a novel multi-branch framework integrating a one-dimensional convolutional neural network (1D-CNN), a bidirectional...

Revisiting the Indian Oedipus: The Phallus is (Also) Female

This paper revisits the psychoanalytic concept of the Oedipus complex through the lens of Indian psychoanalytic theory, Hindu goddess traditions, and clinical material drawn from work with Indian and diasporic patients. Challenging Eurocentric models that center paternal interdic...

Bottlebrush Polyolefin Sulfones as Triggerable and Degradable Pressure‐Sensitive Adhesives

ABSTRACT The molecular architecture (topology) of bottlebrush polymers, featuring densely grafted side chains along a polymeric backbone, leads to unique physical properties, enabling their use as functional materials including elastomers and pressure‐sensitive adhesives (PSAs)....

Integrated Quantum Dot Microsphere-Based MultiplexLateral Flow Immunoassay for On-Site Hazard Screening of Azole AntifungalResidues in Ecological Environment and Aquatic Products

Abstract As widely applied azole antifungal agents, climbazole (CBZ), clotrimazole (CLZ), and isavuconazole (ISKZ) can persist in environmental media and bioaccumulate in aquatic organisms, thus bringing hidden risks to the ecological environment and aquatic products. Herein, a c...

Multiple Myeloma Complicating Breast Cancer During Treatment: A Case Report

Research Background: Breast cancer is a malignant tumor that threatens women’s health. Among breast cancer patients, about 4.2% to 17% may suffer from multiple primary malignant neoplasms. Cases of patients suffering from both breast cancer and multiple myeloma are relatively rar...

Bankruptcy Prediction from 10-K Narratives: Evidence from Interpretable Text Scores and Accounting Baselines

This study examines whether context-validated acute distress disclosures in annual Form 10-K filings improve bankruptcy-risk ranking beyond accounting variables. The analysis links U.S. Securities and Exchange Commission filing data, Item 7 Management’s Discussion and Analysis te...