Research works

Effectiveness of mepolizumab in eosinophilic asthma and chronic rhinosinusitis with nasal polyps.

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory disease affecting 2-4% of the population which has a significant impact on quality of life. Approximately 40% to 60% of people with CRSwNP also have eosinophilic asthma, reflecting the unified airway conc...

MASS CODE 2026: AUTONOMOUS SHIPPING GOVERNANCE AND THE GLOBAL SOUTH

In May 2026, the International Maritime Organization (IMO) adopted the Maritime Autonomous Surface Ships Code (MASS Code) through Maritime Safety Committee resolution MSC.595(111), establishing the first international regulatory framework for autonomous cargo shipping (Internatio...

A study protocol for developing an implementation strategy bundle to enhance adoption of pediatric familial hypercholesterolemia screening

Familial hypercholesterolemia (FH) is the most common primary lipid disorder of childhood, affecting 1 in 250–350 children. Universal childhood cholesterol screening is an opportunity for earlier and more effective FH diagnosis and treatment that is superior to adult screening in...

From Comprehensive Distrust to Unquestioned Trust in Street-based Outreach Work With People Who Use Drugs in Finland

People who use drugs may experience comprehensive distrust in other people due to drug-related stigma and other violating experiences in services and in their life course. This may prevent them from seeking help. The goal of strengthening trust in services has been supported in s...

Pinyin or English? Navigating identity and intelligibility in China’s linguistic landscape

Abstract This study examines public perceptions of replacing English with Pinyin on subway signs, a shift that occurred in China in 2022. Drawing on 2,064 comments collected from Bilibili, a popular Chinese social media platform, it explores how public attitudes toward the change...

Physical activity promotes clinical benefits beyond dopaminergic preservation in Parkinson’s disease: a longitudinal analysis of the PPMI cohort

Abstract Background Physical activity is associated with better clinical outcomes in Parkinson’s disease (PD). This study aimed to investigate the effects of physical activity on longitudinal changes in dopamine transporter (DAT) availability and motor and cognitive outcomes. Add...

Screen Use, Child Development and Family Involvement in Children Aged 2–7 Years: A Systematic Review

INTRODUCTION: This study aimed to explore the effects of screen time on the development of children and the mediating role of families, following the PRISMA method. METHODS: Searches were conducted in Web of Science, Scopus and ERIC databases between 2020 and 2025. Eighteen artic...

Early-life exposure to plastics is associated with health parameters and biomarkers in southern giant petrels

The sub-lethal effects of plastics and their associated chemicals on wildlife are poorly understood, primarily due to the lack of reliable indicators. We used southern giant petrels ( Macronectes giganteus, SGP), key scavengers and predators in southern seas, to assess whether ea...

Oral Nicotine Pouch Use and Associations with Periodontal Status and Salivary Microbiome Dysbiosis

OBJECTIVES: Oral nicotine pouches (ONPs) are increasing in use, yet data on potential oral health effects are scarce. We evaluated whether ONP use is associated with clinical periodontal measures and salivary microbiome dysbiosis in a field-based regional sample. We recruited fir...

Buying Risk: Illegal Drug Purchases via Social Media Among Adolescents. Prevalence and Psychosocial Correlates from the ‘LifeOnSoMe’ Study

Adolescent drug use remains a significant public health concern, and the emergence of social media as a platform for purchasing illegal drugs adds complexity to this issue. This study investigates the prevalence and characteristics of Norwegian adolescents who report buying illeg...

Unified Fluctuation Geometry III:Microscopic Reconnection Dynamics, Defect Spectrum, and the Internal Spectral Action

Part III of the Unified Fluctuation Geometry (UFG) series develops the microscopic and internal-spectral sector of the framework. Starting from reconnection events endowed with retarded memory, the construction introduces a UFG-native noncommutative bivector and propagates this s...

Bacterial Community Structure and Heavy Metal Adaptation in Soils from a Gold–Copper Mining Area in Bulgaria

Heavy metal/loid (HM) pollution of soils, primarily as a consequence of mining and ore-processing activities, poses significant risks to ecosystems and human health. Soil microbial communities play essential roles in maintaining key ecosystem functions, including nutrient cycling...

The functional role of eggs and plant-based alternatives in cake systems: design considerations based on colloidal and structural dynamics

Eggs play a critical role in bakery products, providing essential functionalities such as foaming, emulsification, and gelation, leading to structure formation. Traditional egg replacement approaches rely on trial-and-error methods focused on matching texture and sensory properti...

Maximizing water and nitrogen productivity in aerobic rice through optimized drip irrigation and nitrogen fertilization

Global water scarcity and nitrogen (N) fertilizer pollution threaten the sustainability of rice production, necessitating a shift towards water and N-efficient cultivation methods. This two-year study aimed to optimize water and N productivity in aerobic rice by assessing four dr...

Mood Modulates, It Doesn't Gate: Orthogonal Task-State and Affective-State Composition in Persistent Agent Systems

Many persistent AI agents are organized around a request-response loop in which the language model serves as the primary decision-making runtime. In such systems, affective state—when represented at all—is often coupled directly to behavior: changes in mood can gate actions or al...

The role of knowledge transfer at non-state universities – the example of Germany

The German higher education system has undergone considerable structural change in recent years. The previously small group of non-state universities has grown significantly. Over a third of all Higher Education Institutions in Germany are now private or church-run, and the numbe...

Structural Diversity and Differential Natural Pairings of MAT1-1-1 and MAT1-2-1 Proteins Essential for Sexual Reproduction in Ophiocordyceps sinensis Strains

The MAT1-1-1 and MAT1-2-1 proteins perform essential DNA-binding activities and regulation of the transcription of genes governing sexual reproduction in Ophiocordyceps sinensis. Previous studies have documented differential occurrence, alternative splicing, and transcriptional d...

The Knowledge Premier League: Power Play Dynamics

Every enterprise delivery organization pays an "Ignorance Tax"—the accumulated cost of context that fails to transfer, expertise concentrated in single individuals, and training programs measured by compliance rather than capability. This white paper introduces the Knowledge Prem...

National Milk Output and Producer Structure in Kazakhstan: An Exploratory Econometric Assessment and Evidence-Informed Policy Discussion

The continued prominence of household production characterizes Kazakhstan’s dairy sector, but the aggregate relationships between this producer structure, animal productivity, wider livestock-sector activity, and national milk output have not been examined over a common recent se...

Defining global priorities in hematopoietic transplantation and cellular therapy: a statement paper from EBMT Global ComMittee

Abstract Hematopoietic cell transplantation, cellular and gene therapies, and (CAR)-T cells have revolutionized outcomes in hematologic disorders. However, major disparities persist in their availability, accessibility, and affordability, particularly in low- and middle-income co...