Effectiveness of mepolizumab in eosinophilic asthma and chronic rhinosinusitis with nasal polyps.
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Abstract
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory disease affecting 2-4% of the population which has a significant impact on quality of life. Approximately 40% to 60% of people with CRSwNP also have eosinophilic asthma, reflecting the unified airway concept characterised by type 2 inflammation driven by interleukin (IL)-4, IL-5 and IL-13.
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Authors: E Chiner, I Boira, J L Lafuente, M Antón, M A Bernabeu, P Fernández, V Esteban, M Llombart
Institutions: Universitat de Miguel Hernández d'Elx, Hospital Universitari Sant Joan D'Alacant