Research works

SNX4 promotes glioblastoma progression through the TGFβ1/Smad signaling pathway and represents a potential therapeutic target

Abstract Background Glioblastoma multiforme (GBM) is a highly malignant primary brain tumor that still lacks highly specific and clinically effective molecular targets for GBM treatment. Sorting Nexin 4 (SNX4) is an important regulatory molecule involved in intracellular membrane...

Advances in Smart Responsive Nanofibers for Wound Healing

Wound healing, particularly chronic wound healing, is a complex and dynamically regulated process that is commonly challenged by wound infection caused by the invasion of various bacteria. The emergence of nanofibers has overcome the limitations of traditional wound dressings in...

Off-Target Retinal Pigment Epithelium (RPE) Expression of Cre in the Rhodopsin-iCre75 Mouse Line

Purpose: Cre mouse lines are an important tool to manipulate gene expression in specific cell types and at distinct developmental timepoints. Overlooked and off-target expression of Cre is a common issue with transgenic Cre lines that has confounded the interpretation of many stu...

Coupled Photon Transport and Interfacial Charge Utilization in ACT/g‐PAN for Photocatalytic CO 2 Reduction

ABSTRACT Integrating microscopic catalyst design with macroscopic photophysical reaction engineering is important for improving solar‐driven CO 2 reduction. However, previous studies have largely focused on the molecular‐level optimization of catalysts, whereas the coupled effect...

Defining STING activity

Mapping mutations to cellular outcomes reveals the molecular mechanisms underlying STING activity.

Society for Maternal‐Fetal Medicine Special Statement: Checklists for persons with sickle cell disease in pregnancy

Abstract This article presents checklists designed to guide clinicians in the comprehensive management of pregnant individuals with sickle cell disease, including prepregnancy, antepartum, delivery, and postpartum care, as well as the specific management of vaso‐occlusive crises....

EuroMillions Breakthrough Mining — 1689 Sources, 12388 Leads Extracted — E8 Intelligence Research

Mined 1689 lottery+quantum breakthroughs. Extracted 12388 leads across 13 categories. 10402 high-value leads found. Categories: {"CORRIDOR": 1028, "FORMULA": 872, "GEOMETRIC": 718, "FORWARD_ATTEMPT": 1077, "QUANTUM": 1290, "TIMING": 204, "CELESTIAL": 956, "GEMATRIA": 1024, "CONST...

Authentication of a Heterogeneous Information and Control Network of Autonomous Oceanographic Platforms Based on a SAW-PUF Architecture

Protecting a heterogeneous information and control network of autonomous oceanographic platforms (surface buoys and underwater gliders/probes) requires authentication protocols built on the multichannel AlN-SAW physical unclonable function (PUF) architecture proposed in the autho...

Periodontal Dysbiosis and Psoriatic Arthritis: From Oral Threshold Modification to Post-Enthesitic Synovial Amplification

Abstract Background Psoriatic arthritis (PsA) is not well explained by directly importing the Porphyromonas gingivalis–PPAD–ACPA model from rheumatoid arthritis (RA): PsA is usually seronegative and has an enthesis-centered anatomy. This note develops a distinct hypothesis: chron...

Inspection-Oriented Predictive Quality Modeling for MDF Manufacturing Using Industrial Process Data and Machine Learning

Continuous medium-density fiberboard (MDF) production presents a persistent quality-assurance problem: destructive laboratory tests return results too late to prevent off-specification material from accumulating before a corrective response is possible. This study develops an ins...

AOPQ-Net Acoustic–Optical Proposal Query Network for Underwater Multimodal Object Detection

Optical cameras and imaging sonars are widely used sensors in autonomous underwater vehicles. However, their different imaging mechanisms introduce substantial cross-modal discrepancies in the acquired data. In addition, underwater optical images are often degraded by low illumin...

From ‘Emotional Storm’ to Post-Traumatic Growth Among Caregivers of Individuals with Mental Illness and Substance Use Disorders: An Integrative Review

Background/Objective: Family caregivers of individuals with serious mental illness and substance use disorders experience substantial psychological burden. However, emerging evidence suggests many develop resilience and post-traumatic growth despite adversity. This integrative re...

Research and advances in TK1-mediated metabolic reprogramming in modulating the tumor immune microenvironment in hepatocellular carcinoma

Abstract Hepatocellular carcinoma (HCC) is still one of the leading causes of cancer-related deaths in the world. It is characterized by significant metabolic disorders and immunosuppressive tumor microenvironment(TME). As a key enzyme in the thymidine remedy pathway, TK1 is trad...

Groundwater Aquifer Characterization and Potential Assessment of the Shallow Aquifers in the Volcanic Highlands of Northwestern Ethiopia

Estimating transmissivity and hydraulic conductivity is crucial for groundwater resource assessment, flow modeling, pollution remediation, and sustainability studies. In the volcanic highlands of Ethiopia, millions rely on hand-dug wells and springs for drinking and irrigation, y...

The training paradox: when and how technical training enhances or constrains team performance in an emerging economy context

Purpose This study aims to investigate the paradoxical effects of technical training on team performance. Although organizations invest heavily in employee training to enhance competitiveness, the link between training and performance remains inconsistent. Drawing on the Resource...

Noninvasive 3D mapping of tissue stress using reverberant shear wave

Abstract Mechanical stress is a fundamental aspect of soft tissues that influences cellular behavior and tissue integrity, yet noninvasive imaging of stress in vivo remains a major challenge. Conventional magnetic resonance elastography (MRE) measures tissue stiffness but not str...

Egg Cannibalism Affects Growth Development, Reproduction, and Fitness of Aphidophagous Coccinellids, Hippodamia variegata, and Menochilus sexmaculatus

ABSTRACT We investigated how egg cannibalism affects growth, development, reproduction and progeny fitness of aphidophagous coccinellids, viz. Menochilus sexmaculatus (Fabricius) and Hippodamia variegata (Goeze). Egg cannibalism provided immediate benefits to first instars by exp...

Exploring the impact of social media on adolescent and young adult mental health

Social media platforms offer potential benefits for mental well-being by fostering social connections, enabling self-expression, and democratizing access to mental health resources. Yet, concerns have been raised regarding their association with mental health problems, particular...

Authenticity over automation: how AI-mediated sustainability communication shapes trust and green purchase intention

Purpose Drawing on signalling theory and trust theory, this research aims to explore how consumers’ perceptions of AI involvement in sustainability communication shape perceived authenticity, green brand trust and green purchase intention. It also investigates whether perceived g...

Trichlorination by a single cyanobacterial halogenase in the biosynthesis of lebomboamide A

Halogenation is a widely used strategy, both in nature and medicinal chemistry, to modulate the properties of small molecules. Cyanobacteria are a rich source of halogenases that act regio- and stereoselectively on sp3-hybridized carbon centers, which have been reported to cataly...