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Hormonal therapies for endometriosis-associated pain: inflammatory limitations and pharmacological challenges

Endometriosis is a chronic inflammatory and estrogen-dependent disease in which pain remains the leading cause of impaired quality of life. Hormonal therapies constitute the cornerstone of medical management and include progestins, combined estrogen-progestin contraceptives, gona...

Heritable, Prenatal, and Environmental Pathways of Parental Stress: Differential Influences on Children’s Effortful Control and Cortisol Regulation

Parental stress can have lasting consequences on children’s stress sensitivity and self-regulation capacities. However, it remains unclear the extent to which these effects reflect birth parent influences (genetic and/or prenatal), environmental rearing experiences, and/or intera...

N-(4H-1,2,4-triazol-4-yl)imines as Versatile and Readily Accessible Precursors for Nitrile Synthesis

Abstract Herein, we report the selective transformation of N‑(4H‑1,2,4‑triazol‑4‑yl)imines into substituted benzonitriles. These imines are readily accessible from aldehydes. The method provides a rapid and mild procedure that utilizes a previously undescribed nitrogen source. Th...

Quantitative evaluation of defect parameters in magnetic flux leakage testing based on an improved magnetic dipole model and convolutional neural networks

Acquiring low-cost magnetic flux leakage (MFL) signals while accurately inverting defect geometric parameters remains a significant challenge in magnetic flux leakage non-destructive testing. To address this issue, this paper proposes a simulation-driven defect inversion framewor...

Computed tomography-derived body composition parameters as potential predictors of severity and adverse outcomes in viral pneumonia: a retrospective study

Background Following the COVID-19 pandemic, co-infections with multiple respiratory viruses have become increasingly common, complicating the accurate prediction of disease progression and prognosis. This study assessed the use of computed tomography (CT)-derived body composition...

Quantum Coherence Enables >99% Efficiency in Photosynthetic Energy Transfer — E8 Intelligence Research

FINDING: Quantum coherence in photosynthesis enables near-perfect energy transfer efficiency via delocalized excitonic states, with evidence of wavelike energy propagation through protein complexes. MATH: - Energy transfer efficiency >99% in Fenna-Matthews-Olson (FMO) complex - C...

Proactive Civil Registration Services: Evaluating the "Jemput Bola" Innovation in Improving Population Administration Access in Animha District, Merauke Regency, Indonesia

Access to population administration services remains a persistent challenge in Indonesia's frontier, outermost, and disadvantaged (3T) regions, where geographic isolation and limited infrastructure restrict citizens' ability to obtain identity documents that underpin their admini...

Cardiac Opioid System and Its Role in Heart Failure and Ischemia–Reperfusion Injury

Opioid receptors and peptides act as modulators of cardiac and vascular function. These effects are mediated not only by central mechanisms but also via a local cardiac opioid system, which has gained increasing attention for its potential role in cardiovascular disease and perio...

Long-Term Recovery Trajectories After Endovascular Treatment of Carotid-Cavernous Fistulas: A Single-Center Cohort Study

BACKGROUND AND OBJECTIVES: Carotid-cavernous fistulas (CCFs) are uncommon arteriovenous shunts that can present with a wide range of nonspecific ophthalmic and neurological symptoms, often leading to diagnostic delays. While endovascular embolization is the primary treatment moda...

Intrapartum Febrile Morbidity and Maternal Birth Trauma After Vaginal Delivery: A Parity-Stratified Retrospective Cohort Study

Objective: We aimed to evaluate the association between intrapartum febrile morbidity and maternal birth trauma among women undergoing vaginal delivery, with stratification by parity. Methods: This retrospective cohort study included women with singleton, cephalic, vaginal delive...

Boundary of the Maximum Depth Hyperparameters of the Random Forest Leading to the Highest Accuracy Discovered by Single-Tree Techniques

Abstract Random Forest (RF) is a widely used ensemble learning method known for its high classification accuracy. However, optimizing its numerous hyperparameters remains a persistent challenge, particularly the Maximum Depth (MaxDepth) of individual trees. This study examines th...

From attraction to retention: a qualitative inquiry into AI influencer stickiness

Purpose The purpose of this paper is to investigate the psychological and behavioral factors that explain why consumers remain engaged with artificial intelligence (AI) influencers. The study specifically explores the construct of “stickiness” – the ability of AI influencers to a...

Thermal‐Induced Loose Solute Configuration Activates Organic Electrolyte for Zinc Metal Battery

ABSTRACT Zinc metal batteries face issues of low coulombic efficiency and persistent side reactions due to the active H 2 O in aqueous electrolytes. Organic electrolytes that can reduce side reactions and coulombic efficiency loss still suffer from sluggish Zn 2+ transfer and dif...

Simulation-based inference for AGN jet population modelling: Towards more robust comparisons of black hole jet speeds

Abstract We present the most complete modelling of the MOJAVE 1.5 Jansky Quarter Century active galactic nuclei (AGN) jet population, using likelihood-free simulation-based inference. Due to the complex impact of a flux-limit on observed AGN data sets, careful modelling of the pa...

MODEL ADOPTION #897: REJECT — LEDGER BENCH: Apply filter: Phase distance TIGHT (<=2deg) — improves win rate from 31.6% t — E8 Intelligence Research

DECISION: REJECT ELEMENT: The phase distance filter (≤2°) is not adoptable because the backtest (n=391) is too small to distinguish signal from noise, and the live shadow-test proposed is a 30-day forward test, not a replay-bench against historical E8-node/Gods-Clock data. The 3....

Aging geographies: epistemology and ontology of gerontospace

This article develops the epistemological and ontological foundations of the geographies of aging by positioning gerontospace as a central analytical category through which aging is spatially produced and experienced. Gerontospace emerges from the intimate relationship between th...

The Role of Lachnospiraceae in Liver Diseases: Recent Advances and Clinical Application Prospects

Chronic liver diseases impose a considerable global public health burden, yet available treatment options remain largely inadequate. The gut microbiota exerts a key modulatory effect on liver disease pathogenesis via the gut-liver axis. Among them, Lachnospiraceae, a dominant bac...

Hepatocyte-intrinsic ER stress and NRF2 initiate primary sclerosing cholangitis, providing therapeutic insights

primary sclerosing cholangitis (PSC) is a severe liver disease that can progress to cholangiocarcinoma. Therapeutic development has been hindered by the rarity of PSC and by its poorly understood origin, which reflects incompletely defined genetic and environmental risk factors....

Key components for responding to burn mass casualty incidents: a comprehensive systematic literature review

Effective management of burn mass casualty incidents (BMCIs) requires coordinated systems that include early stabilization, definitive burn care, surge capacity, and rehabilitation, supported by adequate infrastructure and workforce capacity. Although different countries have nat...

Somatic, Psychiatric and Neurodevelopmental Comorbidities in People with Autism Spectrum Disorder (ASD): A Narrative Review

Background/Objectives: Autism spectrum disorder (ASD) is currently singularly described as a behaviourally defined neurodevelopmental diagnosis with symptoms affecting social communication and social understanding alongside the presence of restricted patterns of behaviour. Wide,...