Research works

Genetic Diversity and Hospital Circulation of Opportunistic Pathogens in COVID-19 ICUs: Whole-Genome Sequencing Data

The COVID-19 pandemic led to a dramatic increase in healthcare-associated infections and antimicrobial resistance, particularly in intensive care units (ICUs). The aim of this study was to provide a comprehensive genomic characterisation of all clinically significant opportunisti...

PFUSRC-080 Topological Morphogenesis of the Collatz Conjecture — From 3n+1 Iteration to 45° Biconical Interlayer Oscillation: Tracing a Number-Theoretic Problem to Its Geometric Boundary

The Collatz conjecture (3n+1 problem) is a classic unsolved problem in number theory. Its iteration rule is: for any positive integer n, if n is odd, map n \to 3 n+1; if n is even, map n \to n / 2. The question is whether repeated iteration necessarily converges to 1 for all init...

Fatigue Induced by Walking Uphill and Downhill Similarly Disrupts Postural Balance but Their Disruptive Factors Differ

Background/Objectives: Walking-induced fatigue disrupts postural balance, but the differentiated effects of walking uphill and downhill remain unclear. The aim was to compare the impact of two walking sequences, either uphill (+10%) or downhill (−20%), with an identical number of...

Quasi-Random Sampling-Enhanced Metaheuristic Algorithms for CAMD-Based Solvent Selection in Octacosanol Extraction

This study develops a computer-aided molecular design (CAMD) framework to select solvents for extracting octacosanol from multicomponent sugarcane wax. The solvent-selection problem is formulated as a mixed-integer nonlinear programming problem in which candidate solvents are gen...

Endogenous Neurotoxicity: A Pathophysiological Consequence of Homeostatic Dysfunction

Neurotoxicity is generally thought to result from exogenous agents like environmental chemicals, drugs and biological toxins. However, increasing evidence suggests that many endogenous molecules that play a critical role in normal brain function can become neurotoxic when the reg...

From real-world events to open POI data: a measurement protocol for time-to-reflection, with a benchmark from Japanese official registers

Background Open point-of-interest (POI) datasets increasingly carry temporal fields—Foursquare OS Places attaches creation and closure dates to over 100 million places and feeds Overture Maps—inviting longitudinal research that depends on a quantity never systematically measured:...

PFUSRC-066 The Origins of Mass: From Breaking to Topological Latching — A Repositioning of the Higgs Mechanism within the PFUSRC Framework

The Standard Model of particle physics relies on the Higgs mechanism and spontaneous symmetry breaking to fit elementary particle masses, yet it has an inherent ontological blind spot. It fails to explain the generative origin of symmetry breaking and cannot unify spontaneous and...

Valuation Boundaries in Monetary Ecosystem Service Assessment: A Logic-Chain-Based Reporting Framework with a Vineyard Application

Monetary ecosystem service (ES) valuations often differ across studies even when similar methods are applied because available data implicitly determine which biophysical, management, and demand-side drivers are represented. These implicit “valuation boundaries” are rarely report...

Facile synthesis of platinated DNA nanoparticles with radiosensitizing potential

DNA nanostructures are promising drug delivery platforms but often suffer from limited structural stability and high production complexity. Cisplatin can cross-link DNA and act as a therapeutic agent, offering a simplified approach to stabilize DNA nanostructures while incorporat...

Characterization of Sec14 Domain–Containing Proteins in the Malaria Parasite Plasmodium falciparum

ABSTRACT Plasmodium falciparum parasites cause the most virulent form of malaria, a disease that remains a major global health burden. The appearance of resistance to first line artemisinin‐based therapies emphasizes the need to identify new parasite vulnerabilities to develop ne...

Columnwise neural imputation for incomplete ordinal psychometric data.

COLNI (pronounced “col-knee”) is an ANN-based framework for imputing missing values in tabular data, with a particular focus on ordinal response scales frequently encountered in education, psychology, behavioral science, and related domains. Extensive simulation studies and real-...

Local symmetry and the dependence on extended spacetime

We show that linearised E theory possesses a local symmetry at low levels provided the parameters of the local symmetry obey differential conditions that restrict their dependence on the extended spacetime. In the decomposition of E theory that leads to Siegel theory, also known...

We Have Come to Be Destroyed: Growing Up in Cold War Britain

Asked to imagine her future life by the 1969 National Child Development Study, one 11-year-old girl described what she felt would be the difficulties of working motherhood: in the early morning she...

Ex Machina

This essay examines romantic relationships between humans and AI companions, focusing on how technological breakdowns are experienced as emotional crises. Drawing on digital ethnography and interviews, it explores how users interpret their AI’s malfunctions—such as hallucinations...

THFR-1.12: Operator-Level Clarification of QCRS, Biomorphic Projection, and Collective Invariant Field (CIF) Formation

This paper establishes a consistent operator-based ontology for the Theory of Harmonic Field Resonance (THFR), providing a formal framework eliminating explicit biological circularity by clarifying the operator-level status of the Quantum Coherent Reduction System (QCRS) prior to...

A Study of Bubble Dynamics on the Dielectric Recovery Underwater Discharge

In this paper, a numerical method was used to study the dielectric recovery characteristics underwater discharge. The Keller-Miksis equation was used to study the bubble evolution, considering the internal thermodynamic parameters. The temperature and pressure inside the bubble w...

Prediction of Iron Wear Metal Concentration in Used Engine Oils from FT-IR Spectra Using Partial Least Squares Regression

Wear metal monitoring is an important component of lubricant condition monitoring but commonly relies on elemental techniques such as inductively coupled plasma optical emission spectroscopy (ICP-OES), which require dedicated laboratory infrastructure and sample preparation. This...

Artificial hibernation reveals synaptic engram architecture associated with memory retention

Memories leave lasting physical changes at the synaptic level. Although stable, larger spines are thought to support memory, the high turnover of dendritic spines and the drifting of neuronal representations after memory formation suggest alternative possibilities. To elucidate t...

THFR-1.11: Canonical Notes and Ontological Unification of the First Series

This meta-document establishes the definitive canonical interpretative framework for the entire initial series of the Theory of Harmonic Field Resonance (THFR-1.1 to THFR-1.8). Moving beyond the historical chronology of the theory's formulation, we deploy a strict deductive align...

Traditional Weather Forecasting in the Age of Climate Change: Folk Meteorology, Indigenous Knowledge, Disaster Preparedness, and Coastal Resilience in the Philippines

Despite increasing attention to disaster risk reduction and climate adaptation in the Philippines, limited research has examined folk meteorology as a culturally embedded system of local ecological intelligence among coastal communities. Existing studies often prioritize scientif...