Research works

Builder Engine 3.5.7: Blueprint of a Verifiable Architecture Language and System Factory

Builder Engine is two things in one system: a language in which architecture is declared as verifiable constraints, and a factory that builds a system from that contract. The inversion that defines the language is that it does not state what a system is but what cannot happen in...

Comparison of autologous platelet-rich plasma injection with air tamponade versus C3F8 tamponade in idiopathic full-thickness macular hole surgery

Vitrectomy, combined with internal limiting membrane peeling and gas tamponade, is the gold standard for treating full-thickness macular holes (FTMH). However, prolonged intraocular tamponade duration often causes patient discomfort and delays visual recovery, necessitating the n...

Awareness and perceptions of patient and public involvement in rare disease research in Japan: the role of patient advocacy groups and family members

Abstract Background Patient and public involvement (PPI) in medical research has increasingly been incorporated into research policies and funding frameworks in Japan, but empirical evidence on how patients and family members perceive PPI remains limited. This is particularly imp...

Synthesis of (FeCoNiCuMn)S high-entropy sulfide nanorods and its enhanced oxygen evolution reaction performance

High-entropy sulfides (HESs) have emerged as promising electrocatalysts for the oxygen evolution reaction (OER) due to their unique compositional tunability and synergistic effects. In this work, we report the rational synthesis of (FeCoNiCuMn)S HES nanorods via a facile hydrothe...

Electron Transferto Colloidal ZnO Nanocrystals fromthe Excited State of a Perylene Chromophore Formed by Direct Excitationor Triplet–Triplet Annihilation Upconversion

Abstract Upon binding 4-(perylen-3-yl)benzoic acid 1, to oleate-capped ZnO nanocrystals (NCs), significant broadening of the perylene absorption spectrum and fluorescence quenching were observed. In contrast, no broadening of the absorption spectrum or fluorescence quenching was...

Media, police shootings and mental illness: Is stigma a problem?

Objectives: Fatal police shootings in Australia have increased in recent years, with a substantial portion of these incidents involving individuals with mental illness and often attracting extensive media coverage. This study investigates whether mainstream newspaper reporting us...

LAB #969 NEUTRAL: LEDGER BENCH: Apply filter: Pool density HIGH (>=90) — improves win rate from 31.6% to 33.2% (+1.6pp — E8 Intelligence Research

IDEA: Adjustment made to the live model — verify against the backtests: Apply filter: Pool density HIGH (>=90) — improves win rate from 31.6% to 33.2% (+1.6pp, n=1328) **SAME-WINDOW EFFECT:** Applying the HIGH pool density filter (≥90) to the live window would have rejected the E...

An Intelligent Framework for Forecasting Cardiovascular Disease using Bio-inspired Optimization and ML

Inderscience is a global company, a dynamic leading independent journal publisher disseminates the latest research across the broad fields of science, engineering and technology; management, public and business administration; environment, ecological economics and sustainable dev...

A generalized artificial neural network (ANN) model for predicting construction project durations based on cost and geolocation data

Purpose Reliable construction project duration estimation remains a persistent challenge due to the complex interactions among project characteristics and the diversity of construction environments. While previous prediction models have frequently relied on project-specific varia...

An Essential Parameters of Clostridium Perfringens Infection Include Objectives, Etiology, Epidemiology, Pathophysiology, Histopathophysiology, Diagnosis, Differential Diagnosis, Treatment and Prognosis

The anaerobic Gram-positive spore-forming bacillus Clostridium perfringens is linked to acute gastrointestinal infections in people that range in severity from diarrhea to necrotizing enterocolitis and myonecrosis. This pathogen can produce spores that are resistant to environmen...

Mechanisms of Multi-Toxicant Oxidative Stress: Dysregulation of The NF-Κb/Iκb Axis By Ozone, 4-(N-Methyl-N-Nitrosamino)-1-(3-Pyridyl)-1-Butanone (NNK) and/or Dibutyl Phthalate (DBP)

ABSTRACT This study explores the NF-κB-mediated oxidative stress pathways in B6C3F1 mouse lungs and livers following 16- and 32-week exposures to ozone, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and/or dibutyl phthalate (DBP). EMSA and Western blot analyses reveal...

Post-Traumatic Stress Symptoms and Dissociation in Emergency Medical Service Personnel

Background: Emergency medical service (EMS) personnel and volunteers are frequently exposed to traumatic events, placing them at elevated risk for psychological distress, including post-traumatic stress symptoms (PTSSs), depression, and dissociation. This study examined the relat...

Immune checkpoint blockade sensitivity is linked to endogenous retroelement transcriptional changes in cancer

Abstract Endogenous retrotransposable elements (EREs) can modulate immune responses. We explored ERE transcription in relation to response to immune checkpoint inhibition in advanced solid tumors. ERE expression was measured in pre and on-treatment samples from patients treated i...

In-human assessment of target engagement and blockade of radiolabeled BI 765063, an anti-SIRPα antibody

The signal regulatory protein alpha (SIRPα) receptor on myeloid cells binds cluster of differentiation (CD) antigen CD47 on tumor cells, resulting in a “don’t eat me” signal that inhibits phagocytosis. BI 765063, an anti-SIRPα antibody, may restore anti-tumor immunity by blocking...

Analysis of the application of computerized optokinetic nystagmus analyzer in vision examination

To investigate the practicability, accuracy, and consistency of the computerized optokinetic nystagmus (OKN) analyzer for visual acuity (VA) measurement. Cross-sectional consistency evaluation study. A total of 219 subjects (13.48 ± 12.89 years, 115 males, 104 females) underwent...

Sustainable Extraction of Tagetes erecta L.: Comparative Metabolomics and Antifungal Activity against Grapevine Pathogens

Abstract The spread of fungicide-resistant pathogens has increased interest in plant-based antifungal agents for agricultural applications. We compared subcritical CO2 extraction (SbFE), ultrasound-assisted extraction (UAE), hot reflux extraction (HRE), and Soxhlet extraction (SE...

Nano-enhanced bioremediation of soil co-contaminated with petroleum hydrocarbons and cadmium using Helianthus annuus L. plants

Abstract Background Simultaneously removing petroleum hydrocarbons (PHCs) and heavy metals from soil is a challenging task. This study aimed to evaluate the efficacy of green-synthesized nano zero-valent iron (nZVI) particles and a microbial consortium in combination with sunflow...

Disorder as an Anthropocentric Construction: A Phenomenological Critique of Order in Existence

A phenomenological critique of the concept of disorder as a supposedly objective feature of reality. The paper argues that order and disorder are human evaluative categories produced through cognition, biological interests, and social organization, while existence itself unfolds...

An Explanation forthe 32 and 54 Da Losses Seen in N -Linked GlycanPermethylation Reactions

Abstract Permethylation is a widely used derivatization technique for mass spectrometry-based glycan analysis, applicable to both research and drug product characterization. It stabilizes sialic acids, improves glycan ionization, and is commonly used to analyze PNGase F-released...

Collaborative Probabilistic Wind Power Forecasting Using Adaptive Flow Matching Enhanced Neural Process

ABSTRACT With the large‐scale integration of wind power, its inherent intermittency and uncertainty pose significant challenges to power system operation. Existing probabilistic forecasting methods often struggle with capturing spatiotemporal correlations among multiple turbines...