Research works

Selective Intrinsically Photosensitive Retinal Ganglion Cells Ablation Regulates Myopia Development Through the Choroid/MAPK Pathway

Purpose This study investigates the role of selective ablation of intrinsically photosensitive retinal ganglion cells (ipRGCs) in regulating axial length (AL) and scleral remodeling during myopia progression.Methods Three-week-old pigmented guinea pigs were randomly assigned to f...

MERTK inhibition cooperates with immunomodulatory cyclophosphamide to induce CXCL9⁺ monocyte-macrophage programming and durable antitumor immunity in triple negative breast cancer

ABSTRACT Triple-negative breast cancer (TNBC) has high rates of recurrence despite chemotherapy and immune checkpoint blockade (ICB). Tumor-associated macrophages (TAMs) can either suppress or support anti-tumor immunity, but the mechanisms governing these states and therapeutic...

Learning Sequences and Events in Individual, Pair and Group Data-Driven Learning

Abstract Previous research has shown that the learning process in data-driven learning (DDL) is cyclical, iterative, and non-linear, even when tasks are designed around seemingly linear pedagogical frameworks such as Illustration–Interaction–Intervention–Induction (Carter, Ronald...

Forecast-based attribution of the role of stratospheric variability in weather extremes

Abstract. Variability of the stratospheric polar vortex, particularly its dramatic breakdown during sudden stratospheric warming (SSW) events, has been linked to a number of surface weather extremes. However, attributing the role of stratospheric variability in a specific observe...

Neonatal diethylstilbestrol exposure disrupts uterine epithelial apical–basal polarity and partial EMT state

Abstract The developing female reproductive tract is highly sensitive to external hormonal stimulation, which can result in infertility and gynecologic diseases. To determine the underlying mechanisms, we used a mouse model to test the immediate, cell type-specific effects of neo...

Comparative Analysis of Leader Election Algorithms In Distributed Systems

Author-deposited reprint of the published article: Piotrovskyi, Y. (2026). Comparative Analysis of Leader Election Algorithms In Distributed Systems. International Journal of Computer (IJC), 57(1), 11–26. Original online publication date: February 1, 2026. Version of record: http...

On Global Weak Solutions for the Magnetic Two-Component Hunter–Saxton System

Abstract We study the magnetic two-component Hunter–Saxton system (M2HS), which was recently derived in [19] as a magnetic geodesic equation on an infinite-dimensional configuration space. While the geometric framework and the global weak flow were outlined there, the present pap...

Integrated omics analysis provides preliminary insights into the regulatory network controlling ethephon-promoted calyx abscission in Korla Xiangli (Pyrus × sinkiangensis Yü)

<title>Abstract</title> Background Calyx abscission is a key horticultural trait affecting fruit quality in Korla Xiangli <italic>(Pyrus</italic> × <italic>sinkiangensis</italic> Yü <italic>).</italic> Exogenous ethephon treatment has been shown to significantly promote calyx abs...

Incorporating data drift to perform survival analysis on credit risk

Survival analysis has become a standard approach for modelling time to default by time-varying covariates in credit risk. Unlike most existing methods that implicitly assume a stationary data-generating process, in practise, mortgage portfolios are exposed to various forms of dat...

Intraseasonal variability and eddy-induced structural modulation of the North Pacific intermediate water revealed by multi-mooring observations

Abstract. The North Pacific Intermediate Water (NPIW) plays a crucial role in modulating oceanic thermohaline circulation and biogeochemical processes. However, limited continuous observations have hindered the understanding of its short-term variability and structural response t...

Reconciling contradictory models of subthalamic nucleus contributions to basal ganglia beta oscillations

Recent computational studies of Parkinson’s disease have yielded contradictory findings regarding the role of the subthalamic nucleus (STN) in pathological beta oscillations, with some models implicating STN as essential for beta generation and others suggesting that STN suppress...

Linguistic and gender dynamics in sustainable tourism: A comparative analysis of Bali, Indonesia and Bukidnon, Philippines

This comparative study examines the linguistic characteristics of indigenous people men and women within tourism contexts in Bali, Indonesia and Bukidnon, Philippines. Data were obtained through observation method at each field site and semi-structured interviews also conducted,...

Application of neural networks for predicting convective impact heat transfer coefficients in post-rolling steel plate cooling

The water jet impingement boiling heat transfer coefficient (HTC) during controlled cooling after rolling is a critical parameter governing microstructural evolution and temperature distribution in steel plates. Conventional experimental measurement and numerical simulation appro...

Are AI language models scientific models of language?

Abstract There has been a recent surge of philosophical interest in AI large language models (LLMs) and their relevance for the understanding of human language. In this article, we take the perspective of the philosophy of science on modelling in general to consider whether LLMs...

Prospecting MeerKAT Continuum Data for Enigmatic Radio Sources with Unsupervised Vector-Quantised Variational Autoencoders

Abstract We present a novel application of Vector quantised variational autoencoders (VQ-VAEs) as an unsupervised tool to probe deep 1.28 GHz radio continuum images taken from the MeerKAT Galaxy Cluster Legacy Survey (MGCLS) and compare their performance to other machine learning...

Ascending and descending motor pathways converge in the centrolateral nucleus of the thalamus

<title>Abstract</title> Corollary discharge (CD) signals are copies of motor commands that inform the brain of impending movements. Dysfunction in CD has been implicated in a variety of disorders, from schizophrenia to Parkinson’s disease. In the current study, we used intersecti...

Compact Fuzzy Set: A Parameter-Free Unifying Approach for Flexible and Reliable Conflict Modeling in Group Decision Making

While the literature on fuzzy set extensions has expanded rapidly, this extension inflation has introduced significant reliability issues regarding the semantic consistency and practical validity of the proposed models. Specifically, high levels of disagreement among experts are...

Heatmap-seeded spatially grounded query Transformers improve astrocyte soma detection across Immunostains and scan resolutions

<title>Abstract</title> Background: Automated astrocyte quantification in human immunohistochemistry (IHC) is hindered by stain variability and dense clustering. Standard Transformers often miss faint somata due to agnostic initialization, while CNNs struggle with overlapping pro...

Size-DependentTernary Halide Solid Solutions in PerovskiteNanocrystals

Abstract Crystalline solid solutions incorporate guest atoms by substituting host lattice sites up to a solubility limit dictated by solute–host similarity. Solid solutions enable tuning of various material properties, such as the optoelectronic behavior of halide perovskites. In...

Biomass inventory optimization for willow-based pellet production integrating seasonal supply and stochastic demand

Biomass supply chains face both internal challenges (low energy density, bulkiness, seasonality) and external challenges (market uncertainty). We developed a two-stage stochastic mixed-integer linear programming (MILP) model that configures an (s, S) inventory control policy for...