Research works

Viral Nuclease Inhibitors: Small molecule disruptors of the UL12 alkaline nuclease display broad anti-herpes virus activity

Abstract Herpes simplex virus-1 (HSV-1) UL12 gene encodes a well-conserved 5’ → 3’ alkaline exonuclease. UL12 collaborates with the HSV single-strand DNA binding protein ICP8 to mediate recombination-dependent replication of viral DNA and is essential for the production of DNA th...

YvyrAI: A Spanish-First Recurrent-Deliberation Language Model Architecture with Internal Verification, Conditional Repair, and Adaptive Compute

We present YvyrAI, a Spanish-first decoder-only language model architecture centered on a recurrent module called the DeliberationBlock. A shared Transformer block is iterated within a single forward pass while a learned controller maintains a gated planning state, reads and writ...

Genome-Wide Association Identifies Candidate Genes for Salt Tolerance in Soybean at Emergence and Seedling Stages

Salt stress is an abiotic constraint on crop production, impairing growth while reducing yield and quality. As a source of edible oil and protein, soybean is particularly vulnerable to salt stress during emergence and seedling establishment, so the genetic basis of salt tolerance...

Bimodels and Biorthogonality for Abstract Machines

We develop a compositional semantics for abstract machines, focusing on CK/CEK machines for call-by-push-value. Taking abstract machines as the primary operational semantics, we introduce bimodels, which give denotations to both programs and stacks, and environment bimodels, whic...

Disentangling global supply chains: A systematic map of research on the biodiversity and social impacts of European blue food consumption

Abstract Background : Seafood is a vital global resource, yet the rapid growth of aquaculture – which now supplies over half the world’s blue food – has introduced significant ecological and social challenges. As a major importer and consumer, Europe is central to these global su...

Fatal invasive pulmonary aspergillosis caused by Aspergillus texensis: first documented human infection

<title>Abstract</title> Background Invasive Aspergillosis (IA) is a life-threatening infection in immunocompromised patients. Although <italic>Aspergillus fumigatus</italic> predominates, rare and cryptic species are increasingly recognized due to advances in molecular diagnostic...

Richardson–Gaudin states of non-zero seniority. III. The perfect-pairing limit

Strongly correlated electrons can be treated with a configuration interaction of Slater determinants grouped by their number of unpaired electrons with exponential cost. Papers I and II [P. A. Johnson, J. Chem. Phys. 162, 134106 (2025) and P. A. Johnson, J. Chem. Phys. 163, 08110...

MultipathwayAggregation Drives Concentration-DependentAmyloid Polymorphism and Time-Dependent Morphological Evolution

Abstract Amyloid aggregation into polymorphic fibrils is central to many neurodegenerative and systemic diseases, yet the physical origins of fibril polymorphism and time-dependent morphological evolution remain unclear. Because mature fibril morphologies are separated by high en...

Voluntary attention regulates acute immune responses in humans

<title>Abstract</title> Attention is a central mechanism for prioritizing and shaping sensory information. For example, directing attention away from injury reduces perceived pain. Whether such cognitive modulation extends to downstream biological processes has remained unknown....

Adaptive thermogenesis and fermentation as survival strategies of vegetative cells of Bacillus subtilis under simulated Martian stressors

<title>Abstract</title> Microbial responses to Mars‑analog environments are key to understanding the limits of life and improving life‑detection strategies. Here, we investigated the survival and physiological adaptation of <italic>Bacillus subtilis</italic> exposed for five sols...

Efficacy of Beta-Aminopropionitrile, Contractubex®, Nigella sativa Oil, Aloe Vera Oil, and Soybean Oil in Preventing Postoperative Adhesions in an Experimental Thyroidectomy Model

<title>Abstract</title> Background/Aim: Adhesions in reoperative thyroid surgery lead to prolonged operation times and an increase in postoperative complications. The use of anti-adhesive agents during the initial surgery may reduce the incidence of recurrent laryngeal nerve inju...

QUANTUM RESOLUTION TO-THE STATISTICAL-THERMODYNAMIC IN THE EXISTENCE OF LIFE

[Note: Translated with the assistance of Artificial Intelligence. Version 3 provides the full English translation of Version 2, which was originally written in Indonesian] This theoretical paper proposes a resolution to the apparent contradiction between classical statistical pro...

Host DNA repair factors empower a mechanism of antiviral nucleoside analog resistance

ABSTRACT How host functions affect resistance to antiviral drugs is poorly understood. Ganciclovir, a chain-terminating nucleoside analog, is a first-line therapy against human cytomegalovirus, a widespread herpesvirus that causes life-threatening disease in immunocompromised ind...

Behaviour of Reinforced Concrete Structures Resting on Soil Classes C and D under Repeated Earthquakes

This paper presents a thorough study of inelastic displacement ratios (IDR) of single degree of freedom (SDOF) systems under repeated earthquake loading by accounting for soil–structure interaction (SSI) and system’s degradation. Even though, there have been much research on impa...

Simulating exciton transport with complex absorbing potentials

We introduce a stochastic framework based on complex absorbing potentials (CAPs) to investigate exciton transport in large molecular aggregates. Within this framework, CAPs act as non-Hermitian reservoirs and sinks, enabling an effective assessment of transport efficiency. We app...

An annotated checklist and species accounts of the native terrestrial reptiles of the Turks and Caicos Islands

The Turks and Caicos Islands (TCI), an archipelago of more than 200 islands and islets at the southeastern terminus of the Lucayan Archipelago, support a native terrestrial reptile fauna of 11 species representing eight families. Of these, eight species are endemic to the TCI, an...

Unified Theory of Evolutionary Superfluid Cosmology: Integrating Hydrodynamic Gravity, Parameter Inheritance, and Temporal Inversion

Modern cosmology faces a dual crisis: the structural breakdown of geometric General Relativity (highlighted by "impossible" early galaxies observed by the JWST) and the philosophical dead end of the Anthropic Principle regarding the fine-tuning of the universe's 26 fundamental co...

Performance advantages of attached-flow conditions over well-timed leading-edge vortices in flapping-wing turbines

Flapping-wing turbines (FWTs) have shown competitive power extraction efficiencies relative to conventional rotary turbines, as demonstrated in literature with high-fidelity simulations and limited experiments on physical prototypes. It has become accepted wisdom in academic circ...

Cardiac monitoring and incidence of cardiotoxicity cardiomyopathy among breast cancer patients undergoing anthracycline regimen chemotherapy: insight from a single centre study

<title>Abstract</title> <bold>Background</bold> Anthracyclines remain a cornerstone of breast cancer therapy but carry a significant risk of cancer therapy-related cardiac dysfunction (CTRCD). This study evaluates the incidence of CTRCD in an Indonesian setting using the latest 2...

Influence of speech characteristics on working memory and perceived workload: Findings from experimental listening experiments

Exposure to background speech is known to impair working memory performance, a concern particularly relevant in open-plan office environments. This study aimed to examine how specific characteristics of speech, including semantic content and sound pressure level, affect cognitive...