Research works
The research papers we track — the newest first. Works with a plain-language summary link to it.
125030 work(s)
- Health & MedicineOpen access
Abstract Background Families play an important role in medical decision-making and end-of-life communication in the Chinese cultural context. However, existing evidence has largely focused on specific populations or individual family characteristics, and the combined contribution...
- BiologyOpen access
pH‐Driven Two‐Stage Conformational Switching Activates an Acid‐Responsive Chaperone
ABSTRACT Acidification rapidly denatures bacterial periplasmic proteins, yet this compartment lacks ATP‐dependent chaperones. We identify AchC as an acid‐responsive, ATP‐independent chaperone crucial for acid tolerance in Pseudomonas aeruginosa . As proton influx across the outer...
- AI & ComputingOpen access
Architectural Framework for a Positional Clock System
This work investigates the clock not as an instrument, but as a mathematical object. The foundation is the main theory p ≡ 1 (mod q). This theory has two forms. The theoretical form (q + 1 = p) is one round and m = 1. The actual form (2q + 1 = p) is two rounds and m = 2. The actu...
- Health & MedicineOpen access
Insight in schizophrenia is a crucial indicator of recovery; however, the "insight paradox" suggests that greater insight may be associated with poorer subjective outcomes. In this exploratory cross-sectional study, we aimed to classify Japanese inpatients with schizophrenia base...
- Engineering & TechnologyOpen access
Geometry-driven thermal–fluid topology optimization using B-spline geometric primitives
Topology optimization has been widely applied to thermal–fluid design, particularly for channel-based systems. However, many conventional approaches rely on implicit density-field representations, making it difficult to preserve geometrically interpretable channel features and di...
- Health & MedicineOpen access
Abstract Purpose To describe the Swedish Quality Registry for Rehabilitation in Visual Impairment (SKRS) and present rehabilitation measures and underlying diagnoses of visual impairment and blindness in adults in Sweden. Methods The study includes data from the SKRS collected be...
- Physics & SpaceOpen access
The ubiquity of coherent, microgauss-scale () magnetic fields across galaxy clusters, cosmic filaments, and pristine high-redshift systems presents an enduring conundrum in modern astrophysics. Standard cosmological magnetogenesis relies on the Biermann battery mechanism to gener...
- Society & EconomicsOpen access
As adolescents increasingly engage with social media, concerns have emerged about its potential implications for youth mental health and about disparities in digital experiences by sexual orientation (SO) and gender identity (GI). However, the mechanisms linking social media use...
- Engineering & TechnologyOpen access
It is widely acknowledged that proton exchange membrane electrolysis cells constitute the core technology for large-scale green hydrogen production from renewable energy sources. Hydrogen crossover in proton exchange membrane electrolysis cells poses critical safety and efficienc...
- Society & EconomicsOpen access
Although the Benishangul Gumuz Regional State (BGRS) has been implementing regional development plans for decades, it remains underdeveloped. This research aims to examine the status of regional development plan implementation and its determinant factors in Benishangul Gumuz, Eth...
- Health & MedicineOpen access
Probiotics for temporomandibular disorders: a critical appraisal of a therapeutic inference
Background and Objective: The gut-brain-jaw axis has been proposed as a systemic route contributing to trigeminal sensitisation in temporomandibular disorders. A therapeutic inference increasingly follows: that dysbiosis reduces short-chain fatty acid availability, and that probi...
- BiologyOpen access
Abstract The reward positivity (RewP) is an event-related brain potential (ERP) component associated with feedback and goal completion. Although the component is said to be generated in anterior cingulate cortex (ACC), this inference is disputed because of the inverse problem. Re...
- Climate & EnvironmentOpen access
This study provides the first baseline data on PAHs in the mangrove oyster Crassostrea gasar from contrasting production systems in two Brazilian Amazon conservation areas, including submerged aquaculture in Augusto Corrêa and aquaculture and intertidal natural banks in Curuçá. M...
- Health & MedicineOpen access
Enhancing bedaquiline solubility with advanced approaches for optimized tubercular therapy
The global resurgence of Mycobacterium tuberculosis strains exhibiting Extensive and Multidrug resistant tuberculosis (XDR and MDR-TB) is posing a strong challenge and burden on healthcare sector worldwide. The conventional first line and second line treatment options often showe...
- Physics & SpaceOpen access
E8 Phi‑Coupled Topological Protection of Quantum Microtubule States — E8 Intelligence Research
The 240 E8 root vectors, when phi‑scaled to the 132 Hz base frequency, form a quasi‑periodic hopping lattice that realizes a discrete analogue of a Su‑Schrieffer‑Heeger chain with phi‑encoded bond alternation. This structure supports topologically protected edge modes that lock m...
- Physics & SpaceOpen access
Multiple magnetic phases with tricritical phenomenon in the skyrmion host EuGa2Al2
Centrosymmetric skyrmion-hosting materials provide an excellent platform for exploring the interplay between topology and magnetism. Nevertheless, the underlying interaction mechanisms governing their complex phase transitions remain elusive. Here, we systematically investigate t...
- Society & EconomicsOpen access
Predictive Data Analytics for Early Detection of Hidden Business Risks Using Machine Learning
This research paper presents a machine learning-based framework for the early detection of hidden business risks using operational and financial data. Businesses generate large volumes of data related to sales, inventory, customer activity, payments, expenses, and operational sys...
- Health & MedicineOpen access
Abstract Neonatal hypoxic–ischemic encephalopathy (HIE) remains a leading cause of neonatal mortality and long-term neurodevelopmental disability. Although cranial ultrasound is widely used as a bedside screening tool, brain MRI has become central to diagnosis, injury pattern cla...
- Health & MedicineOpen access
DOPA-Based poly(ester amide)s−A Tunable Biomimetic Approach for Surgical Adhesive Design
Abstract Novel biomimetic surgical adhesives were prepared in this work by the straightforward incorporation of L-3,4-dihydroxyphenylalanine (DOPA) in poly(ester amide)s (PEAs). A library of DOPA-based PEAs (DOPA-PEAs) with varying compositions was successfully synthesized by sol...
- Health & MedicineOpen access
Alzheimer’s disease (AD) plasma biomarkers are cost-effective tools to detect early stage amyloid pathology. We investigated how interactions between AD genetic risk (apolipoprotein E (APOE) ε4, AD polygenic risk score (excluding APOE; PRSAD)), age, and sex affected AD plasma bio...