Research works
The research papers we track — the newest first. Works with a plain-language summary link to it.
134795 work(s)
- BiologyOpen access
A phase III clinical trial of PXT3003 in Chinese patients with Charcot-Marie-Tooth disease type 1A
Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited peripheral neuropathy and currently lacks disease-modifying therapy. PXT3003, a low-dose oral combination targeting PMP22 overexpression, has shown efficacy in two trials, while one recent confirmatory trial...
- Health & MedicineOpen access
BACKGROUND: Cardiovascular events are a leading cause of mortality after liver transplantation (LT), and existing risk scores incompletely capture myocardial vulnerability. OBJECTIVES: The objective of the study was to evaluate whether pre-LT myocardial strain improves machine-le...
- Health & MedicineOpen access
Hypertension in chronic kidney disease (CKD) is frequently resistant to pharmacologic therapy, with sympathetic overactivity contributing to both elevated blood pressure (BP) and renal disease progression. Renal denervation (RDN) targets renal sympathetic nerves and may provide d...
- Health & MedicineOpen access
Key messageNationwide Thai data showed that central precocious puberty (CPP) incidence rose sharply during the COVID-19 pandemic and plateaued, whereas premature thelarche (PT) continued to increase postpandemic, particularly among girls aged 7-8 years.Because progression from PT...
- BiologyOpen access
Seaweed fibers show promising effects on gut health, but it is unclear if processing of whole seaweed changes the nutrient accessibility for gut microbiota. This study investigated the effects of processed Saccharina latissima on the fecal microbiome composition and metabolic act...
- AI & ComputingOpen access
Terminator classification and singularity in the pn+1 family of maps
Summary of Research This paper presents a complete algebraic classification of "exact terminators" within the $pn+1$ family of maps, a generalization of the famous Collatz conjecture ($p=3$). An exact terminator is defined as an orbit value that collapses to 1 in a single contrac...
- Health & MedicineOpen access
The influence of epidural analgesia (EA) on the course of labour is still a matter of concern in modern obstetrics. Despite numerous studies have analysed labour progression, their findings are often inconsistent with regard to the effect of labour analgesia. In fact, women with...
- Climate & EnvironmentOpen access
The increasing frequency of wildfires under a changing climate has led to extensive ecosystem destruction, highlighting the need for reliable burned area assessment using satellite imagery. Single-satellite data are constrained by observation gaps and interference from smoke and...
- Health & MedicineOpen access
Muscle size matters: making paediatric vaccination safe for all - a pilot study
Background/objectives Shoulder Injury Related to Vaccine Administration (SIRVA) is an uncommon but clinically significant iatrogenic complication of vaccination, associated with improper injection depth or site selection. This pilot study aimed to evaluate the suitability of exis...
- Health & MedicineOpen access
The perception that individuals in crisis experience undue psychological burden by participation in research is a barrier to including surrogate decision-makers to critically ill patients in research studies. Importantly, perceptions from those who have engaged as surrogates are...
- Health & MedicineOpen access
BACKGROUND: Children with sickle cell disease (SCD) suffer from vaso-occlusive crises, extremely painful episodes that may require hospitalization. Traumatic experiences during hospitalization and frequent pain experiences may lead to psychological distress and the development of...
- Materials & EnergyOpen access
Vacuum drying is a critical process for the long-term integrity of spent nuclear fuel (SNF) storage. This study presents a systematic thermal-hydraulic evaluation comparing the conventional step-wise decompression method with a next-generation variable exhaust flow rate operation...
- Climate & EnvironmentOpen access
Fiji’s coastal communities are highly exposed to ocean waves that drive erosion, inundation and shoreline change. Yet the Fijian archipelago lacks a comprehensive, wave-climate assessment at a resolution that represents island effects appropriately. To address this gap, we presen...
- Materials & EnergyOpen access
The widespread use of silver nanoparticles (AgNPs) has led to their substantial release into aquatic ecosystems, yet their ecological risks within detritus-based food chains remain poorly understood. This study constructed a model detrital food chain— Pterocarya stenoptera leaf l...
- Biology
An Implantable Charge Balanced Neurostimulator IC Using Standard CMOS Process
This paper presents the design of a bipolar current-mode stimulator integrated circuit (IC) for implantable prosthetic devices using 0.18-μm standard CMOS process. The proposed stimulator IC is capable of delivering up to 1-mA current through 10-kΩ load using 12.8 V supply voltag...
- Engineering & TechnologyOpen access
This study evaluates the techno-economic feasibility of offshore wind-based ammonia production in 2035 and 2050. A pseudo-dynamic modeling framework with capacity optimization is applied to three offshore sites in Colombia, Denmark, and Spain using long-term wind data to capture...
- Health & MedicineOpen access
Atrial standstill (AS) is a rare arrhythmogenic disorder characterized by the complete absence of atrial electrical and mechanical activity, most commonly resulting from atrial fibrotic cardiomyopathy (AFC). Optimal management remains challenging, particularly when selecting an a...
- BiologyOpen access
Africa is facing more frequent and damaging climate hazards whose effects often interact across sectors, places, and time. This narrative review synthesizes evidence from 2023 to 2025 on socio-economic vulnerability and institutional responses to compounding climate hazards in Af...
- Physics & SpaceOpen access
This paper consolidates the Theory of NeoGravity and states its case. Its central demonstration is a convergence: three mathematically independent formalisms, Newtonian relativity mechanics, classical fluid dynamics, and Einstein's tensor calculus, are each carried through the cl...
- BiologyOpen access
Epigallocatechin-3-gallate (EGCG) is the most bioactive galloylated catechin in tea ( Camellia sinensis (L.) O. Kuntze) plants. Its biosynthesis is precisely regulated by transcription factors. In this study, we used the promoter of the CsSCPL11-IA gene, which encodes a key enzym...