Research works

Tissue and Cerebral Biofluid Remodelling of tRNA-Derived Small RNA Signatures in Experimental and Human Epilepsy

Small noncoding RNAs are increasingly recognized as important regulators of gene expression in brain diseases including epilepsy. tRNA-derived small RNAs (tsRNAs) including tRNA fragments (tRFs) and tRNA halves (tiRNAs) are emerging as stable and regulated RNA species which respo...

Hidden Malignancy: Predominantly In Situ Porocarcinoma Arising in a Poroma

ABSTRACT: Porocarcinoma is a rare malignant adnexal tumor which can originate either de novo or-much more rarely-from a preexisting eccrine poroma. Given its aggressive clinical behavior, a timely diagnosis is essential for optimal patient's management. We report the case of a 79...

The Universal Information Lattice: An Informational Topology Framework for Scale-Invariant Morphogenesis, Multifractal Criticality, and Non-Linear Temporal Trajectories

This preprint introduces the Universal Information Lattice (UIL), a synthetic informational topology framework postulating that four-dimensional spacetime and physical mass distribution are emergent phenomena generated by a sub-quantum thermodynamic matrix. By integrating princip...

Dual-Axis Knowledge Assessment: Epistemic Stability and Effectiveness Domain

Generative AI has sharply reduced the cost of producing and disseminating knowledge, forcing knowledge assessment to separate two questions: how reliable is the knowledge claim itself, and does it take effect for this user on this task channel? We propose a two-axis framework. Th...

Transcription factor CCA1 interacts with RGL1 to regulate flowering in Arabidopsis

Flowering time is regulated by both external environmental cues and internal factors. CCA1(CIRCADIAN CLOCK ASSOCIATED 1) is a core component of the plant circadian clock. While previous studies have implicated CCA1 in flowering regulation, its underlying mechanism has remained in...

Lower Cambrian carbonate microfacies and depositional environments on Yorke Peninsula, western Stansbury Basin, South Australia

The western Stansbury Basin is a largely subsurface early–middle Cambrian sedimentary succession centred on Yorke Peninsula, South Australia. The oldest carbonate units include the pervasively dolomitised Kulpara Formation, and the unconformably overlying nodular and bioclastic P...

DCRT: Depth-confidence-guided complementary residual temporal adapter for camera-based BEV 3D object detection

Abstract Camera-based bird's-eye-view (BEV) 3D object detection is important for autonomous-driving perception, but the quality of BEV representations is easily affected by depth-estimation errors, object motion, and cross-frame alignment errors. Existing temporal BEV detection m...

Targeting PKM2 Enhances the Anti-Tumor Function of CD8+ T Cells Through Metabolic Reprogramming

The efficacy of adoptive cell transfer (ACT) therapy in solid tumors is often limited by the functional exhaustion and insufficient persistence of infused CD8+ T cells within the tumor microenvironment. Through the integrated analysis of single-cell transcriptomic data, this stud...

Constructing Resistance: Socially Engaged Architecture and Civic Activism in Croatia

Abstract This article traces the emergence of socially engaged architectural practices in Croatia within wider civic mobilizations against investor-driven urbanism and contested spatial governance. It examines how architects, acting as civic experts, navigated post-socialist urba...

Ancient Math's Harmonic Cosmos: Carlson's Dense Lecture — E8 Intelligence Research

FINDING: The corpus of documentaries collectively confirms that ancient Babylonian and Egyptian mathematics operated on a sexagesimal (base-60) positional system with reciprocal tables, and that Greek mathematics formalized Euclidean geometry — but the single most mathematically...

Occupational Hazards, Injuries, and Health Outcomes Among Water and Wastewater Workers: A Systematic Review

Water and wastewater workers encounter complex occupational exposures, but evidence on related injuries and adverse health outcomes remains fragmented. We systematically searched PubMed/MEDLINE, Scopus, Web of Science Core Collection, and Embase on 23 April 2026 and synthesized e...

Lipid nanoparticle-based drug delivery for invasive fungal infections: engineering strategies, therapeutic advances, clinical translation, and future perspectives

Invasive fungal infections (IFIs) remain a major cause of morbidity and mortality among immunocompromised patients despite the availability of multiple antifungal agents. Their clinical management is frequently limited by poor aqueous solubility, inadequate tissue penetration, sy...

Regional Stabilization Before Transfer in Moderate Traumatic Brain Injury: Comparable Outcomes Within a Rural Hub-and-Spoke Trauma System

Background The Brain Trauma Foundation’s guidelines specifically highlight the need to determine optimal triage destination for moderate traumatic brain injury (modTBI) patients, particularly in rural settings where Level I trauma centers may be geographically distant. Methods Re...

Brain calcification‐associated JAM2 pathogenic mutations impair JAM2 – JAM3 tight junction structure and the blood–brain barrier integrity

Abstract Primary brain calcification (PBC) is a neurodegenerative disorder characterized by bilateral brain calcification. JAM2 is a PBC causative gene, encoding the tight junction protein JAM2 and critical for blood–brain barrier (BBB) integrity, with an uncertain pathogenic mec...

Exosome-packaged ILK from healthy female serum stimulate osteogenesis via the MAPK signaling pathway

The pathogenesis of osteoporosis (OP) is multifactorial, with impaired osteogenic differentiation of bone marrow stromal cells (BMSCs) serving as a fundamental pathological basis. Enhancing osteogenesis is a key strategy for OP therapy. Exosomes are recognized as promising cell-f...

The gentrification of mentorship: How influencers are re-shaping prestige in platform-driven academia

This conceptual paper explores how platform society influences academic prestige. It argues that mentorship, traditionally rooted in the relationship between a professor and a student, is becoming commercialised. This commercialisation turns mentorship into engaging performances...

Systematic Review and Meta-Analysis of Lipid Emulsion for Non-Local Anesthetic Poisoning

Abstract Introduction Practitioners routinely use intravenous lipid emulsion for local anesthetic systemic toxicity, but its role in non-local anesthetic poisonings remains unclear. We conducted a systematic review and meta-analysis comparing lipid emulsion with standard care for...

A Condition-Disentangled Representation Optimization Framework for Domain Generalization Under Distribution Shift: Application to Fault Diagnosis

Domain generalization under distribution shift remains a fundamental challenge in representation learning, where predictive models trained on multiple source domains are expected to generalize to previously unseen operating conditions. For rotating machinery fault diagnosis, vari...

Cumulative surgeon volume is associated with improved outcomes following hip arthroscopy: A national registry study

Abstract Purpose This study assessed the association between (1) annual and (2) cumulative surgeon volume and patient‐reported outcome measures (PROMS) after hip arthroscopic surgery for femoroacetabular impingement syndrome (FAIS) using data from the UK Nonarthroplasty hip regis...

Slãgănəž : The community argot of the Kawəltīn of Annaba (Algeria)

This article presents Slãgănəž, an argot whose matrix is the Arabic dialect of the city of Annaba in Algeria and which is practiced mainly within the local gender and sexuality minority community known as əl-Kawəltīn. I will provide initial information on how this slang functions...