Research works

Epigenetic reprogramming in SCNT embryos: from inefficient remodeling to precision enhancement

Somatic cell nuclear transfer (SCNT) is a unique reproductive engineering technique capable of conferring totipotency onto a somatic cell genome. It holds significant promise for animal germplasm conservation, livestock industry advancement, and biomedical research. Despite succe...

Scientific Clinical Trial Publication Productivity in Medical Oncology: A Comparative Analysis and Data Review of Northern and Southern Italy

Background: Italy exhibits a socioeconomic divide between its northern and southern regions, which extends into healthcare delivery and biomedical research. Medical oncology is particularly affected by this structural imbalance. This paper examines geographic disparities in clini...

Dibutyl phthalate disrupts ESR1-GPX4 redox signaling and aggravates ovarian dysfunction in a PCOS-like mouse model

Dibutyl phthalate (DBP), a widely used phthalate plasticizer, has been implicated in reproductive toxicity, but the molecular mechanisms by which experimental DBP exposure affects ovarian granulosa-cell function remain incompletely defined. In an exploratory clinical cohort, urin...

Reproducibility Package for Numerical and Formal Diagnostics of a Compactly Supported Bombieri–Weil Positivity Test

Description This repository contains the source code, numerical data, figures, interactive HTML report, analytic tail estimates, and Coq formalization accompanying the development-stage preprint Numerical and Formal Diagnostics for a Compactly Supported Bombieri–Weil Positivity T...

Eriobotrya japonica (Loquat) Leaf Extract: An Integral In Vitro and In Ovo Approach to Antimelanoma Potential and Safety

Melanoma continues to be one of the most challenging diseases in oncology, given its aggressiveness and increased resistance to existing therapies. Therefore, the identification of novel therapeutic strategies is of considerable interest, with medicinal plants representing a prom...

Mass-balance interpretation of erosion–oxidation degradation in NiCr-based thermal spray coatings under fly ash impingement at 600 °C

High-temperature degradation of protective thermal-spray coatings under fly ash impingement is governed by coupled oxidation, deposition, and erosion-assisted material removal. Consequently, transient mass change does not necessarily represent post-cleaning residual degradation b...

Distinction, Perspective, and Predictive Closure: Complete Research Release 8.0.2

I present a cumulative research programme on distinction, perspective, predictive closure, representation genesis, quantum instruments, prime arity, and recurrence. This complete release brings together eighteen specialist papers and one scientific atlas as a two-hundred-page res...

Immune Checkpoint Inhibitor–Associated Acute Kidney Injury

Immune checkpoint inhibitors (ICIs) have reshaped modern oncology by improving outcomes in multiple cancers. They function by enhancing T-cell–mediated antitumor immunity through the blockade of inhibitory pathways, such as cytotoxic T-lymphocyte–associated protein 4 (CTLA-4), th...

Capitalization Bus Theory (CBT) V3.54: Time, Cash Flows, Discount Rates, and Boundaries from a Human-Centric Perspective

Abstract (English) Capitalization Bus Theory (CBT) V3.54 presents a human-centric analytical framework for translating economic and social phenomena into Free Cash Flow (FCF), discount-rate structures (r-structure), Property Rights & Boundaries, and Buses. It begins from three ax...

A New Sustainable Approach to Antibiotic Resistance: Development of bis‐Quaternary Ammonium Salts From 2,4,6‐Trichloro‐1,3,5‐Triazine

The development of highly effective antibiotics and antimicrobials over the centuries has greatly improved human life. However, the irresponsible use of these substances and their release into the environment have led to the emergence of resistant microorganisms. Quaternary ammon...

EXTRACTED METHOD: phi_ratio_audit — E8 Intelligence Research

rule: For each polygonal joint, compute all internal angle ratios; flag any within ±0.5% of phi, 1/phi, or phi^2; compare to Monte Carlo baseline of random polygons. source: rlab #196 Author: Andrew Stewart Caldin, Independent Researcher, UK. Part of the E8 Intelligence Research...

Climate change and households’ vulnerability in Sidama Regional state, Ethiopia

Abstract Climate change significantly threatens rural households in Ethiopia, particularly regarding increased climatic variability and livelihood vulnerabilities. This study, based on a survey of 440 households and supplemented by 30 years of climate data in the Sidama Regional...

Marine chitinase BtChi disrupts cell wall integrity in Candida albicans and non-albicans species by chitin targeting and release of chitooligosaccharides

Abstract Increasing resistance to conventional antifungal drugs against Candida species, along with the limited availability of drug targets due to similarities between fungal and human cellular processes, necessitates alternative antifungal strategies. Chitin, a key polysacchari...

The use of Galleria mellonella to study microbial interactions, immune responses, and substrate interactions

Interbacterial interactions are diverse and complex and often dependent on the given niche these bacteria inhabit; therefore, it is often necessary to validate in vitro findings in vivo. Multiple mammalian in vivo models have been established for this purpose, from mice to larger...

Combined effects of thermal processing and spice bioactive compounds on the reduction of aflatoxins in paprika

Aflatoxins are potent mycotoxins frequently detected in paprika, posing significant food safety concerns. This study evaluated the effect of a Moroccan spice blend combined with thermal processing on aflatoxin reduction in naturally contaminated sweet paprika. The spice blend, co...

EuroMillions Breakthrough Mining — 2917 Sources, 24740 Leads Extracted — E8 Intelligence Research

Mined 2917 lottery+quantum breakthroughs. Extracted 24740 leads across 13 categories. 22447 high-value leads found. Categories: {"CORRIDOR": 2098, "FORMULA": 1933, "GEOMETRIC": 879, "FORWARD_ATTEMPT": 2228, "QUANTUM": 2441, "TIMING": 267, "CELESTIAL": 2020, "GEMATRIA": 2125, "CON...

Gaps in Breast Reconstruction Patient Educational Resources: Comparing Patient and Surgeon Perspectives

Abstract Breast reconstruction is an important component of cancer care following mastectomy, improving psychosocial well-being and quality of life. However, not all patients are satisfied with their outcomes. Patient satisfaction with preoperative information is a strong predict...

Human resources training and development, value creation, and employee performance in the public service

This study examines the relationship between human resource training and development (HRTD), involving training (HRT) and employee development (EMD), and employee performance in Uganda’s public service, focusing on the mediating role of human resource value creation (HRVC), compr...

Can leaders’ and teams’ expectations encourage creative performance? A multilevel mediation study

To cultivate creative graduates capable of adaptability and critical thinking, understanding how social contexts shape creative performance is essential. However, limited empirical research addresses how expectations from multiple social levels simultaneously drive creative outco...

EXPLORING THE ANTIFUNGAL POTENTIAL OF MEDICINAL PLANTS: A REVIEW

ABSTRACTThe problem of fungal infections is becoming more significant in global health because of theirincreased prevalence, high morbidity, development of resistance to antifungals, fewer treatmentalternatives, and presence in immunocompromised patients. This review is focused o...