Research works

HERBAL THERAPIES IN FIBROMYALGIA: A REVIEW OF CURRENT EVIDENCE

Fibromyalgia (FM) is a chronic disorder characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, cognitive dysfunction, and psychological symptoms such as anxiety and depression. It significantly affects the quality of life of patients and poses a major chal...

ORTHOBIOLOGIC AND ROBOTIC INNOVATIONS FOR TENDON-TO-BONE HEALING IN CHRONIC ROTATOR CUFF TEARS

Chronic rotator cuff tears are a clinical challenge due to chronic inflammation, progressive tendon degeneration, impairment in regeneration and fatty infiltration. High retear rates, particularly in chronic and large tears, highlight the limitations of mechanical repair alone. T...

STRENGTHENING HEALTH SECURITY THROUGH INTELLIGENT RISK DETECTION SYSTEMS IN PUBLIC HEALTHCARE SETTINGS

Background: Strengthening health security requires effective strategies for identifying and managing public health risks. As one of the most prevalent oral diseases globally, dental caries represents a significant burden on healthcare systems and serves as a key indicator of comm...

ROLE OF VATA DOSHA AND DHATU KSHAYA IN THE PATHOGENESIS OF JANUSANDHIGATA VATA: A CONTEMPORARY PERSPECTIVE

Background: Janusandhigata Vata is an important Vata-dominant disorder affecting the knee joint and is clinically characterized by pain, swelling, crepitus and restriction of joint movements. Its clinical manifestations demonstrate substantial overlap with knee osteoarthritis (KO...

PREDICTORS OF PROLONGED HOSPITAL STAY AMONG CHILDREN WITH ACUTE GASTROENTERITIS

Background: Acute gastroenteritis is one of the most common causes of morbidity and hospital admission among children. Although most cases respond to appropriate rehydration and supportive treatment, some children require prolonged hospitalization, resulting in increased healthca...

A CASE STUDY ON ROPANIYA KARMA OF KAMPILLAKA TAILA ON NON HEALING ULCER

A non healing ulcer is a sore or wound on the skin or mucous membrane that fails to heal within normal time frame despite treatment. They may be due to poor blood supply, diabetes, infection, chronic pressure, venous insufficiency, poor nutrition.[1] According to Ayurveda Non Hea...

LITERATURE REVIEW ON THE MANAGEMENT OF KADARA WITH SPECIAL REFERENCE TO CORN

Kadara is a common disorder described in Ayurvedic literature under Kṣhudra Rogas. It is characterized by a hard, painful, nail-like growth occurring predominantly on the plantar surface of the foot due to repeated pressure, friction, trauma, or improper walking habits. Clinicall...

CONCEPTUAL EVALUATION OF BHAISHJYAKAALA IN THE TREATMENT OF SAPTA DHATU DUSHTI

Introduction: Bhaishjyakaala denotes the appropriate time of drug administration and is considered an important factor influencing therapeutic efficacy in Ayurveda. Its selection depends on the relation of medicine to food, the status of digestion, Dosha predominance and the func...

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF ROPIVACAINE: A REVIEW OF UV AND HPLC TECHNIQUES

Ropivacaine hydrochloride is a widely used long-acting local anesthetic that requires reliable analytical methods to ensure its quality, safety, and therapeutic efficacy. Numerous analytical techniques have been reported for its quantitative determination, among which UV spectrop...

NANOPARTICLE-ENABLED TRANSDERMAL DELIVERY OF CANNABIDIOL AND RELATED CANNABINOIDS: CARRIER CHEMISTRY, QUALITY-BY-DESIGN FORMULATION, AND THERAPEUTIC TRANSLATION

Cannabidiol (CBD) and related phytocannabinoids have attracted sustained pharmaceutical interest for their anti-inflammatory, analgesic and antioxidant properties, yet their clinical utility is persistently constrained by negligible aqueous solubility, extensive hepatic first-pas...

PREVALENCE OF MECHANICAL NECK PAIN AND ITS ASSOCIATION WITH SMARTPHONE USE, SMARTPHONE ADDICTION, NECK DISABILITY, AND CERVICAL RANGE OF MOTION AMONG UNIVERSITY STUDENTS: A CROSS-SECTIONAL STUDY

Background: Smartphones have become an essential part of university students' daily lives, supporting academic work, communication, entertainment, and social interaction. Extended smartphone use often encourages prolonged neck flexion and poor postural habits, increasing mechanic...

CONCEPTUAL UNDERSTANDING AND CONTEMPORARY RELEVANCE OF VISA SANKATA - A CRITICAL REVIEW

Viṣa Saṅkaṭa is a classical concept of Ayurvedic toxicology describing a critical prognostic state in which multiple host, environmental, dietary, doṣic, and tissue-related factors converge to intensify toxicity and produce a potentially fatal systemic crisis. This article explor...

FORMULATION AND EVALUATION OF POLYHERBAL ANTI-ACNE GEL.

Acne vulgaris is a common inflammatory skin disorder associated with excessive sebum production, follicular hyperkeratinization, bacterial colonization, and inflammation. In this study, extracts from Bombax ceiba, Butea monosperma, Rubia cordifolia, Morus alba, and Glycyrrhiza gl...

AGNIKARMA AS A PARA-SURGICAL PROCEDURE ALONG WITH TRAYODASHANGA GUGGULU IN THE MANAGEMENT OF GRIDHRASI- A SINGLE CASE STUDY

Background: Gridhrasi, a Vata-dominant Nanatmaja Vyadhi characterized by radiating pain from the buttock to the lower limb, closely resembles sciatica in modern medicine. Among various Ayurvedic interventions, Agnikarma (therapeutic cauterization) as a para-surgical measure and T...

EXPLORING THE HEALTH EFFECTS OF DRUG INDUCED GUT MICROBIAL CHANGES: IMPLICATIONS FOR PERSONALISED MEDICINE

The human gut microbiome, comprising over 100 trillion microorganisms, plays a crucial role in maintaining health by influencing immunity, nutrient absorption, and defence against pathogens. Growing evidence highlights how various medications, both antibiotic and non-antibiotic,...

A COMPREHENSIVE REVIEW ON THE PHYTOCHEMISTRY, ETHNOPHARMACOLOGY, AND PHARMACOLOGICAL POTENTIAL OF EVOLVULUS NUMMULARIUS

Evolvulus nummularius (L.) A perennial, creeping herb, L. is a member of the family Convolvulaceae and is widely distributed throughout tropical and subtropical areas. It has been traditionally used for the treatment of wounds, inflammation, fever, gastrointestinal disorders, ski...

DESIGN, SYNTHESIS, AND ANTIMICROBIAL EVALUATION OF NOVEL ISATIN–MOXIFLOXACIN-BASED 1,2,3-TRIAZOLE DERIVATIVES

The increasing emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis has created an urgent need for the development of new antimycobacterial agents with improved efficacy. In the present study, a series of six novel isatin–moxiflox...

BEYOND THE TABLET: ORAL THIN FILMS AS A PLATFORM FOR PATIENT-CENTRIC, 3D-PRINTED DRUG DELIVERY

Oral thin films (OTFs) are flexible drug delivery systems that disintegrate or dissolve quickly in the oral cavity and are convenient to use, without the need for water. The ease of administration and quick onset of drug release, as well as the possibility to enhance patient adhe...

THE CELLULAR GLYCOCALYX AND ITS BIOPHYSICAL AND BIOMOLECULAR BEHAVIOURAL ASPECTS

Biological cell is a basic dynamic structural and functional entity of a living being. Their molecular make-up exhibits varied physicochemical and molecular functional complexities. These lead to the effective manipulation of their overall behaviour and ensure their survival in s...

EFFECT OF NATURAL POLYPHENOL EXTRACTS ON HIGH-FRUCTOSE-INDUCED METABOLIC DYSREGULATION

High-fructose consumption has been implicated in the development of metabolic disorders characterized by obesity, insulin resistance, dyslipidemia, oxidative stress, inflammation, and hepatic dysfunction. This study evaluated the protective effects of natural polyphenol extracts...