Research works

Lynch syndrome–associated urothelial carcinoma: clinical and molecular findings from a single-institution cohort

Lynch syndrome–associated urothelial carcinoma (LS-UC) is a rare and undercharacterized clinical entity. While FGFR3 alterations are well described in sporadic urothelial carcinoma, their prevalence and clinical implications in LS-UC remain unclear. We aimed to provide a comprehe...

Gender and STEM: academic over-selection and stratified university entry

Background Gender disparities in STEM participation remain one of the most persistent forms of horizontal segregation in higher education. While prior research has predominantly emphasised individual-level determinants such as interests, self-efficacy or vocational orientations,...

Synthesis of morphologically different SnHPO 4 using a refluxing method

This work presents a simple and efficient reflux method for the synthesis of Tin(II) hydrogen phosphate (SnHPO4). This method is faster and requires less instrumentation. The reported methods use highly hygroscopic SnCl2 as the starting material, whereas the current method uses m...

The meaning of ‘normal’ – children’s negotiation of (normal) masculinity, femininity, and LGBTQ media representations in Flanders

This study examines how 55 children (aged 10–12) in Flanders interpret LGBTQ media representations and negotiate related norms of gender and sexuality. Drawing on twelve focus groups across four different schools, the research investigates the dynamics of their peer interactions,...

Digital maturity and financial balance: a deep analysis of performance management in Hungarian E-commerce enterprises from 2019 to 2023

This research examines performance measurement practices and financial effectiveness in Hungarian e-commerce from 2019 to 2023, addressing how inconsistent decision-support systems challenge sustainable profitability. Conducted across a structured multi-phase research timeline (2...

Aging while caregiving: a life course qualitative study of left-behind older parents caring for adult children with schizophrenia in rural China

Older adults left behind in rural areas due to large-scale migration often serve as the primary caregivers for their adult children with schizophrenia. This study explores their long-term caregiving experiences, focusing on how caregiving responsibilities are distributed within f...

Regulation in ecological systems: an organizational approach

The term “regulation” is often used in biology to refer to the means by which a system keeps or returns to a certain state after perturbation. Feedback mechanisms and the propagation of the perturbation through a network of constitutive components are commonly associated with thi...

A comparative study of turbulence models in a trapezoidal open channel for potential turbine installation site selection

With large-scale projects being installed all over the world, the hydrokinetic (HK) sector has been considered as zero-head power scheme. When site conditions are adequate but ideal velocities are unavailable, choosing an installation location might be challenging. For identifyin...

Antibody framework engineering enables augmented cytokine receptor signaling capacities of bispecific single domain antibody-based IL-21 mimetics

In this work, we developed bispecific antibody (bsAb)-derived surrogate agonists which mimic the function of IL-21 by targeting the IL-21 receptor composed of IL-21 R (CD360) and IL-2 Rγ (CD132). For this, antigen-specific VHHs (variable domains of the heavy chain of heavy-chain-...

Simultaneous Measurement of Total and Occupied/Free PD-1 on a Single Cell by Mass Cytometry: Development of a Novel Method for Receptor Occupancy Assessment

Receptor occupancy (RO) assays are often used to quantify and characterize the binding profiles of antibody-based therapeutic drugs to target receptors, providing valuable pharmacodynamic insights. Programmed cell death protein 1 (PD-1) is a key immune checkpoint that suppresses...

Informal support as a mediator between material hardship and stress for parents involved with the child welfare system

Families often turn to informal support for help but for families involved with the child welfare system, these networks may be strained, unavailable, or inconsistent. This study tested the extent to which informal support mediated the relationship between material hardship and s...

Tail convergence in insurance financial protection: multi-layer performance among hospitalised NCD patients in Southwest China

Introduction China’s multi-layer health insurance system provides financial protection through basic insurance (Urban Employee Basic Medical Insurance [UEBMI] and Urban-Rural Resident Basic Medical Insurance [URRBMI]), catastrophic supplemental coverage, and medical assistance. U...

Global burden of varicella in children aged 5–9 y, relationship with vaccination policy indicators, and projected trends to 2030

Varicella remains a common childhood infection worldwide. Understanding long-term trends and identifying key determinants of disease burden are essential for informing vaccination strategies and public health planning. Data were obtained from the Global Burden of Disease (GBD) 20...

Autonomy in Prison: Street-Level Bureaucrats Re-Connecting with Their Purpose

Policy alienation research highlights how public professionals experience powerlessness and meaninglessness when policies misalign with their professional values and work context. While previous research conceptualizes policy alienation as a largely static condition, this article...

Differentiating Pure and Mixed Mucinous Breast Carcinoma Using Multimodality Imaging: A Retrospective Single-Center Study

Objective: This study aimed to evaluate the efficacy of mammography, ultrasound, and magnetic resonance imaging (MRI) features in differentiating pure from mixed mucinous breast carcinoma and in identifying imaging characteristics specific to each subtype. Methods: This retrospec...

Copper(II)/TBHP-mediated oxidation of isoindolinones and other substrates—effect of air and oxygen

When employed in conjunction with tert-butyl hydroperoxide (TBHP), iron(III) and copper(II)-catalyzed oxidation systems have proven to be effective in transforming isoindolinones to the corresponding phthalimides. Considering both metal-mediated processes, one of the issues that...

Impossible practices: on the ideology of codesign

Codesign is widely framed as a democratic and inclusive practice, particularly in development-sector contexts where it is invoked as a way of ensuring that those affected by design have a voice in shaping decisions that concern them. Yet designers frequently encounter tensions be...

Shut Your Eyes in the Dark! Differential Effects of Pre-Bedtime and Pre-Shuteye Media Use on Sleep Delay and Anxiety

The pervasive use of digital media before sleep is increasingly recognized as a critical factor affecting sleep and psychological well-being. However, the impact of bedtime media at different stages-specifically, before bedtime and before shuteye-remains unclear. Using data from...

Perspectives of staff and administrators on active aging among older inpatients: a qualitative descriptive study of an Ontario hospital

Older adults in Canadian hospitals often experience prolonged stays, leading to high volumes of sedentary time and social isolation, both of which negatively impact recovery. This qualitative descriptive study explored how healthcare workers and hospital leadership perceive these...

Secure network forensic investigation framework with elliptic curve cryptography-based encryption and enhanced message digest integrity verification

Forensic evidence can be easily altered or disclosed to those who are not authorized, which reduces the evidence integrity, reliability, and admissibility in cyber forensic investigation. Current forensic approaches are mostly concerned with evidence collection and analysis, and...