Research works

Genetic risk and telomere dynamics in chronic kidney disease associated with mitochondrial dysfunction and implications for Coenzyme Q10 therapy

Chronic kidney disease (CKD) is a major global health burden characterized by progressive loss of renal function and an increased risk of cardiovascular morbidity and mortality. The risk of adverse outcomes rises with declining glomerular filtration rate, with cardiovascular dise...

Community institution utilization and awareness of elderly welfare services: The moderating role of information-use difficulties

This study aimed to examine whether difficulties in information use were associated with differences in awareness of social welfare services, even among older adults who were exposed to service-related information through institutional contacts. This study utilized data from the...

The charm of fashion: value co-creation in fashion production and consumption at heritage tourism destinations

The role of fashion in cultural heritage tourism has attracted increasing attention from both practitioners and scholars. However, robust theoretical explanations of how heritage tourism destinations participate in the production and consumption of fashion remain limited. Drawing...

Difficult-to-treat systemic lupus erythematosus: from refractory disease to a multidimensional clinical trajectory

Difficult-to-treat (D2T) systemic lupus erythematosus (SLE) is increasingly recognised in clinical practice but is still conceptually underdeveloped. In contrast to rheumatoid arthritis and psoriatic arthritis, for which formal D2T frameworks have been proposed, SLE still lacks a...

Study on the steady-state operation characteristics of open loop heat pipe desalination

Open loop heat pipe desalination (OHLPD) can achieve a high water production rate with a small temperature difference, without consuming additional mechanical power. In this study, a steady-state model of the OLHPD system was established to investigate its water-production perfor...

Integrating Azotobacter inoculation with nano-NPK foliar application: a sustainable strategy for enhancing growth, physiology, and sugar yield in sugar beet (Beta vulgaris L.)

Sugar beet is a key crop for the sugar industry, increasingly reliant on eco-friendly inputs to meet rising global demand. Plant growth-promoting rhizobacteria (PGPR) enhance plant growth via root associations, while nanotechnology offers solutions to limitations of traditional f...

Engineering and characterization of a novel hydrogel-based cancer spheroid system to recapitulate clinical wIRA -hyperthermia treatments

Background Water-filtered infrared-A (wIRA) mild hyperthermia (mHT) combined with radiotherapy can effectively treat superficial tumors. While in vitro models are essential for mechanistic studies, existing approaches mostly rely on monolayer cultures and non-clinical heating. We...

Association between insomnia symptoms and social frailty in community-dwelling adults aged 75 years and older: a cross-sectional study

Insomnia has been associated with frailty; however, its association with social frailty remains unclear, particularly among adults aged 75 years and older. This study aimed to examine the association between insomnia symptoms and social frailty in community-dwelling adults aged 7...

Complete mitogenome of Plagiognathops microlepis and its phylogenetic position within the subfamily Xenocyprinae (Cypriniformes: Cyprinidae)

The complete mitochondrial genome of Plagiognathops microlepis was sequenced using Illumina NovaSeq and PacBio Sequel II platforms.The circular mitogenome is 16,632 bp in length and contains 37 genes: 13 protein-coding genes (PCGs), 22 transfer RNA (tRNA) genes, 2 ribosomal RNA (...

Impaired amyloid-beta uptake and distinct transcriptomic profiles of monocytes in APOE4 carriers: The Chongqing Ageing and Dementia Study

The ε4 allele of the apolipoprotein E gene (APOE4) is the strongest genetic risk factor for sporadic Alzheimer’s disease (AD). However, its impact on monocyte-mediated amyloid-β (Aβ) clearance and associated immune dysfunction remains poorly understood. Through Aβ uptake assays i...

Catalytic and computational strategies for removing ECs from agricultural water systems

Emerging contaminants (ECs), including pharmaceuticals, pesticides, endocrine-disrupting compounds, and personal care products, have become increasingly prevalent in agricultural water systems due to intensified agricultural activities and expanding chemical usage. Their persiste...

Pushing the boundaries of virtual screening scale of combinatorial spaces with the V-SYNTHES approach

Computational screening of giga-scale chemical spaces opens a cost-effective path to high-quality hit identification, providing entry points for drug discovery. As these on-demand spaces grow and successful applications multiply, rigorous blind benchmarks like CACHE Challenges pr...

Exercise Training in PAH: Methodological Ingenuity Meets Ethical Complexity

Nicola Benjamin, Ekkehard Grünig; Exercise Training in PAH: Methodological Ingenuity Meets Ethical Complexity, Annals of the American Thoracic Society, , a

Unlocking the ecological dividend of green innovation: the dual moderating effects of institutional constraints and structural enablers

Green technology innovation possesses the dual attributes of environmental protection and economic development, making it an important pathway for achieving the ‘dual carbon’ goals and supporting ecological civilisation construction and sustainable urban development. Using 2006–2...

Iliopsoas abscess in crohn’s disease: systematic review of case reports and case series

Transmural inflammation is a hallmark of Crohn’s disease (CD), a chronic inflammatory bowel disease that exposes patients to serious consequences such as fistulas and abscesses. Iliopsoas abscess (IPA) is an uncommon but potentially fatal penetrating (extra-luminal) complication...

Microdroplet-based high-throughput screening for antagonistic bacteria targeting penaeid shrimp pathogenic Vibrio harveyi

Antagonistic bacteria that suppress the growth of specific bacteria have attracted attention as an antibiotics-independent strategy for infectious disease control in aquaculture. Microfluidics-based water-in-oil droplets (microdroplets) enable high-throughput screening of antagon...

Giardia: everything you need to know about the parasite on the rise

Cases of giardiasis have reached a 10 year high in England. The BMJ looks at why this has happened and what doctors and patients need to know

Jurisprudential evolution and the protection of Indigenous collective property rights in ASEAN: international standards, national divergence and institutional capacity

This article examines why the protection of indigenous collective property rights diverges across Indonesia, the Philippines, Malaysia, and Cambodia despite common international standards. comparing constitutional recognition, statutory tenure, judicial remedies, and administrati...

Recovery of AA7075 alloy and TiC-rich powder from laboratory-generated unusable AA7075/12 wt.% TiC composite using Box–Behnken design

This study investigates the recovery of AA7075 alloy and pre-existing in situ-formed TiC reinforcement from laboratory-generated, unusable AA7075/12 wt.%TiC metal matrix composite scrap. Controlled remelting experiments were designed using 17-run Box–Behnken design, and the effec...

Differences in bioactive compounds between red cabbage grown as microgreens or to mature plants under organic conditions

There is increasing demand for healthy and organic foods, particularly for microgreens, which have strong flavour and aroma linked to their bioactive components. Microgreens are young vegetables that are harvested after the seeds have germinated but before the true leaves emerge....