Research works

DICTO ATOM-13×13: thirteen clusters of thirteen, twelve around one, six golden and seven periodic, with the pieces that fill between them

Twelve equal spheres can touch a thirteenth and no more (Schütte and van der Waerden 1952), and twelve atoms round one make the icosahedral cluster of liquids and metals (Frank 1952). We set thirteen polyhedral thirteens side by side, each a centre and twelve around it. Six are g...

Denotational Semantics for Probabilistic and Concurrent Programs

We develop a denotational model for probabilistic and concurrent imperative programs , a class of programs with standard control flow via conditionals and while-loops, as well as probabilistic actions and parallel composition. Whereas the semantics of concurrent programs and of r...

Learning Optimal Classification Trees Robust to Distribution Shifts

We consider the problem of learning classification trees that are robust to distribution shifts between training and testing/deployment data. This problem arises frequently in high stakes settings such as public health and social work where data is often collected using self-repo...

Where You Live and Where You Are Treated: Addressing Disparities in Esophageal Adenocarcinoma

Abstract Background Lower socioeconomic status conveys a known survival disadvantage for patients with esophageal adenocarcinoma (EAC). The potential role of the treating center volume in mitigating this disparity has not been described to date. Methods Non-metastatic EAC patient...

What Do These Words Actually Mean? A Reader's Guide to the Vocabulary of Jesus' Teachings

Plain-English definitions of kingdom, faith, metanoia and parable, as background reading on Jesus' teachings alongside The Billionaire Christ Mind. Few bodies of teaching have been quoted as often, or explained as differently, as the sayings attributed to Jesus. Some readers arri...

Citizens’ assemblies propose ambitious climate policy but impacts remain limited

Abstract Climate citizens’ assemblies convene randomly selected citizens who, after structured learning and deliberation, develop policy recommendations. Yet, whether they produce more ambitious recommendations and influence political decisions remains contested. Here we conduct...

Edited HSPCs rescue frataxin deficiency and inflammation-driven multisystemic pathology in Friedreich’s ataxia mice

Friedreich’s ataxia (FRDA) is a multisystemic neurodegenerative disorder caused by GAA repeat expansion in intron 1 of frataxin ( FXN ), resulting in FXN deficiency and mitochondrial dysfunction. Current therapies do not correct the underlying genetic defect. Here, we demonstrate...

A 3D Finite-Element Workflow for Mapping Earthquake Nucleation Tendency Under Tectonic Loading in Embedded Frictional Fault Systems

Abstract Dynamic-rupture simulations commonly prescribe rupture initiation, which complicates assessment of where instability would preferentially localize for a given fault geometry and tectonic loading. We present a 3D finite-element workflow that maps relative nucleation tende...

Highlights from an early base camp in Beringia 13,800 years ago: Shég’ Xdaltth’í’ and the Late Pleistocene peopling of Alaska

Human dispersal across the Bering Land Bridge (BLB) was a key event in the peopling of the Americas, but Beringia’s archaeological record remains poorly understood. In response, the Shég’ Xdaltth’í’ site in interior Alaska has been the focus of a multi-disciplinary study since 20...

Interferon-λ inhibits immunopathology and boosts T cell–mediated immunity in a mouse model of mucosal viral infection

Interferon lambda (IFN-λ) has emerged as a critical inducer of immune regulation in addition to its mucosal antiviral properties. However, the cellular and molecular mechanisms that govern its dual role during viral infections remain unclear. Here, we discovered that mucosal deli...

Seabirds and native vegetation drive ecosystem processes that support atoll island resilience

Ecosystem restoration is expected to enhance ecosystem resilience to climate change, but few empirical and mechanistic demonstrations of such assertions exist. Here, we explore this topic for tropical atoll systems, combining science on nutrient subsidies and geo-ecological funct...

Concise ethnobotanical review and botanical pharmacognosy of turmeric rhizome ( Curcuma longa L.)

Context Turmeric (Curcuma longa L. Zingiberaceae) is a highly valued botanical medicine worldwide and has emerged as among the best-selling herbal products in North America.Objective Presented an ethnobotanical record of turmeric use to present a context for this edition on turme...

Public Perceptions of Timeliness for AI Use and Human Oversight

This cross-sectional study assesses perceptions on use of artificial intelligence (AI) for medical patient portal messaging and mental health support, with opinions stratified by birth generation.

The Seeker's Word List: Nine Self-Culture Terms, Defined in Plain English

Nine words that show up in self-culture writing, from discipline to liberation, defined plainly as background reading for The Billionaire Self-Culture. Personal-growth writing has its own dialect. Open nearly any book on the subject and you will meet words such as discipline, abu...

Intermittent or Continuous Renal-Replacement Therapy in Acute Kidney Injury

BackgroundThe preferred method of renal-replacement therapy for acute kidney injury in critically ill patients remains uncertain. MethodsIn this multicenter, open-label, noninferiority trial, we randomly assigned critically ill adults with acute kidney injury who had indications...

Evaluation of Rare MCOLN1 Variants in a Large Cohort of α‐Synucleinopathies

Note: Genomic position was based on GRCh37.Variants were classified according to the 2015 American College of Medical Genetics and Genomics (ACMG) and Association for Molecular Pathology (AMP) joint consensus guidelines, with P indicating that the variant is pathogenic.Function p...

Cultural Engagement and Hospital-Treated Mental Disorders in Older Adults

Importance Cultural engagement is associated longitudinally with better mental health and reduced depression incidence, but evidence has largely relied on self-reported symptoms and diagnoses, leaving uncertainty about clinically recorded disorders, and residual confounding remai...

A spatial map of the atmospheric limb of a hot Jupiter

Abstract Planets are inherently three-dimensional objects shaped by their thermal structure and dynamics. Observations of transiting exoplanets have begun to uncover this three-dimensional nature, with JWST measuring their dayside atmosphere structure with eclipse mapping and exp...

Assessing pan-European soil resilience by combining modelled soil erosion with LUCAS topsoil indicators

Background Soil erosion and topsoil chemical condition are usually assessed separately, although both shape how soils respond to land use pressure. This study tested whether the two are related across Europe and how robust composite indicators of topsoil condition are between sur...

A taxonomy of reliability indices for cluster‐level constructs measured by multiple individual‐level indicators

Abstract Generalizability theory (GT) provides a variety of intraclass correlation coefficients (ICCs) to quantify reliability across different conditions of measurement—for example, scale and interrater reliability quantify generalization across items and raters, respectively. I...