Research works

Clinical relevance of serum full-length glypican-3 in unresectable hepatocellular carcinoma treated with atezolizumab and bevacizumab

Abstract Biomarkers that can predict patient survival and the therapeutic response to atezolizumab and bevacizumab (Atezo/Bev) as first-line chemotherapy for unresectable hepatocellular carcinoma (HCC) have yet to be identified. We aimed to determine whether the serum full-length...

Urologic complication rates after kidney transplantation using donor kidneys with duplicated or multiple ureters: a systematic review and meta-analysis of case series

Abstract Background The scarcity of donor kidneys often turns anatomically variant grafts into an allocation problem, with duplicated ureters frequently declined because of concerns about ischemic vulnerability and subsequent urological complications. This systematic review and m...

From Signals to Measurands: A Measurement-Science Roadmap for Reproducible Analytical Biochemistry

Abstract Analytical biochemistry often reports kinetic or binding constants as though they were observed directly. Each result is instead inferred from an instrumental signal. Calibration establishes the scale, biochemical and observation models connect the signal to a target, an...

Beyond T3: The Emerging Role of 3,5-Diiodothyronine in Mitochondrial Thyroid Hormone Signaling

Thyroid hormone physiology has traditionally been understood through the hypothalamic–pituitary–thyroid (HPT) axis and the genomic actions of triiodothyronine (T3). However, advances in thyroid hormone biology have expanded this classical paradigm, demonstrating that thyroid horm...

Integrated analysis of single-cell and transcriptome data reveals temporal dynamics of microglial phagocytic reprogramming in neuropathic pain progression

Abstract Neuropathic pain (NP) often progresses from acute to chronic, but the mechanisms driving this transition remain unclear. Microglia play a central role in spinal sensitization, yet their functional evolution during pain chronification is poorly understood. Through integra...

Thermodynamic analysis of COx hydrogenation to light olefins using carbon-neutral feedstock mixtures

The hydrogenation of carbon oxides to light olefins offers a promising route for the production of platform chemicals from carbon-neutral feedstocks. However, the thermodynamics that determine product distribution remain insufficiently understood, particularly under realistic mul...

Stage-specific threats reveal the inadequacy of adult-centered conservation

In an era of severe global biodiversity threats, understanding the link between species’ traits and their endangerment helps uncover causes of risk and infer threats to understudied species. Most animals have complex life cycles with distinct stages that may face stage-specific t...

Modelling convective cell occurrence in proximity to cold fronts using extreme gradient boosting

Machine learning is emerging as a valuable tool for convection-related applications such as post-processing numerical weather prediction output, improving understanding of convective storm climatology and potentially improving existing convective parameterization schemes. In a ra...

In-plane vector-field imaging of propagating surface phonon polaritons

Polariton interferometry through optical near-field microscopy has become a powerful tool in nanophotonics, enabling direct spatial access to the propagation characteristics of strongly confined, evanescent polariton modes. Scattering-type near-field optical microscopy has mature...

The transcriptome construction and microbial succession pattern in the intestinal tract of 3–5 month-old yak calves

Abstract This study investigated age-dependent intestinal development in yak calves by integrating intestinal morphology, 16S rRNA sequencing, and jejunal transcriptome analyses across 3, 4, and 5 months of age. Results demonstrated progressive intestinal maturation characterized...

Family resilience and its influencing factors among families of children with malignant tumors during initial chemotherapy: a cross-sectional study

Abstract Background During the primary chemotherapy of pediatric malignant tumors, the physical and mental health of family members can be seriously affected. Family resilience has been shown to be a protective factor. Objectives To investigate family resilience in families with...

SOLiD‐MaP: A Photoproximity Labeling Platform for Small Molecule Binding Site Mapping on RNA

RNA-targeting small molecules are emerging as promising therapeutic modalities, but their development requires methods that define binding sites and evaluate RNA target selectivity. Existing approaches for detecting ligand-RNA interactions have provided powerful foundations, yet...

A Simulated IoT Embedded System for Classroom Indoor Air Quality, Noise, and Lighting Monitoring: Architecture and Firmware Performance Analysis

Environmental conditions such as inadequate lighting, excessive noise, and poor indoor air quality can negatively affect students’ health, comfort, and academic performance. Although recent Internet of Things (IoT) technologies have enabled low-cost environmental monitoring syste...

Health beliefs, medication adherence, and blood-pressure control in rural Bangladeshi hypertension: an exploratory sequential mixed-methods study

Abstract Background Hypertension control remains poor in low and middle income countries, including Bangladesh, where medication adherence is often suboptimal. How patients' health beliefs translate into adherence and blood pressure control in rural settings is poorly understood....

Machine-optimized parametric computer assisted design (CAD) of a stable flying wing UAV glider

Abstract Designing a statically stable flying-wing UAV glider is a highly nonlinear problem in which small geometric changes cause large shifts in stability and performance. While prior work has applied gradient-based and gradient-free methods to flying-wing aerodynamic optimizat...

Gut microbial phenol impairs energy metabolism and promotes sarcopenic obesity-like phenotypes in mice

Abstract Gut microbial phenol has been recognized as a uremic toxin associated with chronic kidney disease; however, its effects under preclinical conditions remain unclear. In this study, we established a mouse model with increased endogenous phenol production using a tyrosine-r...

Instrumental activities of daily living in older adults with epilepsy: A cross‐sectional and longitudinal multicenter study

OBJECTIVE: Instrumental activities of daily living (IADLs) represent a critical but understudied measure of day-to-day function in people with epilepsy (PWE). In the multicenter Brain Aging and Cognition in Epilepsy (BrACE) study of PWE ≥55 years of age, we examined the proportio...

Adolescents’ exposure to unhealthy foods and beverages in and around schools in urban Comoros: a cross-sectional mixed-methods study

Abstract Background In Comoros, undernutrition among adolescents persists while overweight and obesity are increasing, particularly in urban settings. Although schools are recognized as key platforms for promoting healthy eating behaviors, school food environment (SFE) remain poo...

Nonexistence of consecutive powerful triplets around cubes with mixed prime factorizations

A positive integer is powerful if every prime in its factorization occurs with exponent at least two. The Erdős–Mollin–Walsh conjecture asserts that no three consecutive integers are all powerful. Chan (Integers 25 (2025), #A7) excluded triples of the form x³−1=p³y², x³, x³+1=q³z...

Predictive value of perioperative hypothermia for postoperative muscular calf vein thrombosis after total knee arthroplasty: a retrospective cohort study

Abstract Objective To investigate the association between perioperative hypothermia and postoperative muscular calf vein thrombosis (MCVT) in patients undergoing total knee arthroplasty (TKA), and to evaluate the predictive performance of perioperative core temperature indicators...