Research works

SYNERGISTIC DEGRADATION OF POLYETHYLENE BY INDIGENOUS FUNGAL ISOLATES AND THEIR CONSORTIUM

Polyethylene is a widely used synthetic polymer whose extensive consumption has led to serious environmental concerns. Conventional disposal methods such as source reduction, incineration, and landfilling have inherent limitations, highlighting the need for sustainable alternativ...

Adipose Tissue Browning in MASLD and Its Molecular Mechanisms and Metabolic Crosstalk

PURPOSE OF REVIEW: Metabolic dysfunction-associated steatotic liver disease (MASLD) is an increasingly prevalent complication of obesity and metabolic dysregulation, with limited therapies targeting upstream drivers of disease. Adipose tissue has emerged as a central regulator of...

AI, Digital Tools Can Operationalize Readiness for Crisis and Emergency Management

_ This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper SPE 229328, “Operationalizing AI for Crisis and Emergency Management,” by Ashish Chandrashekhar Kulkarni and Ashwina Das Kulkarni, The Bell Group. The paper has not been peer-reviewed....

AN EFFECTIVE MANAGEMENT OF ANANTAVATA WITH SPECIAL REFERENCE TO TRIGEMINAL NEURALGIA: A CASE STUDY

Trigeminal neuralgia (TN) is a neuropathic disorder marked by sudden, intense, stabbing pain in the lower face and jaw, typically affecting one side of the face and often triggered by simple activities like touching the face, brushing teeth, or exposure to cold wind.[1] The pain...

ASSESSMENT OF THE ANTI-INFLAMMATORY ACTIVITY OF SIDDHARTHAKADI AGAD BY AN IN VITRO METHOD

Inflammation is a protective physiological response against harmful stimuli such as infection, injury, and toxins; however, chronic inflammation may lead to tissue damage and various pathological conditions. Siddharthakadi Agad, a classical polyherbal formulation described in Cha...

Non-medical surgical delay increases one-year mortality following hip fracture

Aims: This study aimed to assess the association between surgical delay due to non-medical reasons and one-year mortality in patients with hip fracture, and to explore whether a dose-response relationship exists between increasing time to surgery and mortality risk. Methods: A re...

Impact of the Triple D Method on Conflict Management and Workplace Engagement

BACKGROUND: Although nurses' attitudes toward teamwork and work-related well-being have been explored, evidence is limited on the impact of a team-based method to manage interpersonal conflicts among nursing staff members. LOCAL PROBLEM: Nursing leaders on a 20-bed critical care...

President’s Column: Energizing Tomorrow: Let’s Keep Doing It!

As I write this column, the last of my year as SPE President, I have naturally been reflecting on what I want to leave you with in this final communication. I’m not quite at the end of my journey; in fact, I still have 3 months left until I hand the gavel over to the most capable...

Periprosthetic joint infection

Infection is one of the most devastating complications following arthroplasty. The National Institute for Health and Care Research (NIHR) funded the multinational INFection ORthopaedic Management (INFORM) research programme to study this problem comprehensively, and then funded I...

Something Doesn’t Look Right: Recognizing and Managing Limb-Length Discrepancy

Leg length discrepancy (LLD) is a frequently encountered yet often underrecognized musculoskeletal condition in children. Minor differences in leg length are common and typically benign; however, more significant discrepancies may reflect underlying congenital, developmental, or...

STRUCTURE-BASED DRUG DESIGN FOR PARKINSON'S DISEASE: MOLECULAR DOCKING ANALYSIS OF NOVEL COMPOUNDS

Parkinson's disease is a progressive neurodegenerative condition characterized by dopaminergic neuron destruction and misfolded proteins. Current treatments focus on motor symptoms, but do not target neuronal degeneration. Recent studies suggest a connection between lipid metabol...

Phenotypic divergence in rotator cuff tear and volumetric muscle loss mouse models following fibroadipogenic progenitor depletion

Aims: Fibroadipogenic progenitors (FAPs) are a group of resident muscle stem cells capable of differentiating into fibroblasts and adipocytes, contributing to intramuscular fibrotic and fatty degeneration after injury. However, FAPs are also thought to play a crucial role in musc...

DEVELOPMENT AND VALIDATION OF UV SPECTROSCOPIC METHOD FOR SIMULTANEOUS ESTIMATION OF BEMPEDOIC ACID AND ATORVASTATIN CALCIUM IN PHARMACEUTICAL DOSAGE FORM

A fixed dose combination of Bempedoic acid & Atorvastatin calcium is used in ratio of 180 mg: 80 mg as tablet for treatment of Hypercholesterolemia. A simple, precise, accurate and economical UV spectrophotometric First order derivative spectroscopy and Absorbance ratio methods w...

From retail transactions to enterprise knowledge: brand-level association rules via FP-Growth algorithm

Purpose This study aims to examine brand-level co-occurrence structures in retail transaction data using the FP-Growth algorithm. It explores how validated association-rule outputs may support enterprise decision-making by serving as interpretable decision-support artefacts withi...

Air pollution and suicide mortality in the UK: implications for environmental and mental health policy

Abstract Air pollution is a well-established risk factor for physical illness and premature mortality, yet its relationship with suicide remains less well understood, particularly at the national level and over longer periods of exposure. Although previous studies have reported p...

Certified upper bounds for Fejes Tóth's point-goalie problem at n = 4 and 5

In 1974 László Fejes Tóth posed the following problem: place n points in the plane so asto minimise the largest distance from a line meeting the unit-radius disc to the nearestpoint. Writing r_n for the optimum, he proved r_1 = r_2 = 1 and r_3 = 3/5 exactly, gaveconstructions sho...

Bioelectrical impedance-derived total body water for predicting exertional rhabdomyolysis-induced acute kidney injury during military training: a prospective cohort study

Abstract Background Exertional rhabdomyolysis-induced acute kidney injury (AKI) is a serious complication among military recruits undergoing intensive physical training in hot climates. Current screening parameters, including body mass index and urine specific gravity, have limit...

Multiphase Pump Solution Deployed in World’s Deepest Subsea Heavy Oil Field

_ This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper OTC 36841, “Atlanta: Boosting the World’s Deepest Subsea Heavy Oil Field,” by Marcelo Paulino and Henrique S. Cerqueira, SPE, Brava Energia, and Christophe Vielliard, SPE, SLB OneSubsea...

Finite Support and Preparation Criteria for Independent Effective Subsystems: A Contract for Non-Injective Admissibility

A recurring assumption in emergent-physics programmes is that once a fundamental description is given, the decomposition of the world into independently preparable subsystems comes for free. We show that on a substrate not supplied with a subsystem factorisation this assumption s...

SAMPRAPTI BHANGA OF STHANIKA CHIKITSA IN AYURVEDA ON KANDU IN KITIBHA KUSHTA (PSORIASIS): A COMPREHENSIVE REVIEW

Kandu in Kitibha Kushta are among the most clinically significant skin disorders described in Ayurveda, and their close correlation with pruritic psoriatic lesions makes them highly relevant in present-day dermatology. Kitibha Kushta is classically described by Shyava varna, Khar...