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TRAIL splice variant TRAILshort disrupts T cell receptor signaling and promotes immune tolerance in vivo

TRAIL is a TNF family ligand that trimerizes TRAIL-R1 (DR4) or TRAIL-R2 (DR5) to induce apoptosis, necroptosis, and/or NF-κB activation in receptor-bearing cells. We previously identified TRAILshort as a splice variant of TRAIL that lacks cysteine 230, cannot trimerize, and acts...

How to Break LambdaCDM

One-page challenge to ΛCDM. Starting from the COW experiment (gravity couples to quantum phase), a single disorder weight derived via Tsallis non-extensive mechanics is inserted into the Einstein equation. The resulting source term, scaled by the rigid constant α0=2.618, accounts...

Water Availability Modulates Leaf Functional Trait Responses of Robinia pseudoacacia L. Seedlings to Nitrogen–Phosphorus Supply

Water availability strongly influences nutrient utilization and plant adaptive strategies, yet how nitrogen (N) and phosphorus (P) supply interact with water conditions to regulate leaf functional traits remains insufficiently understood. In this study, Robinia pseudoacacia L. se...

Spectral Detection of Correlated Errors on Superconducting Quantum Hardware via Parity-Circuit Canaries

Standard device characterization protocols, such as Randomized Benchmarking (RB), typically report averaged, independent error rates per qubit. However, these methods are largely blind to correlated errors between neighbouring qubits: errors that fundamentally break the independe...

Private Languages

Strategic communication often relies on anchors observed by the sender but not by the receiver. An analyst may report against a proprietary valuation model, an auditor against an internal score, a manager against an accounting estimate, or an institution against its own standard....

Selberg Trace Formula Links Hyperbolic Spectra, GUE, and Riemann Zeros — E8 Intelligence Research

FINDING: Selberg trace formula connects spectral statistics of Laplacians on hyperbolic surfaces to GUE random matrix theory, with Riemann zeta zeros as a quantum chaotic spectrum. | MATH: Selberg trace formula: ∑_j h(ρ_j) = (area/4π)∫_{-∞}^{∞} h(r) r tanh(πr) dr + ∑_{γ} ∑_{k=1}^...

Between Capability and Consequence: Governing AI-Mediated Institutional Action

Artificial-intelligence governance often treats capability, autonomy, permission, authority, and consequence as if they formed one scale. They do not. A system may perform a task without being permitted or institutionally assigned to perform it; an authorised contribution may nev...

Operationalizing Contingency: The Axiomatic Model (AXM) for Applied AI Alignment

Abstract Current methodologies for Artificial Intelligence alignment operate under a fundamental systems vulnerability: they attempt to derive ethical constraints from historically biased human datasets. This reliance on subjective probability-averaging floods computational model...

EuroMillions Breakthrough Mining — 1243 Sources, 7975 Leads Extracted — E8 Intelligence Research

Mined 1243 lottery+quantum breakthroughs. Extracted 7975 leads across 13 categories. 6128 high-value leads found. Categories: {"CORRIDOR": 636, "FORMULA": 496, "GEOMETRIC": 657, "FORWARD_ATTEMPT": 661, "QUANTUM": 872, "TIMING": 169, "CELESTIAL": 582, "GEMATRIA": 620, "CONSTANT":...

A Real time Face Emotion Detection System Based on YOLO11

Modern Human-Computer Interaction (HCI) trends demand a shift toward emotionally intelligent systems capable of recognizing user affect. Standard computer vision setups typically process environment tasks sequentially, remaining blind to human psychological and physiological vari...

Spatial Coherence C_{ij} as a Substrate-Agnostic Information-Theoretic Primitive Volume II: Cross-Domain Validation of Collapse Signatures

Volume I of this series defined spatial coherence C_{ij} as a candidate substrate-agnostic information-theoretic primitive for complex networked dynamical systems under stress. It supplied the formal definition, justified the hybrid L1/L2 normalization, established analytic bridg...

From Fold to Materials

Published open-access status correction for From Fold to Materials, version 1.4.1. This patch removes erroneous prepublication wording from the already-published paper and changes no scientific content.

EuroMillions Breakthrough Mining — 1203 Sources, 7543 Leads Extracted — E8 Intelligence Research

Mined 1203 lottery+quantum breakthroughs. Extracted 7543 leads across 13 categories. 5699 high-value leads found. Categories: {"CORRIDOR": 597, "FORMULA": 457, "GEOMETRIC": 657, "FORWARD_ATTEMPT": 621, "QUANTUM": 833, "TIMING": 168, "CELESTIAL": 542, "GEMATRIA": 581, "CONSTANT":...

Microscopic Foundations of the HRDCC Framework

The microscopic physical foundations of the Holographic Rotation-Driven Cyclic Cosmology (HRDCC) framework are investigated by examining the internal physical processes associated with the Holographic Transition Core (HTC). Whereas previous papers established the effective cosmol...

EuroMillions Breakthrough Mining — 1189 Sources, 7389 Leads Extracted — E8 Intelligence Research

Mined 1189 lottery+quantum breakthroughs. Extracted 7389 leads across 13 categories. 5545 high-value leads found. Categories: {"CORRIDOR": 583, "FORMULA": 443, "GEOMETRIC": 657, "FORWARD_ATTEMPT": 607, "QUANTUM": 819, "TIMING": 168, "CELESTIAL": 528, "GEMATRIA": 567, "CONSTANT":...

Top 10 Tips Palliative Care Clinicians Should Know About Preventing Burnout

Health care worker burnout is a potential job hazard. Palliative care clinicians (PCCs) are especially vulnerable due to the intense emotional and challenging demands of the work. Creating environments for PCCs to thrive is the responsibility of the organization, however, PCCs ha...

Spectral Gap Undecidability: Hamiltonian Parameters Encode Turing Machines, Proving Algorithmic Impossibility — E8 Intelligence Research

FINDING: Spectral gap undecidability links Hamiltonian parameters to Turing machine encoding, proving that determining the energy gap of a quantum system is algorithmically impossible. | MATH: The spectral gap λ₁ - λ₀ (difference between ground and first excited energy eigenvalue...

EXTRACTED METHOD: gods_clock_glyph_timing — E8 Intelligence Research

rule: assign each glyph a time based on spiral revolution (1 rev = 1 day/month/year); detect clusters at solstices, equinoxes, lunar phases source: rlab #60 Author: Andrew Stewart Caldin, Independent Researcher, UK. Part of the E8 Intelligence Research series. Platform: e8intelli...

QUANTUM TUNNELING TO APEX PREDATOR MIGRATION CASCADE: A Comprehensive Monograph on Micro-to-Macro Physical Coupling in Biological Systems

This manuscript establishes a complete, first-principles derivation of the causal pathway linking a single quantum tunneling event in photosynthetic reaction centers to the synchronized migration of apex predators via multi-scale biological transduction. Beginning with the photoe...

From Fugitive Cash to Non-Fugitive Provisioning: The Mundellian Trilemma, External Debt Feedback, and the Design Space of Post-Employment Redistribution

The Mundellian trilemma is widely assumed to make large-scale redistribution — such as universal basic income — infeasible in an open global economy, yet this assumption has never been stated formally or tested dynamically. This paper constructs a four-bloc computational model of...