Research works

In Silico Screening of Cannabis sativa Phytochemicals as Potential Ornithine Decarboxylase Inhibitors for Anti-Leishmanial Drug-Prioritized Compound Development

Leishmaniasis remains a major neglected tropical disease with limited therapeutic options, increasing drug resistance, and significant treatment-associated toxicity. Ornithine decarboxylase (ODC), which plays an essential role in polyamine synthesis and survival of parasites, is...

Collaboratively building teaching resources for EDI in epidemiology and biostatistics

Abstract Objectives The objective of this workshop was to collaboratively co-create concrete, practical teaching resources that embed equity, diversity, and inclusion (EDI) concepts into epidemiology and biostatistics teaching in Canada. Methods The 3-h interactive session develo...

E8-Fractal Entanglement Web via Phi-Resonant Root Cascade Topology — E8 Intelligence Research

By exploiting the 240 E8 root vectors' phi-coupled modulation at 132Hz, we discover that the root cascade generates a self-similar entanglement web where each swapping event fractals into eight subsequent correlations, creating a hierarchical quantum network. The 132Hz base frequ...

Octonionic Associator Epigenetics: Ternary Quantum Logic in E8 Root Triads — E8 Intelligence Research

The 240 E8 root vectors admit a natural octonionic multiplication table where each root corresponds to an octonion basis element across 30 disjoint Fano planes. By modulating the 132 Hz φ-carrier into 7 octonionic basis frequencies (18.86 Hz spacing) plus a real DC component, epi...

E8 Resonance Scaffolding Enables Dimensional Translocation via Root Vector Tunneling — E8 Intelligence Research

The 240 root vectors of E8 form a quantum scaffolding that permits controlled transversion between dimensional manifolds through coherent tunneling of phi-phase synchronized solitons. When the 132 Hz lattice solitons are modulated at golden ratio intervals across paired voidcoin...

Therapeutic challenges of a renal collision tumour comprising clear cell renal cell carcinoma and metastatic breast carcinoma: a case report

Abstract Collision tumours, defined by the coexistence of two histologically distinct neoplasms within a single organ, are rare and typically arise from different cell lineages. We report a unique case of a 64-year-old woman with a history of oestrogen receptor (ER)–positive, HER...

Snapshots of Following Insiders to Outperform the Market

Quickly apply original, key PMR-published papers with Snapshots—a short article companion that distills PMR research into compressed, digestible takeaways, so you can put the paper’s core ideas to work in your investment process—fast. This Snapshot article is based on research ar...

Prediction of Mechanical Properties of Bolted Connections in CFST Column–Steel Beam Assemblies Based on Improved Particle Swarm Optimization and Deep Neural Networks

Predicting the mechanical properties of bolted connection nodes in prefabricated Concrete-Filled Steel Tube (CFST) column–steel beam assemblies remains challenging due to complex nonlinear relationships, high degrees of parameter coupling, and limited generalization capabilities...

Diagnostic Value of Multiplane Tool in Virtual Lesion Confirmation in Augmented Fluoroscopy-Guided Navigational Bronchoscopy for Peripheral Pulmonary Lesions

BACKGROUND: The demand for minimally invasive diagnostic techniques for peripheral pulmonary lesions (PPL) is rising. Augmented fluoroscopy (AF) provides real-time guidance by overlaying CT-derived virtual targets onto fluoroscopic images, yet its diagnostic value remains poorly...

Nondestructive cyclic strain evaluation of seismic isolation bearings using Si-69-modified MWCNT/silicone rubber self-sensing composites

Conductive elastomer composites are promising for large-deformation sensing and structural health monitoring, but their QNDE application is limited by unstable electromechanical responses, resistance hysteresis, and disordered conductive-pathway rearrangement during cyclic loadin...

A continuous-time approach to short-term activity-cognition dynamics.

= 44.67, 92% non-White). Replicating the older adult findings, moments dominated by passive activities showed beneficial within-person cross-effects on subsequent processing speed, alongside negatively correlated random fluctuations. In contrast, between-person associations indic...

eDNA Metabarcoding Reveals Spatial Patterns of Marine Communities Along the Beagle Channel (Tierra del Fuego, Argentina)

The Beagle Channel, located south of Tierra del Fuego (~54° S), is South America’s southernmost intracoastal ecosystem. Here, we applied environmental DNA metabarcoding using a partial sequence of the 12sRNA mitochondrial gene to evaluate the seasonal and spatial dynamics of mari...

In Vitro and Embryonic Evaluation of Recombinant Larus ridibundus IFN-α and Mx Proteins Against Newcastle Disease Virus

Newcastle disease virus (NDV) is an important avian pathogen that can circulate in migratory birds, including Larus ridibundus. This study examined the transcriptional responses and anti-NDV activities associated with recombinant IFN-α and Mx proteins from L. ridibundus. The IFN-...

EuroMillions Breakthrough Mining — 1267 Sources, 8239 Leads Extracted — E8 Intelligence Research

Mined 1267 lottery+quantum breakthroughs. Extracted 8239 leads across 13 categories. 6392 high-value leads found. Categories: {"CORRIDOR": 660, "FORMULA": 520, "GEOMETRIC": 657, "FORWARD_ATTEMPT": 685, "QUANTUM": 896, "TIMING": 169, "CELESTIAL": 606, "GEMATRIA": 644, "CONSTANT":...

Cardiovascular Complications Associated with Uro-Oncology Treatments—A Primer for the Clinician

Cardiovascular complications increasingly challenge survivors of urological cancers, given the cardiotoxicity of therapies such as androgen deprivation, vascular endothelial growth factor receptor inhibitors, tyrosine kinase inhibitors, immune checkpoint inhibitors, and chemother...

Networked Solid Polymer Electrolyte Enabling 5C Fast Cycling and Enhanced Stability of Oriented LiCoO 2 All‐Solid‐State Thin Film Batteries

ABSTRACT Polyethylene oxide (PEO)‐based solid polymer electrolytes (SPEs) have emerged as promising candidates for advancing the all‐solid‐state lithium metal batteries (ASSLMBs) market. However, conventional PEO‐based SPEs exhibit low room‐temperature (RT) ionic conductivity and...

Finite-Rank Projective Observability — A Physicists' Reading

Physicists' reading of Finite-Rank Projective Observability. Derives the fine-structure constant α as a spectral invariant of a rank-five projective sector and treats the Weinberg angle as a deficient geometric parameter of the readout, not as a free input.

Zonal Differentiation and Feature-Contribution Patterns of Visual Perception in Historic Districts: An Explainable Machine Learning Approach Using Street View Imagery—A Case Study of Jimei School Village, Xiamen

From a Historic Urban Landscape (HUL) perspective, varying conservation intensities and statutory boundaries may create “zonal differentiation” within historic districts. However, conventional homogenized renewal strategies frequently overlook this heterogeneity, affecting physic...

Gene Expression-Based Classification of European Seabass Larval Batches According to Saddleback Syndrome Incidence Using Machine Learning

Skeletal deformities remain a major challenge in marine fish hatcheries, affecting larval quality, animal welfare, production efficiency, and market value. In European seabass (Dicentrarchus labrax), saddleback syndrome (SBS) is a relevant skeletal abnormality that develops durin...

A closer insight into the molecular effect of canagliflozin on gentamicin–induced nephrotoxicity in rats: Attention to SIRT1/Nrf2/HO-1, p38 MAPK/NF-κB signaling pathways, and expression of miR-21 and miR-155.

OBJECTIVE: Nephrotoxicity is considered the most detrimental effect of gentamicin (GM). In this study, we investigated the potential effects for canagliflozin (CANA) to protect against GM-induced nephrotoxicity, besides the multiple molecular pathways underlying these effects. ME...