Research works

Starch as a Polymer-Based Medium Modifier to Analyze Enzyme Activity under Conditions Close to Intracellular Media: Butyrylcholinesterase as a Model Enzyme

Abstract The study demonstrates the possibility of using starch to model macromolecular crowding and intracellular medium. A kinetic approach is used to reveal specific functioning of butyrylcholinesterases from different sources in the starch medium. In the study solutions, the...

Against Treason: An Argument from Political Obligation

Abstract There has been increasing scepticism about the meaning, relevance, and normative import of treason legislation. Relatedly, there is scepticism about whether treason constitutes a distinct moral wrong. These worries are often grounded in either the idea that the distincti...

Targeting Hippocampal PTEN Suppresses Ferroptosis and Rescues Cognitive Decline in Alzheimer's Disease via Dual AKT/GSK3β/Nrf2 and AKT/STAT3 Axes

Elevated phosphatase and tensin homolog (PTEN) expression is observed in Alzheimer's disease (AD) brain, yet the precise mechanism through which PTEN contributes to AD progression remains undefined. This study provides the direct evidence that PTEN promotes neurodegeneration by d...

Transcriptomic and Metabolomic Analysis Following LmRab11A Knockdown Reveals Its Role in Metabolic Regulation and Molting in Locusta migratoria

Rab proteins are key members of the Ras superfamily that regulate vesicular trafficking in eukaryotic cells, ensuring accurate cargo transport and cellular homeostasis. To investigate the functional role of Rab proteins, RNA interference (RNAi) was employed to silence LmRab11A in...

Very‐Long‐Period Seismic Signals During Lateral Dike Propagation at Piton de La Fournaise Volcano

Abstract We report a previously undocumented sequence of very long period (VLP) signals preceding the September 2022 eruption at Piton de la Fournaise. These events occurred during lateral magma propagation and exhibit quasi‐periodic sawtooth‐shaped displacement transients. Seism...

Microglia replacement therapy for neurological diseases: a mechanistic perspective focused on the Golgi apparatus

Microglia-mediated neuroinflammation is a pathological hallmark of various neurological diseases. Altered microglial states promote disease progression and induce an inflammatory microenvironment. Therapies aimed at modulating microglial signaling demonstrate certain therapeutic...

Enhancing salt stress tolerance in sugar beet via TiO 2 nanoparticles: a machine learning approach

In this study, the biostimulant potential of titanium dioxide (TiO2) nanoparticles was investigated to enhance sugar beet (Beta vulgaris L.) seed response to salt stress. Controlled applications were conducted at different NaCl (0–200 mM) and TiO2 (0–1,800 ppm) levels, and eight...

Efficient sampling from circular distributions: extensions to toroidal and spherical distributions

In this article, we present a unified and computationally efficient framework for modeling and sampling directional data across a wide range of directional distributions. The core contribution is a modified acceptance–rejection algorithm that constructs a piecewise constant envel...

The Oxygenation–Nutritional–Inflammatory (ONI) index and the risk of osteoradionecrosis of the jaw in locally advanced nasopharyngeal carcinoma: a continuous multidimensional modeling analysis

Osteoradionecrosis of the jaw (ORNJ) remains a major late complication in patients with locally advanced nasopharyngeal carcinoma (LA-NPC) treated with definitive concurrent chemoradiotherapy (CCRT), for which current risk models based on dosimetric and dental factors do not full...

Laser powder bed fusion of modified high entropy alloys

Abstract This review compiles and analyzes the current state of the art of modified high entropy alloys (MHEAs) processed by laser powder bed fusion (LPBF), establishing composition-processing-microstructure-property relationships that define their printability, structural integr...

Assessing Linguistic and Content Characteristics of First-Grade Students’ Texts Using Generative AI

The present study examines how accurately a common large language model (ChatGPT 5.0) assesses linguistic and content characteristics of texts written by first-grade students. The focus is on the consistency of LLM assessments and their alignment with human assessments. The datab...

Socioeconomic conditions and children’s out-of-home care in high-income countries: a systematic review and meta-analysis

Background Socioeconomic inequalities in children’s out-of-home care (OHC) are a major public health problem. Though widely documented, no review has systematically synthesised evidence across high-income countries. We aimed to compare the risk of OHC for children experiencing di...

On Numbers of the Form 5^k 2^m - 1 Generated from Mersenne Numbers

We present a numerical experiment in which the neighbour-sum transform T, defined as (T a)_n = a_{n-1} + a_{n+1}, is applied to Mersenne numbers M_n = 2^n - 1, followed by repeated division by powers of 2. After several iterations, a new class of numbers emerges: those of the for...

Definability of quantization inputs: a Padoa-style classification and its boundary

Quantum theory carries several discrete or numerical inputs that are routinely described as "not derived" from an underlying substrate. This paper asks a sharper question: for which of these inputs can "not derived" be upgraded to a proof of undefinability, and for which is this...

PFUSRC-132C A Panoramic View of the PFUSRC System — Extending Living Calculus Conclusions to the Complete Seven-Layer Cosmic Ontology

Building upon the topological core deductions of PFUSRC-132B Living Calculus, this formula-free panoramic overview elaborates the full PFUSRC 11-dimensional triple coaxial 45° biconical unification system for readers without specialized mathematics or physics backgrounds. PFUSRC-...

The Human and AI: Toward a Theory of Third Nature

Author’s publication name: Max Scenner (Alexander Neretin). This philosophical and methodological study examines artificial intelligence not merely as a technological instrument, but as a sign and mechanism of a deeper historical transition: the emergence of Third Nature. Third N...

Ultralow Noise Orthogonal Fluxgates Enabling Weak Magnetic Field and Biomolecular Detection

Abstract Noninvasive detection of ultra-weak biomagnetic signals is crucial for modern biosensing, but conventional magnetic sensors are fundamentally limited by intrinsic noise. Orthogonal fluxgates (OFGs) enable high signal-to-noise-ratio detection of weak magnetic fields, yet...

Boundary-Heat Pair Reconstruction for Ramanujan's Third-Order Mock-Theta Completion: Sesquilinear Spectral Packets and a Mellin Regulator Obstruction

This paper develops a boundary-heat and spectral reconstruction theory for a positive quadratic observable derived from the positive-frequency Fourier coefficients of Zwegers’ vector-valued completion of Ramanujan’s third-order mock theta functions. For a damping parameter $\sigm...

A Consulting Method for Operational Process Diagnosis and AI Readiness

This document describes the consulting method used to diagnose, assess, and improve operational processes in organizations, together with the standards and methodologies it draws on. The method is organized into three progressive levels — Initial Diagnosis, Maturity Diagnosis, an...

Retrospective analysis of postoperative complications and risk factors in middle ear surgery

Background Postoperative complications following middle ear surgery present ongoing challenges despite advances in surgical techniques. A comprehensive analysis of complication patterns, associated risk factors, and their interactions with patient comorbidities is needed to impro...