Research works

Circulating Hepatocyte Nuclear Factor-4α is Associated with Metabolic Dysfunction and Hepatic Remodeling in Fructose-Induced Metabolic Syndrome: An Immunomorphometric Study

Metabolic syndrome (MS) driven by excessive dietary fructose is associated with progressive hepatic injury including steatosis, inflammation, fibrosis, and apoptosis. Hepatocyte nuclear factor-4α (HNF4α), a master transcriptional regulator of hepatic metabolism, is typically down...

Translating Hair Longevity Biology into Cosmetic Science: A Narrative Review and Three-Pillar Domain-Based Framework

Hair aging results from the parallel, interconnected decline of three biological compartments — the scalp, the hair follicle, and the hair fiber — driven by intrinsic aging processes and cumulative environmental exposure. Existing conceptual models, including the Hair Aging Hallm...

The consequences of mitochondrial dysfunction and upregulated glycolysis on innate and adaptive immune responses

Mitochondrial dysfunction occurs in response to a variety of causes. It leads to partial or complete inhibition of oxidative phosphorylation and, consequently, to the upregulation of fermentative glycolysis which remains the main or only energy-producing pathway. Mitochondrial dy...

Stakeholders meet in Washington to sign SAMHSA's “Pledge”

On July 29, the Substance Abuse and Mental Health Services Administration (SAMHSA) held a meeting asking substance use disorder and mental health treatment providers to sign a pledge. The signing included the person's name, organization and email address, and the pledge is availa...

Application of Resident Disease Screening Paradigm on Early Warning of Instability of Anaerobic Digestion of Food Waste

Early warning has been widely proven to be reliable in lowering the risk of instability for biological processes. However, it is very difficult for the warning systems used currently to achieve satisfactory accuracy, timeliness and universality simultaneously. This study develope...

Fluxus and Artists' Publications: The Case of Grapefruit

Fluxus artists sought to transform artistic production into a form that was more accessible, reproducible, and closely connected to everyday life by challenging art’s dependence on institutional spaces, market relations, and traditional aesthetic hierarchies. Within this framewor...

Augmentation-Ideal Realization of Special Nottingham Congruence Series and Cartier Indecomposables

Let k = F_p with p >= 5, let A = k[[x_1,...,x_n]] with n >= 3, and let m be its maximal ideal. Let G be the group of volume-preserving formal automorphisms of A tangent to the identity, let G_s consist of those g in G such that g(x_i) - x_i lies in m^s for every i, and let T_N =...

AmTH Plays an Indispensable Role in Larval Development as Well as Adult Immunity in Apis mellifera

In insects, tyrosine hydroxylase (TH) plays crucial roles in a wide variety of biological processes. However, its function in Apis mellifera remains unknown. Here, AmTH (A. mellifera TH) was cloned and characterized. Expression profiles at different stages showed that AmTH was hi...

Artificial intelligence-assisted design and optimization of radiation shielding materials for medical applications

The increasing use of ionizing radiation in diagnostic imaging, radiotherapy, nuclear medicine, and interventional procedures has intensified the need for lightweight, effective, and clinically reliable shielding materials. This systematic and critical review evaluates the role o...

A Global Quasi-Symplectic Projection Method for the Spatial N-Body Problem: Explicit Preservation of Poincaré–Noether Invariants with O(N) Complexity

Long-term numerical integration of the spatial N-body problem suffers from systematic unphysical drift of the fundamental integrals of motion: total energy Etot, linear momentum Ptot and angular momentum Ltot. Standard high-order explicit integrators (e.g., classical 4th-order Ru...

Ends of the Tunnel: An Original Strategic Board Game Concept Combining Collective Movement, Anticipation, and Educational Learning

Ends of the Tunnel is an original strategic and educational board game concept created by Doumbia Amara from Côte d'Ivoire (Ivory Coast), Africa. This project presents a unique gameplay experience based on the collective movement of a gigantic anaconda trapped inside a volcanic m...

Stability Study of Meropenem 50 mg/mL Eye Drops in Polypropylene Dropper Bottles

Background/Objectives: Meropenem is a broad-spectrum carbapenem antibiotic with demonstrated efficacy against multidrug-resistant Gram-negative pathogens. Although its use as an ophthalmic formulation is off-label, growing clinical evidence supports its application in severe ocul...

Effectiveness of a Brief Internet-Based Workplace Training Program to Support Help Seeking for Mental Ill-Health: Cluster Randomized Controlled Trial

Abstract Background Depression and anxiety are prevalent in working-aged adults. Although treatment provided by health professionals can improve symptoms and functioning, many people experiencing mental ill-health do not seek help. There have been very few effective interventions...

Residual-Rank Entanglement of Conjugate Weil Pairs in the Spectral Admissibility Cascade

We compute the entanglement entropy of a closed conjugate Weil pair $\{c,q-c\}$ along the spectral admissibility cascade of the Cosmochrony programme, where entanglement is the infra-projectable invariant of a non-decomposable joint fibre of the non-injective projection. The bipa...

Plant-Derived Compounds as Antibiotic Adjuvants Against Drug-Resistant ESKAPE Pathogens: Mechanisms of Action, Synergistic Strategies, and Translational Challenges

Background/Objectives: Antimicrobial resistance among ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) pathogens has become a major global health threat, significantly reducing t...

Global Regularity via Spherical Compactification for the 3D Navier–Stokes System

The global regularity problem of the three-dimensional incompressibleNavier–Stokes equations is one of the most famous unsolved mathematicalproblems listed on the Clay Mathematics Institute Millennium Prize list.Over the past decades, a large number of scholars have carried out e...

Microbial Dyes for Textiles: Advances, Challenges, and Sustainable Paths - A Review

The application of synthetic dyes by the global textile industry, which are well known to be non-environmentally friendly andnon-biodegradable, has triggered the search for effective sustainable alternatives. Microbial dyes isolated from themicrobes such as bacteria, fungi, yeast...

Oral Edible Zein/CitricAcid Nanocomposite EnablesIntestinal Delivery of Resveratrol for Effective Ulcerative ColitisTherapy

Abstract Resveratrol (Res) is a plant polyphenol with diverse bioactivities, yet its application is limited by poor water solubility and low bioavailability. Therefore, an edible nanodelivery system composed of a zein/citric acid complex was developed to encapsulate Res@ZC-NPs sh...

A Hybrid Vision Transformer and EfficientNet-B3 Framework for Facial Expression Recognition

Facial expression recognition technology is vital for security, verification, and personalization, but it faces challenges due to variations in scale, illumination, occlusion, and facial expressions. This paper presents a hybrid architecture that combines Vision Transformers (ViT...

The Photolysis of Diethyl, 3, 6-Dimethyl-2, 7-Octadienedioate

The title compound (4) was prepared and photolyzed to give 1, 4 Dimethyl-endo-5, exo-6-dicarboethoxy [2, 1, 1] bicyclohexane (5) exclusively. Compound 5 was characterized by its spectra and the spectra of some of its derivativer.