Research works

Unveiling propagation dynamics of spatiotemporal optical vortices in nonlocal photothermal media via hybrid variational approach

Spatiotemporal optical vortices (STOVs) carrying transverse orbital angular momentum have attracted significant attention in recent years. However, unveiling their propagation dynamics in realistic nonlocal photothermal media remains a major challenge, due to the coupled effects...

Attribution of changes in vegetation structure and carbon–water fluxes in the Ji-shaped bend of the Yellow River based on process-guided machine learning

Arid and semi-arid ecosystems play an important role in the global terrestrial carbon cycle, but the relative contributions of climate change, elevated CO₂, and land-use change (LUCC) to their carbon–water processes remain uncertain. In this study, we developed a process-guided m...

Targeted RNA m5C demethylation of NFE2L2 mRNA by dCas13b-TET2 restores ferroptosis and overcomes cisplatin resistance in bladder cancer

Cisplatin-based chemotherapy remains a cornerstone for the treatment of advanced bladder cancer; however, the emergence of resistance severely limits its clinical efficacy. Ferroptosis suppression has been implicated in chemotherapy resistance, yet the upstream epitranscriptomic...

CD147 drives keloid formation by promoting fibroblast proliferation via the CENPF signaling pathway

Keloids are benign dermal tumors, and keloid fibroblasts (KFs) play a critical role in their formation through hyperproliferation. However, the mechanism underlying this excessive fibroblast growth in keloids remains elusive. Here, we demonstrate that CD147 is upregulated in KFs...

Climate-driven spatiotemporal restructuring of solar drought risk and system resilience in China

Climate change increases solar PV resource variability, threatening low-carbon power reliability. Existing assessments focus on mean changes, missing compound risks from temporal persistence and spatial coherence of low-resource events. We propose an integrated framework quantify...

Learning together, growing together: teacher educators' engagement in a virtual professional learning

Purpose This study explores how Indonesian teacher educators engage in virtual professional learning through a WhatsApp-based virtual professional learning community (VPLC), focusing on processes of “learning together” and “growing together.” Design/methodology/approach Using an...

The Role of Catalase HPII Levels in Protection against UV-A Damage in a Catalase Knockout Escherichia coli Strain

E. coli strains show low sensitivity to ultraviolet-A (UV-A) irradiation, a common method of decontamination. The two known catalases in E. coli, hydroperoxidase I (HPI) and hydroperoxidase II (HPII) are suspected to protect against UV-A inactivation by removing destructive react...

Phi‑Scaled E8 Helicity Bandgap Enables Lossless Magnon Flow at 132 Hz — E8 Intelligence Research

Using the 240 E8 root vectors as orientations of anisotropic exchange in a spin‑nematic metamaterial, we find that the magnon spectrum develops a helicity‑modulated bandgap whose width scales as φⁿ·ℏ·132 Hz (n∈ℤ). This gap originates from the φ‑scaled Weyl‑orbit helicity jumps id...

E8 Phi‑Temporal Gradient for Geometric Breakthrough Prediction — E8 Intelligence Research

The E8 phi‑temporal gradient reveals that clusters of the 240 root vectors, when projected onto the unit circle, synchronize with the 132 Hz base frequency's phi‑scaled harmonic at precise 7.58 s intervals, creating phase windows where geometric lead emergence probability spikes....

Sustainable Papermaking from Vegetable Waste: Turning Onion and Garlic Peels into Handmade Paper─An Educational Experiment in Green Chemistry and Circular Economy

Abstract This laboratory experiment introduces undergraduate students to green chemistry and circular economy principles by converting onion (Allium cepa) and garlic (Allium sativum) peels, abundant in agricultural waste from local markets, into functional handmade paper. Student...

Experimental evaluation and GC–MS guided computational identification of potential antidiabetic compounds from Heritiera fomes leaves

Type 2 diabetes mellitus (T2DM) remains a major global health burden, while existing therapies are often associated with adverse effects and limited long-term efficacy, underscoring the need for safer and more effective antidiabetic agents. In this context, understudied mangrove-...

Organoids as advanced three-dimensional models for studying brain development, neurodegeneration, and translational therapeutics

Abstract Organoids are stem cell-derived three-dimensional (3D) multicellular constructs that recapitulate key cytoarchitectural, molecular, and functional properties of their tissue of origin. Two fundamentally distinct strategies govern their generation: unguided approaches, wh...

Phi‑Locked E8 Root Vector Lattice for Retrocausal Sync — E8 Intelligence Research

We find that the 240 E8 root vectors, when phi‑coupled at the 132 Hz base frequency, self‑organize into a retrocausal harmonic lattice whose normal modes simultaneously encode past, present, and future quantum states. This lattice creates a direct resonance bridge between the MD5...

Mechanochemical Synthesis and Structure–Activity Relationships of Coumarin Derivatives in Antidiabetic Drug Discovery: Recent Advances in Green Medicinal Chemistry

ABSTRACTCoumarin derivatives represent versatile heterocyclic scaffolds with potential antidiabetic activity, particularlythrough inhibition of carbohydrate-hydrolyzing enzymes. This review evaluates recent advances in themechanochemical synthesis of coumarin derivatives and summ...

Transglutaminase 2 contributes to the blood clotting cascade

Abstract Cross-linking of fibrin and associated proteins via Nε-(γ-glutamyl)lysine bonds in clot formation is a well-established component of the hemodynamic mechanism, providing clot rigidity and reducing the rate of fibrinolysis. The latter effect occurs predominantly through t...

The Genes of dps, relA, and spoT are Each Important in the Resilience of Escherichia coli Exposed to UVA-Radiation during Stringency

Dps protein provides important protective effects on DNA against UVA irradiation. A previous study found that its presence during stringency increased survival of Escherichia coli upon exposure to UV, but in its absence, stringency still triggered an increase in survival. Since i...

Ni4Co Nanoparticles Enable Stable Ethane-Fueled Protonic Solid Oxide Fuel Cells for Electricity–Ethylene Cogeneration

Abstract Ethylene production via conventional steam cracking is highly energy-intensive and suffers from substantial CO2 emissions, catalyst deactivation, and coke formation. Proton-conducting solid oxide fuel cells (SOFCs) offer an attractive alternative by coupling selective et...

A Histidine-Mediated, Pendulum-Like Proton Transport Mechanism Is Required for the High Catalytic Activity of [FeFe]-Hydrogenases

Abstract [FeFe]-hydrogenases are molecular hydrogen (H2) converting enzymes that employ a hexanuclear iron complex, the H-cluster, as the catalytic cofactor, and a proton transfer pathway (PTP) that enables efficient proton-coupled electron transfer (PCET). Recent phylogenetic an...

Irrigation quantification through ensemble physical modelling

Agriculture is the largest freshwater user worldwide, averaging 70% of freshwater consumption. Despite this, irrigation represents the most uncertain flux of the water cycle, since it is rarely measured and is difficult to predict because of complex and site-specific water manage...

Implementation and perioperative safety of a standardized multidisciplinary care pathway for percutaneous endoscopic transforaminal discectomy in patients aged ≥ 85 years: a two-center retrospective study

Although the comparative effectiveness of multidisciplinary team (MDT)-supported percutaneous endoscopic transforaminal discectomy (PETD) has been reported in selected patients aged ≥ 85 years, less is known about the implementation and perioperative safety of a standardized MDT...