Research works

Incremental effects for continuous exposures

Causal inference problems often involve continuous treatments, such as dose, duration, or frequency. However, identifying and estimating standard dose-response estimands requires that everyone has some chance of receiving any level of the exposure (i.e., positivity). To avoid thi...

Allelic gene conversion softens selective sweeps

The prominence of positive selection, in which beneficial mutations are favored by natural selection and rapidly increase in frequency, is a subject of intense debate. Positive selection can result in selective sweeps, in which the haplotype(s) bearing the adaptive allele sweep t...

Uniqueness of certain cylindrical tangent cones

Abstract We show that the cylindrical tangent cone $C\times \mathbf{R}$ C × R for an area-minimizing hypersurface is unique, where $C$ C is the Simons cone $C_{S}= C(S^{3}\times S^{3})$ C S = C ( S 3 × S 3 ) . Previously Simon proved a uniqueness result for cylindrical tangent co...

Childcare in Transition: Evidence That Patterns of Childcare Differ by Degree of Market Integration in Northwestern Tanzania

Highlights This study uses novel data on multiple childcare types from both kin and nonkin in two culturally similar communities with varying market integration. It tests the hypothesis that market integration is associated with reduced kin support. Who provides support and the t...

The perils of omitting omissions when modeling evidence accumulation

Response deadlines are commonly imposed in decision-making research to incentivize speedy decisions and sustained attention. This procedure frequently leads to a proportion of trials in which no response is made, and these omissions are often simply removed from the data during a...

Inverse scattering in biological samples via beam propagation

Multiple scattering limits optical imaging in thick biological samples by scrambling sample-specific information. Physics-based inverse-scattering methods aim to computationally recover this information, often using non-convex optimization to reconstruct the scatter-corrected sam...

Microtubule regulation in cancer cells

Introduction The notion of microtubule (MT) dynamics relates to the changes in the length of MT polymers in living cells. They are governed by a stochastic process related to the rates and chances of adding or removing tubulin dimers at the ends of MT polymers, termed dynamic ins...

Selecting the number of components in PCA via random signflips

Principal component analysis (PCA) is a foundational tool in modern data analysis, and a crucial step in PCA is selecting the number of components to keep. However, classical selection methods (e.g., scree plots, parallel analysis, etc.) lack statistical guarantees in the increas...

Integrating planetary boundaries into energy system optimisation models for absolute environmental sustainability assessment: a methodological framework

Abstract Transforming energy systems to address climate change must avoid shifting burdens to other planetary boundaries. Yet most energy models still focus primarily on greenhouse gas reduction, often neglecting broader life-cycle impacts on critical Earth-system processes. This...

Pulsations in Binary Star Systems

High-precision and long-duration light curves from space telescopes have revolutionized the fields of asteroseismology and binary star systems. In particular, the number of pulsating systems in eclipsing binaries has drastically increased thanks to space-based observations coveri...

A pathological phosphorylation pattern enhances tau cooperativity on microtubules and facilitates tau filament assembly

Abstract Phosphorylation of the microtubule-associated protein tau plays important roles in both normal physiology and disease. While tau phosphorylation levels are similarly elevated in processes such as fetal development and hibernation and in pathological states like Alzheimer...

First record of Ambulyx japonica Rothschild, 1894 from Russia (Lepidoptera: Sphingidae)

Ambulyx japonica Rothschild, 1894 is reported from Russia for the first time. A single male specimen was collected in Kajmanovka village, Primorsky Krai. Therefore, the Sphingidae fauna of Russia currently comprises 69 species belonging to 34 genera.

First record of Ambulyx japonica Rothschild, 1894 from Russia (Lepidoptera: Sphingidae)

Ambulyx japonica Rothschild, 1894 is reported from Russia for the first time. A single male specimen was collected in Kajmanovka village, Primorsky Krai. Therefore, the Sphingidae fauna of Russia currently comprises 69 species belonging to 34 genera.

Using the simple telegraph model to decipher transcriptional burst regulation across genome-wide data.

). Their interdependent dysregulation accelerated HCM. This study establishes the simple telegraph model as a scalable framework linking transcriptional burst dynamics to cell fate and pathology.

A host-adapted commensal fungus from pet store mice drives type 2 immunity and cross-kingdom protection.

serves as an exemplary commensal mycobiota model, revealing distinct mechanisms for host tolerance and immune modulation.

Language-enhanced generative modeling for amyloid PET synthesis from MRI and blood biomarkers.

Assessment of amyloid pathology in Alzheimer's disease (AD) often relies on amyloid-beta positron emission tomography (Aβ-PET), but its clinical use is limited by cost and accessibility. We developed a language-enhanced generative framework to synthesize Aβ-PET images from T1-wei...

Photoreceptor-specific scene statistics reveal melanopic structure in natural environments.

), revealing photoreceptor-resolved regularities in natural melanopic input.

Expanding CIRdb, a comprehensive catalog of whole-exome sequencing data of Canary Islanders.

) gene, which is associated with body mass index, cardiovascular health, and metabolic and respiratory traits. Taken together, our findings show that CIRdb presents a valuable resource of exome-wide genetic variation in a population at the edge of Southwestern European genetic di...

Generalisation between motor and declarative memory sequences: A conceptual replication of Mosha & Robertson (2016).

= 125) completed a word list and motor sequence task in counterbalanced order with either a shared or distinct sequence structure. In contrast to Mosha and Robertson (2016), we found that a shared ordinal structure between the declarative and motor sequence tasks did not facilita...

Epidural Analgesia in Labor: A Nationwide Evaluation of Utilization in Germany.

BACKGROUND: Lumbar epidural anesthesia (LEA) is considered the gold standard for the treatment of pain during vaginal delivery. Despite procedural advances and high maternal satisfaction in surveys, the extent of LEA utilization in Germany and its trend over time remain unclear....