Research works

LPR-1-Mediated targeted intranasal delivery of lentinan-loaded polymeric nanocarriers for GBM therapy via modulation of apoptotic signalling

Aim To develop and evaluate a lactoferrin (Lf)-functionalized polyethylene glycol (PEG)-grafted chitosan (CS) nanocarriers (NCs) for low-density lipoprotein receptor-related protein-1 (LRP1)-mediated intranasal delivery of lentinan (LNT) to enhance brain targeting and anti-gliobl...

Multimodal profiling of HER2/neu-specific TCR-T cells reveals clonotype-dependent activation programs underlying differential cytotoxic efficacy

Abstract Adoptive T cell therapy targeting tumor-associated antigens offers a promising avenue for cancer immunotherapy, yet the mechanisms underlying functional heterogeneity among T cell receptors recognizing the same antigen remain poorly understood. Here, we comprehensively p...

The World Hammered Flat: Crowd Psychology, Conceptual Compression, and the Political Life of Simplified Meaning

Modern societies circulate vast quantities of information while depending on selection, representation, and compression to make complex realities communicable and actionable. Scientific findings are condensed into headlines; religious traditions are represented through identity m...

Tracking an Archetype: The Child Motif in Dreams and its Transformation in the Process of Psychotherapy

Abstract This study examines the occurrence of the child motif in dream series from psychoanalytic therapies in 38 cases using the grounded theory method. According to C. G. Jung's analytical psychology, archetypal symbols with universal forms emerge during the transformation pro...

More Than Fluid: AI-Derived Pleural Effusion Volume as a Marker of Cardiovascular Congestion in Transcatheter Aortic Valve Implantation

Background/Objectives: Pleural effusions are frequently encountered on pre-procedural computed tomography (CT) scans in patients undergoing transcatheter aortic valve implantation (TAVI). While often regarded as a marker of congestion and advanced cardiovascular disease, their cl...

High‐Detectivity InGaAs/GaAsP Superlattice PIN Photodetector with a Thin Absorber on GaAs substrate for 1100 nm Applications

ABSTRACT III‐V materials exhibit superior optoelectronic properties compared to conventional semiconductors, making them ideal for short‐wavelength infrared (SWIR) photodetectors. These devices are in demand for applications such as telecommunications, LiDAR, and biomedical engin...

Heat, Health and Holidays: Reported Heat Related Adjustments to Australian Tourist Behaviour

ABSTRACT Extreme heat is one of the fastest growing threats to human health, already causing tens of thousands of deaths annually and projected to affect hundreds of millions more people under continued warming. Australians are highly mobile and live in one of the most heat‐expos...

Liquid–liquid phase separation in a minimal explicit-solvent lattice model mimicking protein solutions

Biomolecular condensates play an essential role in cellular processes, and recent studies have focused on understanding their assembly and rational design principles. In this work, we have employed an explicit-solvent minimal statistical mechanical model based on the lattice-gas...

The impact of work-family policies on employee performance in the tourism industry

Purpose This study aims to explore the influence of work-family policies (WFP) existence and accessibility on employee performance within the tourism industry, emphasizing the mediating roles of specific WFP measures and the moderating impact of demanding work. Design/methodology...

Facility 190 DPR Form

State of California Department of Parks and Recreation primary record for Building 190 at Edwards AFB.

A Design-Technology Co-Optimization Framework Based on Process-Parameter Sensitivity Analysis

This paper proposes a design-technology co-optimization (DTCO) framework applicable to advanced technology nodes, which accelerates the process optimization exploration for such nodes. Developing automatic parameter extraction algorithms tailored for the BSIM-CMG model, along wit...

Surface Topography Improvement of Micro-Milled Inconel 718 Slots Through Abrasive Deburring: Comparison Between Polishing and Sanding

Burr formation remains a major challenge in micro milling due to reduced tool dimensions and size-effect phenomena, particularly when machining difficult-to-cut materials such as Inconel 718. This study compares the effectiveness of two abrasive deburring processes, polishing and...

Postbiotic mechanisms of long-term fermented soybean foods in host immunometabolic regulation: a critical appraisal of evidence, contradictions, and precision nutrition perspectives

Traditionally made long-term fermented soybean (LTFS) foods, including doenjang, miso, ganjang, and douchi, are produced through months to years of fermentation under high-salinity conditions (12-20% NaCl), generating convergent postbiotic profiles comprising free amino acids, is...

Can Artificial Intelligence Possess Meaning Without the Pressure to Survive? A Relational Account of Meaning, Grounding, Normativity, and the Limits of Large Language Models

Meaning is routinely conflated with information, representation, linguistic competence, or behavioral success. This Perspective develops a relational account in which meaning is the directional causal value that a difference acquires relative to a system's organization, goals, an...

The Effect of Repeated Bilateral Deep Parasternal Intercostal Plane Catheter Boluses on Analgesia After Cardiac Surgery: A Randomized Controlled Trial

BACKGROUND: Median sternotomy for cardiac surgery is associated with significant postoperative pain. We evaluated whether repeated ropivacaine boluses via bilateral deep parasternal intercostal plane (DPIP) catheters improve analgesia after cardiac surgery. METHODS: In this rando...

Technology-enhanced learning in nursing education: a systematic review

Abstract Background Technology-enhanced learning (TEL), including artificial intelligence (AI), virtual reality (VR), high-fidelity simulation (HFS), and gamification, is increasingly used in nursing education to address limitations in clinical training and support the developmen...

Subchronic Cannabidiol (CBD) Treatment During the Silent Period Fails to Prevent Increased Seizure Susceptibility Following Lithium-Pilocarpine-Induced Status Epilepticus

Introduction. In recent years, cannabidiol (CBD) has been used as an adjunct therapy to anti-seizure medications for the control of seizures in patients with drug-resistant epilepsy. In addition to its anticonvulsant effect, CBD also has well-defined anti-inflammatory properties....

A Review on Janus Nanoparticles: Duality Leading to Prospective Multipotent Applications

Janus nanoparticles (JNPs), named after the bi-faced Roman God has emerged as a hot topic in the present era of nanoscience because of their chemical, structural and physical uniqueness. These particles stand out in the crowd as they are composed of two or more faces with contras...

Multi-objective mixed-integer stochastic programming for housing unit allocation: an integrated framework with application to Saudi Arabian residential development

Purpose Housing unit optimization literature exhibits two critical gaps that limit practical applicability under contemporary policy requirements. First, single-objective profit maximization provides no mechanism to quantify trade-offs between commercial returns and housing affor...

SIMULTANEOUS ESTIMATION OF CLIDINIUM BROMIDE AND CHLORDIAZEPOXIDE IN COMBINED DOSAGE FORM BY RP-HPLC

AbstractAnalytical chemistry is moreover engrossed on enhancements in experimental design, chemo - metricsand the making of novel measurement tools to offer improved chemical information. Analyticalchemistry has applications in forensics, bio - analysis, environmental analysis an...