Research works

Mechanisms underpinning the progression of nondysplastic Barrett's oesophagus to cancer

Barrett's oesophagus is the metaplastic precursor to oesophageal adenocarcinoma; it is initiated by exposure of the squamous oesophageal epithelium to acid reflux. Wound repair mechanisms lead to the migration of columnar cells into the denuded lower oesophageal niche. These colu...

Multimodal BERT exploration of uncertain project resilience evolution via textual and log data joint modeling

To address the need for dynamic project resilience evaluation under uncertainty and the difficulty of jointly modeling risk texts and execution logs, this study proposes a Multimodal-BERT joint modeling framework for analyzing project resilience evolution. The framework combines...

Guest-DrivenFlexibility in a Hydrogen-Bonded OrganicFramework for NH3 Capture

Abstract Ammonia (NH3) capture and low-energy release remain a critical challenge in adsorptive separation. Herein, we report a guest-driven flexible hydrogen-bonded organic framework (HOF), designated FDU-HOF-7, constructed from 1,3,5-benzenetricarboxylic acid. The as-synthesize...

Wheat Flour Substitution with Sacha Inchi Tea Leaf Powder: Effects on Physicochemical Properties, Starch Digestibility, and Sensory Attributes of Cookies

Sacha inchi (Plukenetia volubilis L.) leaves are an underutilized by-product of an expanding oilseed crop, yet their use as a food ingredient remains limited. This study evaluated sacha inchi tea leaf powder (STLP) as a partial replacement for wheat flour in cookies at 0%, 2.5%,...

TargetingArginine Metabolism via ArcR: BlestriareneB Suppresses Staphylococcus aureus BiofilmFormation and Cellular ATP Production

Abstract Blestriarene B (BB), a biphenanthrene compound isolated from the medicinal plant Bletilla striata, possesses antibacterial properties against Staphylococcus aureus; however, its molecular target and underlying mechanisms remain unclear. Arginine metabolism plays a pivota...

Multifactorial ecological framework for intestinal-type gastric cancer

Gastric cancer (GC) remains one of the leading causes of cancer-related mortality worldwide, with projections indicating increasing incidence and marked geographic variability across populations. Although multiple hypotheses have been proposed to explain this heterogeneity, inclu...

A Dynamic Epistemic Logic with Lying and Theory of Mind Limitations

Abstract Theory of mind (ToM) is the ability to attribute and reason about unobservable mental states of others, such as knowledge, beliefs, and intentions. ToM is needed in social interactions, negotiations, cooperation, and deception, but there is a limit to the recursive depth...

Early Clinical Safety and Performance of a Novel Paclitaxel-Coated Balloon Catheter in Superficial Femoral and Popliteal Arteries

Abstract This study aimed to assess the clinical safety and performance of the novel paclitaxel-coated balloon (PCB) catheter in the superficial femoral artery (SFA) and/or the popliteal artery (PA) in patients with de novo or non-stented restenotic lesions during routine clinica...

Step-brothers in arms, SAGA and ATAC co-activator complexes, use different strategies

Abstract Transcriptional co-activator complexes play essential roles in regulating gene transcription by integrating signals from transcription factors and chromatin. Among these, the SAGA (Spt-Ada-Gcn5 acetyltransferase) and ATAC (Ada Two-A Containing) complexes represent relate...

Game-Based Learning Activities (GBLA): Enhancing the Mathematics – Numbers and Algebra Instruction for Key Stage 2 Learners

Abstract. Mathematics remains one of the most challenging learning areas in elementary education, particularly in the domains of Numbers and Algebra, where many learners experience persistent difficulties in mastering fundamental concepts and computational skills. These learning...

The Aspirational Scale Effect: A Theory of How Larger Goals Can Raise the Probability of Reaching Lower Thresholds

This paper introduces the Aspirational Scale Effect (ASE), a conceptual theory proposing that setting a substantially larger aspirational target can, under certain conditions, increase the probability of reaching a lower success threshold. The theory argues that larger goals can...

The Transmission Mechanism of Monetary Expansion to Corporate Distress: A Case Study of Carvana Co. Under the Post-Pandemic Inflationary Regime

This academic research paper constructs a mathematically rigorous, structurally integrated micro-macro econometric framework designed to isolate and quantify the exact transmission mechanisms through which systemic macroeconomic monetary shocks propagate into corporate capital st...

Liposomal Nanocarriers for Tuberculosis Therapy: Design, Challenges, and Clinical Translation

AbstractTuberculosis (TB) remains one of the leading infectious causes of death globally, withMycobacterium tuberculosis infecting an estimated 10.6 million people in 2022 and claiming 1.3million lives. The emergence of multidrug-resistant (MDR-TB) and extensively drug-resistant(...

Superficial Temporal Artery Access for Angiography in a Patient With Leriche Syndrome, Subclavian Artery Occlusions, Multiple Acute Arterial Thromboses, and Heart Failure

Despite significant progress in revascularization techniques, the vascular approach itself can still be a challenge in complex polyvascular disease. In this case report, we describe the feasibility of a potentially underutilized alternative vascular approach in a patient with mul...

High-contiguity genome assembly and annotation of the citrus-derived Diaporthe sojae strain J-7

Diaporthe is a taxonomically complex genus that includes pathogens, endophytes, and saprobes associated with diverse plant hosts. Diaporthe sojae is historically linked to soybean diseases, but individual isolates may occur in other host contexts; strain J-7 was obtained from cit...

Ultrafast Photochemical Reaction Dynamics of a Cyclic (Alkyl)(Amino)Carbene-Carbon Disulfide Dimer Probed by Femtosecond Infrared Spectroscopy

The ultrafast photochemical reaction dynamics of a cyclic(alkyl)(amino)carbene–carbon disulfide (CAAC–CS2) dimer containing two adjacent S–S bonds were investigated using femtosecond time-resolved infrared spectroscopy in combination with multireference electronic structure calcu...

Bioinspired Hierarchical Cellulose/MXene Fibers for Integrated Capture and Ultrasensitive Detection of Microplastics in Complex Biological Matrices

ABSTRACT The long‐standing disconnection between enrichment and identification processes fundamentally limits the reliable tracing of microplastics (MPs) in complex aqueous and biological environments. Inspired by the synergistic structure–function design of bee leg villi, we rep...

Catfish Transgenesis and Gene Editing: Overview, Recent Advances, and Future Perspectives

Transgenesis and gene editing offer a promising approach for more efficient and sustainable aquaculture by generating high-performance fish to enhance global food security. This article provides a comprehensive review of the history, current status, and future perspectives of emp...

Height-Based Stratification in Greenhouse Harvesting Robotics: A Review from Ground-Level to High-Wire Crops

Labor shortages and the push for higher greenhouse efficiency have accelerated interest in automated harvesting. However, the development of a universal harvesting robot has been constrained by large variations in crop architecture, especially plant height. In this review, a heig...

Nonabelian composition factors of finite groups whose maximal subgroups are complemented: A solution to Kourovka Problem 18.68

Status: This preprint claims a complete CFSG-conditional solution to Kourovka Problem 18.68, but it has not yet been externally refereed or established by publication. It proves that the possible nonabelian composition factors of a finite group whose maximal subgroups are complem...