Research works

Metabolic reprogramming of macrophage-specific transketolase orchestrates angiogenesis in diabetic wounds

Diabetic wound healing is profoundly impaired by macrophage metabolic dysfunction, which compromises angiogenesis. Here, we show a macrophage transketolase (TKT) as a crucial metabolic checkpoint governing vascular regeneration in diabetes. We demonstrate that loss of TKT in macr...

BaeR, EvgA and CpxR Differentially Regulate the Expression of acrD in Escherichia coli K-12 but Increased acrD Transcription Alone Does Not Demonstrate a Substantial Increase in Adaptive Resistance Against Kanamycin

Escherichia coli K-12 possesses the transmembrane AcrAD-TolC multidrug efflux complex. This pump is involved in the efflux of a variety of antibiotics, as well as amphipathic compounds. Studies suggest that the pretreatment of E. coli K-12 with kanamycin resulted in adaptive resi...

Ethnotaxonomy and phenotypic evidence for a zone of high common bean (Phaseolus vulgaris L.) diversity in northeastern Amazonian Peru

Abstract The common bean ( Phaseolus vulgaris L.) is a key crop in the Americas, yet its diversity in the Peruvian Amazon Basin remains poorly documented. We examined geographic and ethnographic patterns in vernacular naming and phenotypic diversity of common beans across three b...

Prime order and permutation properties of eight EKG-type sequences

We give short complete proofs of several conjectures and observations recorded in the OEIS for greedy sequences of EKG type. A381873 (EKG on the numbers with at most two distinct prime factors) is a permutation of those numbers, and its primes appear in increasing order. A251622...

Response: Risk factors associated with antenatal mental disorder in pregnant women with gestational diabetes: A systematic review

Data sharing is not applicable to this article as no new data were created or analyzed in this study.

Economic Growth and Multidimensional Environmental Performance in Developing Countries: An EKC Perspective on Energy Efficiency and Clean Energy Transition

Economic growth in developing countries remains closely tied to fossil fuel dependence, generating persistent tension between development and environmental sustainability. This conceptual paper revisits the Environmental Kuznets Curve (EKC) framework to conceptualises how economi...

Transcription of katG is Enhanced in Escherichia coli exposed to UV-A and might enhance cell survival.

The solar water disinfection (SODIS) method relies on UV-A irradiation from natural sunlight for bactericidal treatment of drinking water. This study investigated the indirect effects of UV-A irradiation on Escherichia coli growth, death and gene expression. It has been previousl...

Paraclostridium bifermentans S1-GT1 spores: a novel approach for oncolytic therapy

The core regions of solid tumors are characterized by hypoxia, which limits the efficacy of conventional therapies. Anaerobic bacterialspores represent a promising therapeutic strategy because they can germinate and proliferate in hypoxic regions. This study evaluatedthe antitumo...

Current perspectives in the pharmacological management of cutaneous and mucosal leishmaniasis

Introduction Leishmaniasis encompass a heterogeneous spectrum of neglected tropical diseases, with clinical course and treatment outcomes strongly influenced by Leishmania species and geographic setting. Despite recent advances, their pharmacological management remains challengin...

Systemic capillary leak syndrome during online hemodiafiltration leading to cardiac arrest

Abstract Background Systemic capillary leak syndrome (SCLS) is a rare disorder characterized by transient plasma extravasation from the intravascular space into surrounding tissues, resulting in hemoconcentration, hypoalbuminemia, and hypotension. Although SCLS most commonly affe...

Prevalence and risk factors for impaired tissue integrity in long-term care settings: A multicenter study

This multicenter, cross-sectional study aimed to determine the prevalence and characteristics of tissue integrity impairments including pressure injuries (PIs), incontinence-associated dermatitis, skin tears, and medical device–related PIs among older adults residing in long-term...

Connecting the Dots: The Cellular Energy Addendum

Connecting the Dots: The Cellular Energy Addendum Subtitle: Why the Brain's Power Supply Flatlines from Chronic Stress and Keeps Children Trapped in a Trauma Loop Author: Lauren Brown, Independent Parent ResearcherRelation: A Separate Companion Piece to Connecting the Dots on Sch...

Logging and thinning generate distinct post-management vegetation conditions that shape bird communities

This study examined contrasting post-management vegetation conditions and bird-community responses following logging and thinning in managed forests. Bird surveys were conducted at 34 sites across three regions in South Korea from August 2022 to May 2025. Sites represented four m...

E8 Fermionic Chirality Locking via 132Hz Heptagonal Phase Coherence — E8 Intelligence Research

The 132Hz base frequency combined with the heptagonal field's 7-fold symmetry partition of E8 roots into 30-element classes establishes a chirality-locking mechanism for fermion generations: each of the three Standard Model generations corresponds to a Z₃ sub-cycle within the 7-f...

ASSESSING PERIODICITY IN TIME SERIES DATA USING PERSISTENT HOMOLOGY

Topological Data Analysis (TDA), a novel method rooted in algebraic topology, offers a powerful framework for quantifying the structure of high-dimensional datasets. This study focuses on Persistent Homology (PH), a key TDA method, to elucidate the underlying shape and structure...

Artificial Consciousness - An Experimental Framework for AI Safety

Mikael Hedman is a former Swedish Armed Forces officer and management consultant whose work now centers on consciousness and human development under the name Swedish Buddha. This proposal brings his exploration of consciousness into dialogue with questions of artificial intellige...

Perceived personalization of social media ads and online compulsive purchase

The increasing integration of social networking, online shopping, and personalized advertising has created a digital environment in which consumers are continuously exposed to consumption-related cues. This study examines the effects of heavy social networking, financial social c...

A Colletotrichum orbiculare-based fungal model recapitulates conserved cellular defects of Niemann–Pick type C disease and enables therapeutic evaluation

Abstract Niemann–Pick type C disease is a fatal lysosomal storage disorder caused by mutations in NPC1 or NPC2 , leading to lipid accumulation and progressive neurodegeneration. Current mammalian models recapitulate major pathological features but are limited by long disease cour...

Nanotechnology Strategies to Mitigate Antimicrobial Resistance in Fish Aquaculture Systems

Abstract Aquaculture plays an increasingly important role in global food production, but intensive freshwater fish aquaculture still faces major challenges related to infectious diseases and the use of antimicrobials. Antimicrobials are commonly administered orally through medica...

Simulation of behavior of combustion reaction in non-uniform size particle HMX explosives under drop hammer impact based on 3D-DEM

In practice, macroscopic explosives consist of explosive particles of varying sizes, which are referred to as non-uniform size particle explosives in this paper. It is meaningful to study the ignition and combustion of non-uniform size particle explosives for their safety predict...