Research works

Mathematical modeling for a primitive form of habituation in an amoeba

Abstract Learning abilities, once thought to be unique to higher animals, have been reported to exist in their primitive form in single-celled organisms. This has triggered a growing interest in carefully examining the nature and mechanisms of the primitive versions of learning a...

Characterizing intra- and intertumor heterogeneity in ovarian high-grade serous carcinoma subtypes using single-cell and spatial transcriptomics

Ovarian high-grade serous carcinoma (HGSC) is an aggressive ovarian cancer with a heterogeneous tumor microenvironment (TME). Advances in single-cell RNA sequencing (scRNA-seq) and spatially-resolved transcriptomics have enabled the study of complex TME. This study explores conne...

Unraveling the effects of fracture density and intensity on reservoir connectivity and flow behavior

<title>Abstract</title> Understanding the factors that influence fluid flow in fractured reservoirs is crucial for optimizing production and enhancing reservoir management. While extensive studies have focused on network characterization, the direct influence of density and inten...

Effectiveness of sexual health interventions in reducing risky sexual behaviors among people living with HIV: a network meta-analysis and systematic review

Abstract Objectives To assess and rank the effectiveness of different sexual health interventions designed to address risky sexual behaviors in PLWH. Methods We systematically searched studies published between Jan. 2010 and Dec. 2024. Randomized controlled trails (RCTs) were inc...

Unpacking the state-private nexus in China’s AI development path

The Chinese AI regulatory model has been described as state-driven, where the Chinese government seeks technological supremacy by deploying AI to entrench power through surveillance, control, and cooptation of public and private sectors. It is portrayed as a comprehensive, top-do...

Hysteresis and irreversibility in permafrost physical response to increase and decrease of CO 2 emissions

Abstract. Boreal permafrost over the Northern Hemisphere high latitudes, defined as areas where the ground temperature is below 0 °C for two or more years, stores more than twice as much carbon as the atmosphere. Therefore, thawing of the permafrost, a tipping element, due to glo...

Laser Interstitial Thermal Therapy for Brain Tumors: A Prospective Multicenter Analysis of Patients From the LAANTERN Study

Background: Laser interstitial thermal therapy is a surgical tool used to ablate brain tumors, radiation necrosis, and epileptic foci. Data from the completed LAANTERN prospective multicenter registry (NCT02392078), containing tumor patients enrolled in the study across 25 US cen...

Nutrient–Microbiota Co-Regulation of Protein Conversion in Black Soldier Fly Larvae: The Role of Alkali-Soluble Protein and Gut Microbial Communities

Insect protein farming provides sustainable advantages in land efficiency, emission reduction, and bioconversion. A major challenge is optimizing nutrient composition to achieve cost-effective protein production. This study investigates the co-regulatory mechanism between alkali-...

Building emission reduction feasibility assessment considering uncertainty

The building sector accounts for 37% of global carbon emissions, which is commonly recognized as a significant contributor to carbon emissions. The emission reduction related to the building sector has received widespread attention. Scientific calculation and assessment of buildi...

Tiny Droplets, Large Insights: Studying Peptide Aggregationwith Droplet-Based Microfluidics Hyphenated with Ion Mobility MassSpectrometry

Abstract Peptide and protein aggregation are hallmarks of numerous neurodegenerative diseases. However, the structural characterization of oligomeric intermediates remains challenging due to their low abundance, heterogenic nature, and complexity of coinciding and transient react...

Virtual coronary artery bypass grafting

<title>Abstract</title> Coronary artery bypass grafting (CABG) offers superior long-term survival over percutaneous coronary intervention (PCI) or medical therapy in patients with complex coronary artery disease (CAD). This prospective proof-of-concept study aims to develop and v...

Stage-Specific Gene Expression Profiles in Multiple Sclerosis Cortical Lesions Identified via Spatial Transcriptomics

<title>Abstract</title> Background and Objectives Multiple sclerosis (MS) is a chronic inflammatory disease characterized by demyelinating lesions in the central nervous system. While animal models have provided valuable insights into lesion development, human-based studies—parti...

Structural and electrochemical investigation of Fe-doped sheet-like ZnCo₂O₄ as battery-type electrode for high-performance hybrid supercapacitors

Multi-transition metal spinel oxides with nanostructures have become interesting options for improving the electrochemical performance of next-generation supercapacitors. By synthesizing pure ZCO, 5% Fe-doped ZCO, and 10% Fe-doped ZCO, the structural and electrochemical effects o...

Stochastic modeling of labor supply and discouraged worker behavior

Discouraged workers are those who have given up searching for work because of the (perceived) low chances of obtaining it. In this paper we develop a stochastic structural econometric framework for analyzing discouraged worker behavior based on the theory of job search and the no...

Self-reflection resilience-recovery activity promotion training for emergency medical service clinicians: A randomized controlled pilot trial of a novel digital intervention.

Objectives: The emergency medical service profession needs resilience interventions that address clinicians’ mental health risk. This study performed a randomized controlled pilot trial examining 1) feasibility, acceptability, and adoptability of a novel digital intervention: Sel...

Optimal Policy Analysis for Monotonic (PO)MDPs and an Application to Fishery Management

<title>Abstract</title> We study the monotonicity properties of optimal policies for a class of fully/partially observable Markov Decision Processes (MDPs) motivated by renewable natural resource management. We first introduce a new class of deterministic monotonic MDPs with cont...

Chinese students’ L2 classroom engagement in college: Perceived teacher support, value beliefs and self-monitoring

<title>Abstract</title> Based on an integrated framework of the Self-Determination Theory and the Expectancy-Value Theory, this study investigated the link between students’ perceived teacher support and their L2 classroom engagement via two mediators: students’ value beliefs of...

Derivation of human post-mitotic cardiomyocytes from tetraploid iPSCs

Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes (iPS-CMs) have great potential in regenerative medicine. However, iPS-CMs are immature and resemble fetal cardiomyocytes, restricting their application. Fetal cardiomyocytes in the human heart are diploid and proli...

Development of a PEGylated parylene nanopocket membrane for the capture and release of lipid vesicles

Membranes are commonly used for the separation and purification of a variety of biological species. In this study, we developed a nanopocket membrane that can capture nanoparticles and extracellular vesicles in tangential flow filtration by pulling the species of interest into a...

Algebraic characterization of equivalence between oracle-based iterative algorithms

Abstract When are two algorithms the same? How can we be sure a recently proposed algorithm is novel, and not a minor variation on an existing method? In this paper, we present a framework for reasoning about equivalence between a broad class of iterative algorithms, with a focus...