Research works
The research papers we track — the newest first. Works with a plain-language summary link to it.
76240 work(s)
- Health & MedicineOpen access
Frailty, sarcopenia, and malnutrition are common in older adults; however, simple biomarkers reflecting both inflammatory and nutritional status remain limited. We aimed to evaluate the relationship between the uric acid-to-prealbumin ratio (UPR) and frailty, muscle strength, and...
- Engineering & TechnologyOpen access
Green synthesized zero valent iron nanoparticles (nZVI) are promoted as environmentally benign alternatives to chemically synthesized ones. Simulation models are used to predict nZVI transport and transformation during environmental remediation. The objective of this study was to...
- AI & ComputingOpen access
Dynamic treatment regimes (DTRs) are statistical methods that use patient-specific information to estimate an optimal sequence of treatments, with the end goal of maximizing a desired outcome of interest. DTRs have many useful applications to chronic disease management when patie...
- Health & MedicineOpen access
Hypoxemia in chronic obstructive pulmonary disease (COPD) typically arises from ventilation-perfusion (V/Q) mismatch. However, refractory hypoxemia should raise concern for alternative mechanisms, such as intracardiac shunting. This report describes a rare presentation where a ca...
- Health & Medicine
Clinical Utility of a Type 1 Diabetes Genetic Risk Score Measured as Part of MODY Genetic Testing
<p dir="ltr">Objective</p><p dir="ltr">To evaluate the clinical utility of incorporating a type 1 diabetes genetic risk score (T1DGRS) into monogenic diabetes gene panel testing for individuals referred with suspected maturity-onset diabetes of the young (MODY)...
- Health & MedicineOpen access
To evaluate the effects of ultrasound-guided right stellate ganglion block (SGB) combined with propofol-based general anesthesia on perioperative hemodynamics, postoperative pain, recovery, and inflammatory stress responses in women undergoing laparoscopic myomectomy. In this sin...
- Society & EconomicsOpen access
BACKGROUND: Despite growing research interest on the influences of migration and regions of residence on human behaviors, studies on the influences of migration and region of residence on women empowerment especially in sub-Saharan Africa are lacking. Thus, this study investigate...
- Health & MedicineOpen access
Cell-based Therapies in Acute Lymphoblastic Leukemia Treatment: Current Advancements and Limitations
Acute lymphoblastic leukemia (ALL) is a hematologic malignancy characterized by clonal expansion of immature lymphoid precursors in the bone marrow and extramedullary sites. Although frontline chemotherapy induces remission in most patients, relapse, treatment resistance, and cum...
- Health & MedicineOpen access
Road traffic injuries are a major cause of morbidity and mortality among older adults, frequently leading to prolonged hospitalization, functional decline, and loss of independence. Large-scale disasters, such as earthquakes, may act as important modifiers of mobility patterns an...
- BiologyOpen access
Alpha-synuclein (SNCA) overexpression is implicated in Parkinson's disease (PD) pathogenesis, making SNCA downregulation a promising therapeutic strategy. We developed a SNCA -targeted transcriptional repression therapy using an all-in-one lentiviral vector (LV) carrying deactiva...
- Society & EconomicsOpen access
From international experience to global mindset: The contingent role of organizational context
Global mindset is widely recognized as essential for navigating cultural diversity and strategic complexity in multinational enterprises (MNEs). While prior research has identified individual factors influencing its development, less is known about how individual and organization...
- Health & MedicineOpen access
Left-sided obstructive lesions (LSOLs), represented by coarctation of the aorta (CoA), cause persistent vascular pathology and pressure overload that can lead to pathological cardiac remodeling. However, the epigenetic changes associated with local vascular abnormalities and vent...
- Materials & EnergyOpen access
This study developed a new method based on homogenizer-assisted dispersive liquid-liquid microextraction (HA-DLLME) followed by ion mobility spectrometry (IMS) for determining fluconazole in different samples. A homogenizer was used to disperse the extraction solvent, which has t...
- Health & MedicineOpen access
Total thyroidectomy (TT) is the standard surgical approach for hereditary medullary thyroid cancer (hMTC). However, it is not rare in clinical practice for patients with hMTC to initially undergo hemithyroidectomy (HT) because the hereditary nature of the disease is not recognize...
- Health & MedicineOpen access
Postoperative pancreatic fistula (POPF) is the most common and clinically significant complication following distal pancreatectomy (DP). Despite numerous randomized trials evaluating stump closure and reinforcement techniques, the optimal strategy remains uncertain. We conducted...
- Health & MedicineOpen access
This multicohort, single-center, phase II trial explored the efficacy and safety of a biomarker-driven total neoadjuvant therapy (TNT) regimen in high-risk locally advanced rectal cancer (LARC) patients. The regimen included induction chemotherapy (4 cycles of mFOLFOX6) with targ...
- Health & MedicineOpen access
Background: Lupus anticoagulant hypoprothrombinemia syndrome (LAHPS) is a rare, acquired coagulopathy characterized by the presence of lupus anticoagulant and deficiency of factor II, causing paradoxical bleeding despite prothrombotic antibodies. LAHPS may cause falsely low INR v...
- BiologyOpen access
Rice paddies are major sources of methane (CH 4 ) and nitrous oxide (N 2 O), yet co-managing water and nitrogen (N) to limit both gases remains challenging because emissions arise from non-linear interactions among multiple drivers. We combined a two-year field experiment in subt...
- Health & MedicineOpen access
Virological surveillance of chikungunya in Burkina Faso in 2024
Chikungunya is an emerging arbovirus disease transmitted by mosquitoes of the genus Aedes , mainly Aedes aegypti and Aedes albopictus . Since it was first identified in Tanzania in 1952, the virus has caused numerous epidemics around the world. Despite arbovirus surveillance sinc...
- Health & MedicineOpen access
Cellulite is a prevalent cosmetic concern among postpubertal women, and the efficacy of conventional topical therapies remains limited. Green coffee bean extract (GCBE) exhibits antioxidant and lipolytic activities relevant to cellulite management; however, its topical performanc...