Research works

Transport of cytotoxic cyanine dyes coupled to siRNA into hematopoietic cancer cells with CD20-, CD22- or CD33-targeting ELART nanocarriers

Abstract The efficient and safe transfection of hematopoietic cells is a major hurdle that limits efficacy of therapeutic approaches like RNA-interference. We therefore used our modular EL ectrostatic A ntibody si R NA T argeted therapy platform (ELART) to develop nanocarriers de...

Time-dependent divergence in infection risks among patients with multiple sclerosis treated with fumarates versus anti-CD20 monoclonal antibodies

Background: People with multiple sclerosis (pwMS) treated with anti-CD20 monoclonal antibodies have an elevated infection risk, yet long-term comparative data with oral fumarates are limited. Objective: To compare infection incidence, healthcare resource utilization, and relapse...

Projectile penetration into corundum rubble ultra‐high performance concrete: Test and meso‐scale simulation

Abstract Aiming to systematically explore the penetration resistance of corundum rubble ultra‐high performance concrete (CR‐UHPC) with varying oblique and attack angles of projectile, firstly, the laboratory‐based penetration tests (175 m/s) of a 105 mm caliber projectile on CR‐U...

Recent Increaseof Greenhouse Gas Emissions from Cryosphere-InfluencedReservoirs under Climate Change

Abstract Global warming leads to cryosphere degradation, transferring large amounts of terrestrial carbon and nitrogen to reservoirs, which may accelerate the release of greenhouse gases (GHGs) to the atmosphere. However, the spatial dynamics and decadal trends of GHG emissions f...

A Hybrid Transfer Learning Approach for Ambient PM2.5 Exposure Modeling in LMIC Contexts: A Case Study from Lima, Peru

Abstract Exposure to fine particulate matter (PM2.5) contributes to millions of premature deaths annually worldwide. While epidemiological studies increasingly rely on geospatial technologies, such as satellite remote sensing, low-cost sensors, and chemical transport models, to q...

EuroMillions Breakthrough Mining — 1925 Sources, 14652 Leads Extracted — E8 Intelligence Research

Mined 1925 lottery+quantum breakthroughs. Extracted 14652 leads across 13 categories. 12579 high-value leads found. Categories: {"CORRIDOR": 1222, "FORMULA": 1062, "GEOMETRIC": 758, "FORWARD_ATTEMPT": 1294, "QUANTUM": 1504, "TIMING": 222, "CELESTIAL": 1146, "GEMATRIA": 1230, "CON...

Thermal regulation of phenological development in karonda (Carissa carandas L.) based on an extended BBCH scale

This study provides the first integrated phenological and thermal time framework for karonda ( Carissa carandas L.) using the extended BBCH scale. Karonda is an underutilized evergreen fruit crop valued for its adaptability to marginal environments; however, standardized informat...

A PGSA approach to interactive pricing optimization: converting consumer costs into marketing value

Purpose This study reconceptualizes interactive pricing as a reciprocal and value co-creation process that sets personalized optimal prices to drive purchases and profit margins. We introduce Predictive Global Sensitivity Analysis (PGSA) as a method for real-time interactive pric...

Multi-Criteria Technological and Cradle-to-Gate Sustainability Assessment of CEM II/A-S and CEM II/B-V Cements for Heavy Precast Concrete Production

The transition to lower-clinker binders in heavy precast concrete is constrained by the need to combine rapid production cycles, high early-age strength, self-compacting performance, durability and measurable environmental benefits. The scientific gap addressed in this study is t...

Embodied Intelligence-Driven Active Perception and Detection Strategy Learning for Display Defects in Electric Metering Devices

Electric metering display inspection is a critical task in power equipment maintenance, yet practical field images often suffer from reflection, blur, occlusion, low illumination, and subtle segment-level defects. Existing passive inspection methods usually rely on fixed-view ima...

Positivity of the k=1 Toeplitz Minors of the Riemann ξ-Coefficients

We prove strict positivity of the complete (k=1) family of consecutive Toeplitz minors associated with the Taylor coefficients of the Riemann (\xi)-function: D_{r,1} > 0 for every r >= 1. The proof rewrites (D_{r,1}) as a coefficient of the reciprocal generating function a_0 / G(...

Unimodal vs Multimodal Learning: A Systematic Evaluation of Fusion Strategies and Model Design for Molecular Property Prediction and Uncertainty Quantification

Abstract Accurate prediction of molecular properties is fundamental to environmental chemistry, yet remains challenging when experimental data are limited. Multimodal fusion provides a promising strategy for integrating complementary molecular representations; however, the relati...

Husserl must wait: The primacy of phenomenological practice

In this article, I critically examine the assumption that phenomenological practices must be understood exclusively in terms of applied philosophy. There is, I argue, a benefit starting in the practice itself when exploring its character. Here, I elaborate on several practices wi...

EuroMillions Breakthrough Mining — 1953 Sources, 14923 Leads Extracted — E8 Intelligence Research

Mined 1953 lottery+quantum breakthroughs. Extracted 14923 leads across 13 categories. 12836 high-value leads found. Categories: {"CORRIDOR": 1245, "FORMULA": 1085, "GEOMETRIC": 764, "FORWARD_ATTEMPT": 1317, "QUANTUM": 1531, "TIMING": 223, "CELESTIAL": 1170, "GEMATRIA": 1252, "CON...

AI Applied to Formulation Design, Process Optimization, and Quality Control in 3D Printed Drug Products: Protocol for a Scoping Review

Background 3D printing is an advanced, computer-aided design (CAD)–guided, layer-by-layer manufacturing technology with strong potential for producing patient-specific drug products. Integrating AI with pharmaceutical 3D printing can accelerate formulation development, improve pr...

The Longitudinal Changes of Cervical Sagittal Alignment in a Non-surgical Cohort: A 12-Year Longitudinal Study

Study Design A retrospective longitudinal observational cohort study. Objective This study aimed to quantitatively evaluate the natural progression of cervical sagittal alignment parameters in non-surgical patients over a mean 12-year follow-up period, with a specific focus on ag...

High-Quality Complete Genome Assembly of Bacillus velezensis BV2007 and Genomic Insights Into Its Potential for Biocontrol of Apple Valsa Canker

The previous studies in our laboratory have shown that Bacillus velezensis strain BV2007 exhibits a significant biocontrol effect against apple tree canker. In this study, the complete genomic sequence and annotation information of the strain were obtained by using PacBio Revio p...

Examining Practice and Payment Gaps in Otolaryngology: Evidence from US Medicare Data

Abstract Objective To assess longitudinal differences in Medicare reimbursement, billing patterns, and service composition among US otolaryngologists. Study Design Retrospective cohort study. Setting Centers for Medicare & Medicaid Services (CMS) Medicare fee‐for‐service database...

Quantum Probability Framework for Human Decision-Making Under Uncertainty — E8 Intelligence Research

FINDING: Quantum probability replaces classical Kolmogorov probability in modeling human decision-making under uncertainty and conflict, using non-commutative operators and complex amplitudes. | MATH: Quantum probability framework: \( P(A) = |\langle \psi | M_A | \psi \rangle|^2...

A Physics-Informed Multi-Scale Diffusion Model Framework for Physical Field Imputation from Randomly Missing Data

Abstract Non-intrusive optical measurement techniques are widely used to obtain high-resolution pressure, temperature, and velocity fields, but they often suffer from random data loss caused by geometric obstruction, surface reflection, or illumination non-uniformity. Conventiona...