Research works

Bounded Gaps Between Primes: Zhang's 70 Million Bound Reduced to 246 — E8 Intelligence Research

FINDING: Bounded gaps between primes proven via sieve methods and modular arithmetic clustering, revealing hidden structure in prime distribution. | MATH: Zhang's bound: gaps between consecutive primes are infinitely often less than 70 million (later reduced to 246 via Polymath8)...

A Library in the Universe of Possibilities: Tracing Quantum and Chaos in Matt Haig’s The Midnight Library

This study embraces an interdisciplinary approach to examine Matt Haig’s novel The Midnight Library through an analytical framework by blending the superposition principle of the quantum physics with the concept of unpredictability in chaos theory. The novel depicts a peripheral...

Effects of Dynamic Neck Sensorimotor Biofeedback Training in Individuals With Mechanical Neck Pain: A Pilot Randomized Controlled Trial

Mechanical neck pain (MNP) is commonly accompanied by pain-related functional limitations, sensorimotor disturbances, and fear of movement, which together may contribute to persistent disability. This preliminary randomized controlled trial study investigated the short-term effec...

Comprehensive multi-omics landscape exploration and functional characterization of TACSTD2 throughout pan-cancer

Tumor-associated calcium signal transducer 2 ( TACSTD2 ) is widely investigated in cancer research. Its overexpression across multiple cancers is linked to elevated tumor aggressiveness, metastasis, and poor prognosis, making it a potential biomarker for diagnosis, prognosis, and...

KEY GMP AND GCP REQUIREMENTS FOR GENERIC DRUG REGULATIONS IN BRICS, MIST, AND ICH COUNTRIES: A COMPARATIVE REVIEW

Plant-derived medicines are licensed under regulatory categories that sit between traditional herbal preparations and fully synthetic new chemical entities, yet the data requirements attached to their market authorisation differ markedly across jurisdictions, and those difference...

The Next Evolution: How Scientists Are Building "Living Machines" From Scratch

Imagine a world where robots aren't made of steel or plastic, but from actual biological cells. No metal wires, no microchips, just pure living tissue programmed like software. Welcome to 2026, where the line between biology and technology has officially vanished. Scientists are...

A systematic review of the effects of vanadium exposure on the health of human populations

BACKGROUND: Vanadium is a metal naturally occurring in various ecosystems. Both natural and anthropogenic sources contribute to high concentrations in the air, soil, and water. Several experimental and epidemiological studies have linked this exposure to multiple adverse health e...

Community Environment, Parenting Practices, Social Support, and Children’s Quality of Life in Shanghai, China: A Multi-Scalar and Gendered Analysis

Abstract This study investigates the relationships between community environment, parenting practices, social support, and children’s quality of life in Shanghai. Grounded in a “4D” framework (Density, Design, Diversity, and Destination), we employed a multi-scalar geospatial app...

Quantum Teleportation Confirms Energy Transfer, Upholds Light-Speed Limit — E8 Intelligence Research

FINDING: Quantum teleportation experiments confirm transfer of quantum information and, in new results, quantum energy; no classical information transfer faster than light. | MATH: Key equation: teleportation fidelity \( F = \langle \psi | \rho_{\text{out}} | \psi \rangle \), typ...

Associations of IL-2, IL-6 and IL-10 Gene Polymorphisms with Biochemical Parameters and Calcineurin Inhibitor Dosing in Kidney Transplant Recipients

Background/Objectives: Kidney graft dysfunction remains a major challenge limiting long-term transplant survival despite advances in immunosuppressive therapy. Cytokine signaling pathways have been implicated in the regulation of alloimmune responses and chronic inflammation, but...

Ultra-Short Hollow-Core Anti-Resonant Fiber Polarization Filter Covering C+L Band Based on SPR Effect

This paper proposes an ultra-short hollow-core anti-resonant fiber (HC-ARF) polarization filter covering the C+L communication band based on the surface plasmon resonance (SPR) effect. The structure consists of six composite tubes, each formed by nesting an elliptical cladding tu...

Hydrodynamic characteristics of an ILCA6 sailing dinghy in calm water and head waves

Abstract The ILCA6 (formerly Laser Radial) sailing dinghy frequently encounters wave conditions during training and competition, where wave-induced resistance and ship motions can significantly influence sailing performance. However, systematic investigations of the hydrodynamic...

Advancing durable and sustainable asphalt binder: Hybrid modification using recycled polypropylene and crumb rubber

This paper introduces a comprehensive framework for hybrid crumb rubber-recycled polypropylene binders, investigating the effects of formulation, mixing techniques, and ageing paths using rheological characterisation. Two shear-mixing protocols were used to create hybrid binders...

Late recurrence after radical nephrectomy for renal cell carcinoma in a patient with horseshoe kidney: a case report

Introduction: Horseshoe kidney (HSK) is the most common renal fusion malformation. Renal cell carcinoma (RCC) is the most prevalent malignancy reported in this anomaly. Case presentation: We present the case of a 61-year-old man with multiple recurrences of RCC in the context of...

RKMS / COR External Handoff Package — Release Candidate 0.1.1

RKMS / COR RC 0.1.1 is a recoverable technical handoff of a typed relational architecture, executable semantic checker (COR-IR), relational-search/candidate-generation bridge, relational navigation loop, provenance machinery, frozen tests, preserved failures, reproduction scripts...

Intersectionality and Its Influence on PrEP Uptake and Adherence Among MSM: A Scoping Review

Oral pre-exposure prophylaxis (PrEP) is an effective human immunodeficiency virus (HIV) biomedical intervention. However, men who have sex with men (MSM) continue to experience disproportionately high HIV prevalence due to intersecting marginalised identities and systemic inequit...

Dynamic Uncertainty Learning with Noisy Correspondence for Text-based Person Retrieval

Text-Based Person Retrieval (TBPR) aims to locate a person in an image database based on a natural language description. While effective in theory, TBPR faces substantial challenges in real-world scenarios due to noisy correspondences —misaligned or weakly related image-text pair...

Genetic Architecture of Synaptic Failure in Dementia with Lewy Bodies: From α-Synuclein Proteoforms to GBA1-Mediated Plasticity Deficits

Dementia with Lewy bodies (DLB) is increasingly conceptualised not merely as a disorder of neuronal death but as a primary synaptopathy in which the functional collapse of synaptic transmission and plasticity precedes, and predicts, neurodegeneration and clinical decline. Two gen...

Agentic AI for Data Engineering: A Systematic Review of Autonomous Pipeline Construction, Optimization, and Governance

Data engineering is increasingly cited as a proving ground for agentic AI, with surveys reporting daily AI tooluse among 82% of data professionals — yet most of that use remains tactical rather than autonomous, and only a small fraction of teams describe their data modeling pract...

Vaccinations during pregnancy in Germany between 2004 and 2022: a claims data analysis

Abstract Data on vaccinations during pregnancy are lacking in Germany. We aimed to assess the proportion of pregnancies with any vaccination over a 19-year period. Using health claims covering approximately 20% of the German population, we included pregnancies beginning between 2...